Development Level

Tchem 26 | 1,598
Tbio 17 | 11,445
Tclin 9 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 6 | 99
RFA-RM-18-021 6 | 328

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased circulating alkaline... 3 | 46
increased startle reflex 3 | 112
decreased prepulse inhibition 2 | 82
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
limb grasping 2 | 41
abnormal eye morphology 1 | 68
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 49 | 11,493
glioblastoma 28 | 5,792
Kidney cancer 26 | 2,613
medulloblastoma, large-cell 25 | 6,241
osteosarcoma 25 | 7,950
atypical teratoid / rhabdoid tumor 23 | 5,112
ovarian cancer 20 | 8,520
group 3 medulloblastoma 19 | 4,104
adult high grade glioma 18 | 3,801
ependymoma 18 | 4,679
primitive neuroectodermal tumor 18 | 3,035
psoriasis 18 | 6,694
Astrocytoma, Pilocytic 15 | 3,081
invasive ductal carcinoma 15 | 2,951
Pick disease 14 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung cancer 13 | 4,740
oligodendroglioma 13 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung carcinoma 12 | 2,843
Breast cancer 11 | 3,578
pituitary cancer 11 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
pancreatic cancer 10 | 2,398
Bipolar Disorder 9 | 666
Hypertension 9 | 396
Melanoma 9 | 711
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
cystic fibrosis 8 | 1,696
malignant mesothelioma 8 | 3,232
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Cancer 7 | 2,499
colon cancer 7 | 1,478
Dentin sensitivity 6 | 14
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Intellectual disability 6 | 1,016
Liver cancer 6 | 604
Neurodegenerative disease 6 | 414
Schizophrenia 6 | 1,160
Skin cancer 6 | 469
ductal carcinoma in situ 6 | 1,745
Neuropathy 5 | 261
Schnyder Corneal Dystrophy 5 | 23
cutaneous lupus erythematosus 5 | 1,057
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
pediatric high grade glioma 5 | 1,064
progressive supranuclear palsy 5 | 676
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Brain Ischemia 4 | 110
Hypertensive disease 4 | 292
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Migraine 4 | 83
Type 2 diabetes mellitus 4 | 272
active Crohn's disease 4 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
non primary Sjogren syndrome sicca 4 | 891
Asthma 3 | 385
Autosomal dominant cerebellar ataxia 3 | 33
Cardiomegaly 3 | 116
Cerebellar Ataxia 3 | 304
Cerebrovascular accident 3 | 63
Dementia 3 | 175
Episodic ataxia 3 | 22
Gangliosidosis 3 | 20
Heart disease 3 | 306
Hyperalgesia 3 | 83
Hypertensive disorder 3 | 56
Inflammation 3 | 120
Mood Disorders 3 | 184
Pain 3 | 103
Pain agnosia 3 | 104
Psychotic Disorders 3 | 151
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Spinocerebellar Ataxias 3 | 34
Status Epilepticus 3 | 98
Vascular disease 3 | 319
active ulcerative colitis 3 | 764
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
head and neck cancer 3 | 271
inflammatory breast cancer 3 | 286
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
sonic hedgehog group medulloblastoma 3 | 467
Adenoma 2 | 167
Atrial Fibrillation 2 | 124
Dermatitis 2 | 157
Peripheral vascular disease 2 | 87
medulloblastoma 2 | 720
substance-related disorder 2 | 162

Tissue

Endocrine System 53 | 18,159
Digestive Tract 51 | 17,369
Nervous System 50 | 16,725
Urinary Tract 50 | 16,678
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Blood and immune system 48 | 16,909
Skin and soft tissues 48 | 17,230
Female tissues 46 | 17,400
Respiratory system 45 | 16,393
Cardiovascular System 39 | 15,192

Target Family

Ion Channel 39 | 344
Transporter 6 | 473
Non-IDG 5 | 12,091
Enzyme 2 | 4,145
GPCR 1 | 408
Kinase 1 | 634

GO Process

calcium ion transmembrane tran... 54 | 54
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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