Development Level

Tchem 31 | 1,890
Tbio 25 | 10,625
Tclin 15 | 602
Tdark 2 | 7,003

Collection

Eligible Ion Channel Proteins 7 | 117

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating amylase ... 2 | 24
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal eye size 1 | 11
abnormal facial morphology 1 | 9
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal radius morphology 1 | 8
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
absent mammary gland 1 | 1
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased skeletal muscle mass 1 | 1
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
edema 1 | 11
enlarged heart 1 | 111
hemorrhage 1 | 12
hyperactivity 1 | 108
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased neutrophil cell numb... 1 | 15
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
limb grasping 1 | 35
male infertility 1 | 62
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
respiratory system phenotype 1 | 2
short tibia 1 | 82
small epididymis 1 | 3
small heart 1 | 8
small kidney 1 | 10
small ovary 1 | 1
small spleen 1 | 11
small uterus 1 | 1
thin skin 1 | 1

Disease

glioblastoma 36 | 5,572
medulloblastoma, large-cell 36 | 6,234
ovarian cancer 33 | 8,484
psoriasis 33 | 6,685
osteosarcoma 31 | 7,933
atypical teratoid / rhabdoid tumor 27 | 4,369
lung cancer 26 | 4,466
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
primitive neuroectodermal tumor 24 | 3,031
lung carcinoma 23 | 2,844
pilocytic astrocytoma 23 | 3,086
adult high grade glioma 22 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
ependymoma 20 | 2,514
invasive ductal carcinoma 20 | 2,950
Carcinoma 19 | 2,147
interstitial cystitis 18 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
lung adenocarcinoma 18 | 2,713
ulcerative colitis 16 | 2,087
Breast cancer 15 | 3,094
Cancer 15 | 2,346
Pick disease 15 | 1,893
medulloblastoma 15 | 1,524
oligodendroglioma 15 | 2,849
pediatric high grade glioma 15 | 2,712
malignant mesothelioma 14 | 3,162
subependymal giant cell astrocytoma 14 | 2,287
Hypertension 13 | 287
colon cancer 12 | 1,475
non-small cell lung cancer 12 | 2,798
posterior fossa group A ependymoma 11 | 1,511
tuberculosis 10 | 1,557
astrocytic glioma 9 | 2,241
cystic fibrosis 9 | 1,665
diabetes mellitus 9 | 1,663
ductal carcinoma in situ 9 | 1,745
group 3 medulloblastoma 9 | 2,254
pancreatic cancer 9 | 2,300
primary pancreatic ductal adenocarcinoma 9 | 1,271
group 4 medulloblastoma 8 | 1,875
pituitary cancer 8 | 1,972
primary Sjogren syndrome 8 | 789
Asthma 7 | 349
adrenocortical carcinoma 7 | 1,427
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
cutaneous lupus erythematosus 7 | 1,056
juvenile dermatomyositis 7 | 1,189
Alzheimer's disease 6 | 644
Hypertensive disease 6 | 193
Malignant hyperthermia 6 | 25
Multiple Sclerosis 6 | 498
aldosterone-producing adenoma 6 | 664
dermatomyositis 6 | 933
nasopharyngeal carcinoma 6 | 1,056
Atherosclerosis 5 | 275
Bipolar Disorder 5 | 266
Epilepsy 5 | 346
Kidney disease 5 | 396
Neurodegenerative disease 5 | 383
Obesity 5 | 616
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
fibroadenoma 5 | 557
sarcoidosis 5 | 358
Amyotrophic Lateral Sclerosis 4 | 431
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Autistic Disorder 4 | 320
Dementia 4 | 129
Heart disease 4 | 279
Hypersensitivity reaction type II disease 4 | 235
Hypertensive disorder 4 | 58
Hypervitaminosis D 4 | 8
Intellectual disability 4 | 573
Kidney cancer 4 | 118
Lung disease 4 | 132
Myopathy 4 | 128
Peripheral Neuropathy 4 | 303
Rickets 4 | 42
Schizophrenia 4 | 501
acute quadriplegic myopathy 4 | 1,157
atypical teratoid/rhabdoid tumor 4 | 1,095
non-small cell lung carcinoma 4 | 413
periodontitis 4 | 269
progressive supranuclear palsy 4 | 674
Allergic hypersensitivity disease 3 | 123
Down syndrome 3 | 548
Endometriosis 3 | 535
Eosinophilia 3 | 65
Migraine 3 | 79
Myocardial Ischemia 3 | 169
Polycystic Ovary Syndrome 3 | 332
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic rhinosinusitis 3 | 512
nephrosclerosis 3 | 329
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064

Tissue

Blood and immune system 71 | 17,995
Cardiovascular System 71 | 17,958
Endocrine System 71 | 18,512
Female tissues 71 | 18,647
Digestive Tract 70 | 18,473
Nervous System 70 | 18,561
Urinary Tract 70 | 18,444
Liver and Pancreas 69 | 18,136
Male tissues 69 | 17,969
Respiratory system 69 | 17,484
Skin and soft tissues 69 | 18,115

Target Family

Ion Channel 30 | 341
Non-IDG 20 | 11,971
GPCR 6 | 406
Transporter 6 | 473
Enzyme 5 | 4,146
Kinase 5 | 634
Nuclear Receptor 1 | 48

GO Process

calcium ion transport 73 | 73
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tchem Ion Channel -0.48027 2.02 53
Sodium leak channel non-selective protein NALCN Tbio Ion Channel -1.58010 42.7 36
Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 Tchem Ion Channel -2.38460 284.0 184
Translationally-controlled tumor protein TPT1 Tbio Non-IDG -2.70459 550.0 375
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.65191 464.3 66
Neuronal acetylcholine receptor subunit alpha-7 CHRFAM7A Tchem Ion Channel -1.90534 84.1 211