Development Level

Tbio 142 | 10,625
Tchem 27 | 1,890
Tclin 7 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 7 | 633
decreased lean body mass 6 | 195
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
decreased body weight 5 | 174
embryonic lethality prior to t... 4 | 187
increased body weight 4 | 42
decreased circulating LDL chol... 3 | 37
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
hyperactivity 3 | 108
increased bone mineral content 3 | 92
increased mean corpuscular hem... 3 | 93
increased total body fat amoun... 3 | 57
short tibia 3 | 82
abnormal gait 2 | 51
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
absent vibrissae 2 | 14
corneal opacity 2 | 25
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased grip strength 2 | 123
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
increased vertical activity 2 | 18
limb grasping 2 | 35
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal tail movements 1 | 12
abnormal urination 1 | 2
abnormal vibrissa morphology 1 | 17
abnormal vitreous body morphol... 1 | 7
convulsive seizures 1 | 11
decreased B cell number 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating free fat... 1 | 39
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
enlarged epididymis 1 | 27
enlarged kidney 1 | 7
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
improved glucose tolerance 1 | 56
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
increased thermal nociceptive ... 1 | 9
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
tremors 1 | 34

Disease

osteosarcoma 98 | 7,933
ovarian cancer 92 | 8,492
medulloblastoma, large-cell 85 | 6,234
glioblastoma 77 | 5,572
psoriasis 74 | 6,685
atypical teratoid / rhabdoid tumor 59 | 4,369
lung cancer 57 | 4,473
pilocytic astrocytoma 57 | 3,086
oligodendroglioma 54 | 2,849
Cancer 48 | 2,346
malignant mesothelioma 47 | 3,163
Breast cancer 46 | 3,099
primitive neuroectodermal tumor 44 | 3,031
Carcinoma 43 | 2,147
invasive ductal carcinoma 40 | 2,950
non-small cell lung cancer 40 | 2,798
pediatric high grade glioma 38 | 2,712
subependymal giant cell astrocytoma 38 | 2,287
ependymoma 37 | 2,514
lung adenocarcinoma 35 | 2,714
pituitary cancer 35 | 1,972
adult high grade glioma 34 | 2,148
atypical teratoid/rhabdoid tumor 34 | 1,095
group 4 medulloblastoma 34 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
Intellectual disability 32 | 573
Pick disease 32 | 1,893
astrocytoma 32 | 1,493
lung carcinoma 32 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
medulloblastoma 30 | 1,524
pancreatic cancer 30 | 2,300
astrocytic glioma 29 | 2,241
interstitial cystitis 27 | 2,299
posterior fossa group A ependymoma 27 | 1,511
ductal carcinoma in situ 25 | 1,745
group 3 medulloblastoma 25 | 2,254
breast carcinoma 24 | 1,614
tuberculosis 24 | 1,563
sonic hedgehog group medulloblastoma 23 | 1,482
Rheumatoid Arthritis 22 | 1,171
cystic fibrosis 22 | 1,670
posterior fossa group B ependymoma 21 | 1,530
colon cancer 20 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
Epilepsy 19 | 346
adrenocortical carcinoma 19 | 1,427
ulcerative colitis 19 | 2,087
Autistic Disorder 18 | 320
acute quadriplegic myopathy 18 | 1,157
diabetes mellitus 17 | 1,663
primary pancreatic ductal adenocarcinoma 16 | 1,271
Microcephaly 15 | 149
juvenile dermatomyositis 14 | 1,189
Prostatic Neoplasms 13 | 471
Schizophrenia 13 | 503
cutaneous lupus erythematosus 13 | 1,056
Multiple myeloma 12 | 1,328
active Crohn's disease 12 | 918
spina bifida 12 | 1,064
Alzheimer's disease 11 | 644
active ulcerative colitis 11 | 477
Duchenne muscular dystrophy 10 | 602
gastric carcinoma 10 | 832
progressive supranuclear palsy 10 | 674
Atopic dermatitis 9 | 944
chronic rhinosinusitis 9 | 512
dermatomyositis 9 | 967
non primary Sjogren syndrome sicca 9 | 840
Down syndrome 8 | 548
Mammary Neoplasms 8 | 410
Melanoma 8 | 261
Multiple Sclerosis 8 | 498
Waldenstrons macroglobulinemia 8 | 765
acute myeloid leukemia 8 | 785
aldosterone-producing adenoma 8 | 664
esophageal adenocarcinoma 8 | 737
nasopharyngeal carcinoma 8 | 1,056
Gaucher disease type 1 7 | 171
Holoprosencephaly 7 | 52
Hydrocephalus 7 | 60
Hypertension 7 | 293
Lissencephaly 7 | 61
Polycystic Ovary Syndrome 7 | 335
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
chronic lymphosyte leukemia 7 | 232
gastric cancer 7 | 436
nephrosclerosis 7 | 329
non-small cell lung carcinoma 7 | 413
pancreatic carcinoma 7 | 567
tuberculosis and treatment for 6 months 7 | 686
Adenoma 6 | 165
Cerebrovascular disease 6 | 231
Hydrolethalus syndrome 6 | 128
Kidney disease 6 | 397
Obesity 6 | 616
Stomach Neoplasms 6 | 282
glioblastoma multiforme 6 | 347
hepatocellular carcinoma 6 | 550

Tissue

Endocrine System 183 | 18,512
Digestive Tract 182 | 18,473
Female tissues 182 | 18,647
Male tissues 182 | 17,969
Nervous System 182 | 18,561
Skin and soft tissues 182 | 18,115
Urinary Tract 182 | 18,444
Liver and Pancreas 181 | 18,136
Cardiovascular System 179 | 17,958
Blood and immune system 178 | 17,995
Respiratory system 177 | 17,484

Target Family

Non-IDG 87 | 11,969
Enzyme 35 | 4,146
Transcription Factor 29 | 1,400
Kinase 13 | 634
Transporter 9 | 473
Epigenetic 4 | 242
GPCR 3 | 408
Ion Channel 3 | 341

GO Process

brain development 183 | 183
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.22853 25.3 76
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.18842 137.5 94
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.57734 41.1 65
Protocadherin-18 PCDH18 Tdark Non-IDG -0.52190 3.43 78
Roundabout homolog 2 ROBO2 Tbio Non-IDG -1.86221 68.8 144
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.62322 398.1 207
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tbio Enzyme -1.63886 40.3 110
Solute carrier family 23 member 1 SLC23A1 Tbio Transporter -1.80065 57.1 54
Sodium-coupled neutral amino acid transporter 3 SLC38A3 Tbio Transporter 0.00000 46
Adenylate kinase 4, mitochondrial AK4 Tchem Kinase -1.81907 64.9 250