Development Level

Tbio 152 | 11,651
Tchem 21 | 1,388
Tdark 8 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 9 | 499
abnormal behavior 6 | 298
decreased body weight 5 | 161
embryonic lethality prior to o... 5 | 239
abnormal kidney morphology 4 | 65
abnormal seminal vesicle morph... 4 | 114
decreased circulating alanine ... 4 | 47
decreased circulating glucose ... 4 | 126
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
increased body weight 4 | 25
increased mean corpuscular hem... 4 | 96
abnormal embryo size 3 | 220
decreased blood urea nitrogen ... 3 | 51
decreased circulating insulin ... 3 | 76
edema 3 | 59
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal vibrissa morphology 2 | 25
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased prepulse inhibition 2 | 82
decreased threshold for audito... 2 | 26
decreased vertical activity 2 | 208
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased prepulse inhibition 2 | 32
increased startle reflex 2 | 112
increased vertical activity 2 | 24
limb grasping 2 | 41
polycystic kidney 2 | 15
prenatal lethality 2 | 28
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased startle reflex 1 | 75
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 130 | 11,493
osteosarcoma 96 | 7,950
ovarian cancer 94 | 8,520
atypical teratoid / rhabdoid tumor 88 | 5,112
medulloblastoma, large-cell 86 | 6,241
glioblastoma 84 | 5,792
ependymoma 77 | 4,679
psoriasis 75 | 6,694
lung cancer 60 | 4,740
adult high grade glioma 59 | 3,801
group 3 medulloblastoma 59 | 4,104
Astrocytoma, Pilocytic 56 | 3,081
oligodendroglioma 56 | 2,850
Breast cancer 52 | 3,578
Kidney cancer 52 | 2,613
Cancer 48 | 2,499
malignant mesothelioma 47 | 3,232
Intellectual disability 46 | 1,016
primitive neuroectodermal tumor 45 | 3,035
invasive ductal carcinoma 41 | 2,951
non-small cell lung cancer 41 | 2,890
astrocytic glioma 40 | 2,597
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
pancreatic cancer 35 | 2,398
Epilepsy 33 | 792
lung adenocarcinoma 33 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
pituitary cancer 32 | 1,972
Pick disease 31 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
lung carcinoma 31 | 2,843
tuberculosis 30 | 2,010
Autosomal recessive predisposition 29 | 1,442
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
ductal carcinoma in situ 27 | 1,745
Schizophrenia 26 | 1,160
Seizures 24 | 596
breast carcinoma 24 | 1,638
group 4 medulloblastoma 24 | 1,855
interstitial cystitis 24 | 2,312
astrocytoma 23 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
cystic fibrosis 22 | 1,696
Rheumatoid arthritis 20 | 1,191
Autistic Disorder 19 | 364
Liver cancer 19 | 604
adrenocortical carcinoma 19 | 1,428
Bipolar Disorder 18 | 666
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
acute quadriplegic myopathy 18 | 1,158
colon cancer 18 | 1,478
diabetes mellitus 18 | 1,728
medulloblastoma 18 | 720
Microcephaly 16 | 166
Muscle hypotonia 16 | 571
active ulcerative colitis 16 | 764
Short stature 15 | 531
primary pancreatic ductal adenocarcinoma 15 | 1,109
Alzheimer's disease 14 | 658
Cleft Palate 14 | 271
Small head 14 | 374
juvenile dermatomyositis 14 | 1,187
pediatric high grade glioma 13 | 1,064
spina bifida 13 | 1,074
ulcerative colitis 13 | 1,819
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Melanoma 12 | 711
Strabismus 12 | 270
active Crohn's disease 12 | 922
cutaneous lupus erythematosus 12 | 1,057
Duchenne muscular dystrophy 11 | 601
Multiple myeloma 11 | 1,332
Nystagmus 11 | 317
Prostatic Neoplasms 11 | 495
dermatomyositis 11 | 966
Atopic dermatitis 10 | 952
Cataract 10 | 297
Cryptorchidism 10 | 296
Endometrial cancer 10 | 311
Hypertensive disease 10 | 292
Lissencephaly 10 | 69
Liver Cirrhosis, Experimental 10 | 769
Uranostaphyloschisis 10 | 167
Waldenstrons macroglobulinemia 10 | 765
gastric carcinoma 10 | 807
progressive supranuclear palsy 10 | 676
sonic hedgehog group medulloblastoma 10 | 467
Agenesis of corpus callosum 9 | 83
Congenital hypoplasia of penis 9 | 176
Hydrocephalus 9 | 152
Obesity 9 | 678
acute myeloid leukemia 9 | 783

Tissue

Endocrine System 187 | 18,159
Digestive Tract 180 | 17,369
Female tissues 178 | 17,400
Nervous System 177 | 16,725
Male tissues 176 | 17,142
Skin and soft tissues 176 | 17,230
Liver and Pancreas 172 | 16,750
Urinary Tract 171 | 16,678
Blood and immune system 169 | 16,909
Respiratory system 167 | 16,393
Cardiovascular System 158 | 15,192

Target Family

Non-IDG 91 | 12,091
Enzyme 36 | 4,145
Transcription Factor 28 | 1,400
Kinase 13 | 634
Transporter 10 | 473
Epigenetic 4 | 242
GPCR 3 | 408
Ion Channel 3 | 344

GO Process

brain development 188 | 188
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Cbp/p300-interacting transactivator 1 CITED1 Tbio Non-IDG -1.74130 57.5 210
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.26911 24.4 92
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
CDK5 regulatory subunit-associated protein 1 CDK5RAP1 Tbio Non-IDG -1.30040 19.0 133
Nodal homolog NODAL Tbio Non-IDG -3.00545 981.7 245
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.05503 10.4 159