Development Level

Tchem 2 | 1,598
Tclin 2 | 613
Tbio 1 | 11,445

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Carcinoma 5 | 11,493
Cancer 4 | 2,499
osteosarcoma 3 | 7,950
psoriasis 3 | 6,694
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 30
Acute promyelocytic leukemia, FAB M3 2 | 11
Adenocarcinoma of pancreas 2 | 14
Autosomal recessive predisposition 2 | 1,442
Colorectal Neoplasms 2 | 243
Elevated hepatic transaminases 2 | 81
Familial adenomatous polyposis 2 | 32
Hepatic enzyme increased 2 | 81
Hepatomegaly 2 | 285
Kidney cancer 2 | 2,613
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Lymphomatous meningitis 2 | 3
Lynch syndrome 2 | 35
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Sensorineural Hearing Loss (disorder) 2 | 284
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
ovarian cancer 2 | 8,520
ANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME 1 | 1
Abnormal vision 1 | 52
Alpers syndrome 1 | 9
Ataxia, Appendicular 1 | 25
Atrophic condition of skin 1 | 25
Atrophy of testis 1 | 14
Blindness, Cortical 1 | 24
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 1 | 1
Choreoathetoid movements 1 | 32
Choreoathetosis 1 | 32
Congenital hereditary endothelial dystrophy of cornea 1 | 8
Convex nasal ridge 1 | 37
Cortical blindness 1 | 16
Cortical visual impairment 1 | 24
Decreased activity of cytochrome C oxidase in muscle tissue 1 | 10
Decreased distal vibration sense 1 | 4
Dysphonia 1 | 7
EMG: myopathic abnormalities 1 | 22
Ethylmalonic aciduria 1 | 6
Favorable response to levodopa 1 | 6
Gait, Drop Foot 1 | 24
Gastroparesis 1 | 22
High pitched voice 1 | 23
Hyperkyphosis 1 | 111
Hypertriglyceridemia result 1 | 37
Intestinal pseudo-obstruction 1 | 12
Jaw Abnormalities 1 | 5
Kyphosis deformity of spine 1 | 114
Lack of skin elasticity 1 | 10
Lipodystrophy 1 | 40
MANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME 1 | 1
Mandibular hypoplasia-deafness-progeroid syndrome 1 | 1
Micronodular cirrhosis 1 | 12
Mildly increased creatine kinase 1 | 20
Mitochondrial Myopathies 1 | 21
Mitochondrial encephalomyopathy 1 | 15
Mitral Valve Prolapse Syndrome 1 | 39
Mitral regurgitation, mild 1 | 32
Multiple mitochondrial DNA (mtDNA) deletions 1 | 5
Muscle Rigidity 1 | 49
Paraparesis, Spastic 1 | 16
Peripheral sensory axonal neuropathy 1 | 7
Polyneuropathy 1 | 64
Premature Menopause 1 | 31
Primary hypogonadism 1 | 37
Primary physiologic amenorrhea 1 | 55
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1 1 | 5
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 1 | 5
Progressive gait ataxia 1 | 4
Ragged-red fibers 1 | 21
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Relative macrocephaly 1 | 12
Respiratory insufficiency due to muscle weakness 1 | 37
Resting Tremor 1 | 9
Retinitis pigmentosa Y-linked 1 | 9
Seizures, Focal 1 | 14
Sensory ataxic neuropathy 1 | 2
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 1 | 2
Sensory axonal neuropathy 1 | 7
Spider Veins 1 | 17
Split hand-foot malformation 3 1 | 5
Steatohepatitis 1 | 44
Stretched skin 1 | 10
Tonic - clonic seizures 1 | 44
Variation in muscle fiber size 1 | 16
Vestibular dysfunction 1 | 7
Werner syndrome 1 | 29

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

GO Process

base-excision repair, gap-fill... 5 | 5
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
DNA polymerase beta POLB Tchem Enzyme -2.67364 415.2 298
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.22644 169.3 112
DNA polymerase lambda POLL Tbio Enzyme -2.84820 672.6 166