Development Level

Tbio 7 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased mean corpuscular vol... 1 | 79
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 9 | 11,493
ovarian cancer 7 | 8,520
Autosomal recessive predisposition 5 | 1,442
osteosarcoma 5 | 7,950
Cholestasis 4 | 155
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
psoriasis 4 | 6,694
Cancer 3 | 2,499
Failure to gain weight 3 | 365
Fatty liver disease 3 | 103
Hepatomegaly 3 | 285
Intrahepatic cholestasis 3 | 20
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Liver disease 3 | 237
Liver diseases 3 | 87
Obesity 3 | 678
Pediatric failure to thrive 3 | 365
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Anovulation 2 | 21
Atherosclerosis 2 | 291
Cerebellar Ataxia 2 | 304
Cholestasis of pregnancy 2 | 5
Crohn Disease 2 | 45
Depressive disorder 2 | 409
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Epilepsy 2 | 792
Female infertility 2 | 30
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Infertility, Female 2 | 28
Intestinal malabsorption of fat 2 | 5
Kidney disease 2 | 430
Liver Cirrhosis 2 | 181
Muscle Spasticity 2 | 195
Neonatal Jaundice 2 | 30
Neurodegenerative disease 2 | 414
Niemann-Pick disease, type C 2 | 5
Osteoporosis 2 | 363
Phenotypic variability 2 | 150
Polycystic ovary syndrome 2 | 360
Primary hypogonadism 2 | 37
Progressive intrahepatic cholestasis 2 | 4
Prolonged neonatal jaundice 2 | 17
Prostatic Neoplasms 2 | 495
Pruritus 2 | 58
Psychotic Disorders 2 | 151
Schizophrenia 2 | 1,160
Seizures 2 | 596
Splenomegaly 2 | 190
adult high grade glioma 2 | 3,801
alpha-methylacyl-CoA racemase deficiency 2 | 9
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
lung cancer 2 | 4,740
non-small cell lung carcinoma 2 | 317
pancreatic cancer 2 | 2,398
ulcerative colitis 2 | 1,819
Absence of secondary sex characteristics 1 | 22
Acanthosis Nigricans 1 | 27
Alcohol withdrawal syndrome 1 | 20
Brucellosis 1 | 24
Bulimia nervosa 1 | 14
CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 5 1 | 1
Calculus in biliary tract 1 | 2
Cell Transformation, Neoplastic 1 | 97
Cholelithiasis Prevention 1 | 1
Decreased T cell activation 1 | 4
Decreased testosterone in males 1 | 28
Extravasation of Diagnostic and Therapeutic Materials 1 | 6
Gynecomastia 1 | 64
HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 1 | 7
Hyperglycemia 1 | 137
Hyperthyroidism 1 | 53
Hypertriglyceridemia result 1 | 37
Increased bilirubin level (finding) 1 | 18
Intestinal Neoplasms 1 | 12
Lipodystrophy 1 | 40
Metanephric adenoma 1 | 9
Neonatal onset 1 | 21
Neoplastic Cell Transformation 1 | 89
Nephrogenic adenoma 1 | 10
Neurofibrillary degeneration (morphologic abnormality) 1 | 9
Oxyphilic adenoma 1 | 22
Pain 1 | 103
Peroneal nerve paralysis 1 | 11
Polydipsia 1 | 15
Polyuria 1 | 23
Primary cholangitis 1 | 2

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Female tissues 10 | 17,400
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Cardiovascular System 9 | 15,192

Target Family

Enzyme 5 | 4,145
Non-IDG 3 | 12,091
Nuclear Receptor 2 | 48
Transporter 1 | 473

GO Process

bile acid metabolic process 11 | 11
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Phospholipid-transporting ATPase IC ATP8B1 Tbio Transporter -2.47204 273.0 19
Protein ARV1 ARV1 Tbio Non-IDG -1.32971 21.5 68
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.47448 310.5 545
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
3-ketoacyl-CoA thiolase, peroxisomal ACAA1 Tbio Enzyme -2.31883 203.8 197
Nuclear receptor subfamily 5 group A member 2 NR5A2 Tchem Nuclear Receptor -2.49333 323.5 303
Aldo-keto reductase family 1 member C1 AKR1C1 Tchem Enzyme -3.12161 1290.1 172
Bile acid-CoA:amino acid N-acyltransferase BAAT Tbio Enzyme -1.71631 50.3 126