Development Level

Tbio 118 | 10,625
Tchem 29 | 1,890
Tclin 15 | 602
Tdark 7 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 6 | 260
enlarged heart 4 | 111
abnormal seminal vesicle morph... 3 | 47
embryonic lethality prior to t... 3 | 187
tremors 3 | 34
abnormal heart morphology 2 | 51
abnormal retinal pigmentation 2 | 61
decreased bone mineral content 2 | 157
decreased circulating glycerol... 2 | 19
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
thrombocytopenia 2 | 46
vertebral transformation 2 | 12
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal coat-hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye anterior chamber ... 1 | 3
abnormal eyelid aperture 1 | 3
abnormal femur morphology 1 | 14
abnormal iris pigmentation 1 | 3
abnormal kidney morphology 1 | 30
abnormal liver size 1 | 4
abnormal ovary morphology 1 | 3
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spine curvature 1 | 7
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal vibrissa morphology 1 | 17
absent epididymis 1 | 2
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
fusion of vertebral arches 1 | 7
impaired glucose tolerance 1 | 52
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
mydriasis 1 | 9
oligodactyly 1 | 14
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small superior vagus ganglion 1 | 20
small testis 1 | 37
vertebral fusion 1 | 23

Disease

ovarian cancer 90 | 8,491
osteosarcoma 80 | 7,933
psoriasis 65 | 6,685
lung cancer 62 | 4,473
glioblastoma 60 | 5,572
medulloblastoma, large-cell 57 | 6,234
Cancer 52 | 2,346
pancreatic cancer 49 | 2,300
atypical teratoid / rhabdoid tumor 48 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
non-small cell lung cancer 42 | 2,798
ulcerative colitis 42 | 2,087
lung carcinoma 41 | 2,844
invasive ductal carcinoma 39 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
malignant mesothelioma 38 | 3,163
interstitial cystitis 37 | 2,299
pediatric high grade glioma 37 | 2,712
lung adenocarcinoma 36 | 2,714
Breast cancer 35 | 3,098
pilocytic astrocytoma 35 | 3,086
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
tuberculosis 29 | 1,563
primitive neuroectodermal tumor 27 | 3,031
oligodendroglioma 26 | 2,849
colon cancer 25 | 1,475
ductal carcinoma in situ 25 | 1,745
pituitary cancer 24 | 1,972
primary pancreatic ductal adenocarcinoma 24 | 1,271
cystic fibrosis 23 | 1,670
gastric carcinoma 23 | 832
Cerebrovascular disease 22 | 231
breast carcinoma 22 | 1,614
group 3 medulloblastoma 22 | 2,254
subependymal giant cell astrocytoma 22 | 2,287
posterior fossa group A ependymoma 21 | 1,511
Thrombocytopenia 20 | 105
Thrombophilia 20 | 37
diabetes mellitus 20 | 1,663
ependymoma 20 | 2,514
group 4 medulloblastoma 20 | 1,875
Anemia 19 | 252
Coronary artery disease 19 | 240
astrocytoma 19 | 1,493
juvenile dermatomyositis 19 | 1,189
pancreatic carcinoma 19 | 567
Rheumatoid Arthritis 18 | 1,170
astrocytic glioma 18 | 2,241
cutaneous lupus erythematosus 18 | 1,056
esophageal adenocarcinoma 18 | 737
Atherosclerosis 16 | 275
Carcinoma 16 | 2,147
Pick disease 16 | 1,893
Vascular disease 16 | 281
Venous Thrombosis 16 | 21
aldosterone-producing adenoma 16 | 664
Multiple myeloma 15 | 1,327
Thrombosis 15 | 42
adrenocortical carcinoma 15 | 1,427
adult high grade glioma 15 | 2,148
primary Sjogren syndrome 15 | 788
sonic hedgehog group medulloblastoma 15 | 1,482
active Crohn's disease 14 | 918
Atopic dermatitis 13 | 944
spina bifida 13 | 1,064
Crohn's disease 12 | 304
Disseminated intravascular coagulation 12 | 32
Protein C deficiency 12 | 19
Pulmonary Embolism 12 | 45
acute myeloid leukemia 12 | 785
dermatomyositis 12 | 966
hepatocellular carcinoma 12 | 550
mucosa-associated lymphoid tissue lymphoma 12 | 480
Down syndrome 11 | 548
Duchenne muscular dystrophy 11 | 602
Kidney disease 11 | 397
Liver Cirrhosis 11 | 101
Myocardial Infarction 11 | 126
Venous Thromboembolism 11 | 34
Waldenstrons macroglobulinemia 11 | 764
acute quadriplegic myopathy 11 | 1,157
atypical teratoid/rhabdoid tumor 11 | 1,095
fibroadenoma 11 | 557
nasopharyngeal carcinoma 11 | 1,056
Heart disease 10 | 279
IGA Glomerulonephritis 10 | 454
interstitial lung disease 10 | 292
posterior fossa group B ependymoma 10 | 1,530
Barrett's esophagus 9 | 185
Bernard-Soulier syndrome 9 | 14
Factor VIII deficiency 9 | 10
Hemophilia B 9 | 11
Hepatitis B 9 | 103
Hypertension 9 | 293
Hypertensive disease 9 | 193
Liver disease 9 | 219
Von Willebrand's disease 9 | 19
nephrosclerosis 9 | 329
urothelial carcinoma 9 | 318

Tissue

Nervous System 168 | 18,560
Female tissues 167 | 18,646
Urinary Tract 166 | 18,443
Digestive Tract 165 | 18,472
Skin and soft tissues 163 | 18,114
Blood and immune system 161 | 17,994
Endocrine System 161 | 18,511
Liver and Pancreas 161 | 18,135
Cardiovascular System 159 | 17,957
Respiratory system 159 | 17,483
Male tissues 155 | 17,968

Target Family

Non-IDG 92 | 11,969
Enzyme 32 | 4,146
Transcription Factor 16 | 1,400
Ion Channel 8 | 341
Kinase 8 | 634
Epigenetic 7 | 242
GPCR 5 | 408
Nuclear Receptor 1 | 48

GO Process

blood coagulation 169 | 169
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.94271 807.7 451
Endothelial protein C receptor PROCR Tbio Non-IDG -2.67797 519.6 324
Proteinase-activated receptor 1 F2R Tclin GPCR -2.76897 534.6 399
Vitamin K-dependent gamma-carboxylase GGCX Tclin Enzyme -1.87118 72.8 177
A-kinase anchor protein 10, mitochondrial AKAP10 Tbio Enzyme -1.41278 26.4 193
Zinc finger protein ZFPM1 ZFPM1 Tbio Transcription Factor -2.50335 310.9 77
Hermansky-Pudlak syndrome 6 protein HPS6 Tbio Non-IDG -1.03987 11.5 100
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.26523 184.9 247
Transcription factor GATA-5 GATA5 Tbio Transcription Factor -1.94419 83.7 166