Development Level

Tbio 35 | 10,625
Tchem 25 | 1,890
Tclin 6 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased body weight 3 | 174
decreased bone mineral content 3 | 157
preweaning lethality, complete... 3 | 633
abnormal embryo size 2 | 112
abnormal gait 2 | 51
decreased T cell number 2 | 31
decreased circulating creatini... 2 | 31
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
increased CD4-positive, alpha ... 2 | 15
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
small superior vagus ganglion 2 | 20
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal digit morphology 1 | 13
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal seminal vesicle morph... 1 | 47
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal vibrissa morphology 1 | 17
absent vibrissae 1 | 14
craniofacial phenotype 1 | 9
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating glycerol... 1 | 19
decreased grip strength 1 | 123
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased leukocyte cell numbe... 1 | 37
increased rib number 1 | 41
prenatal lethality prior to he... 1 | 64
tremors 1 | 34

Disease

ovarian cancer 39 | 8,484
Cancer 38 | 2,346
psoriasis 33 | 6,685
lung cancer 30 | 4,466
glioblastoma 29 | 5,572
osteosarcoma 28 | 7,933
medulloblastoma, large-cell 27 | 6,234
lung carcinoma 23 | 2,844
malignant mesothelioma 20 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
cutaneous lupus erythematosus 18 | 1,056
interstitial cystitis 18 | 2,299
pediatric high grade glioma 16 | 2,712
pilocytic astrocytoma 16 | 3,086
Rheumatoid Arthritis 15 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
atypical teratoid / rhabdoid tumor 14 | 4,369
diabetes mellitus 14 | 1,663
Breast cancer 13 | 3,094
pancreatic cancer 13 | 2,300
primitive neuroectodermal tumor 13 | 3,031
tuberculosis 13 | 1,557
Hypersensitivity reaction type II disease 12 | 235
group 3 medulloblastoma 12 | 2,254
non-small cell lung cancer 12 | 2,798
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 2,087
adrenocortical carcinoma 11 | 1,427
cystic fibrosis 11 | 1,665
group 4 medulloblastoma 11 | 1,875
invasive ductal carcinoma 11 | 2,950
pituitary cancer 11 | 1,972
lung adenocarcinoma 10 | 2,713
atypical teratoid/rhabdoid tumor 9 | 1,095
primary Sjogren syndrome 9 | 789
Carcinoma 8 | 2,147
Chronic Lymphocytic Leukemia 8 | 242
Peripheral Neuropathy 8 | 303
Prostatic Neoplasms 8 | 471
active Crohn's disease 8 | 918
breast carcinoma 8 | 1,614
juvenile dermatomyositis 8 | 1,189
posterior fossa group A ependymoma 8 | 1,511
primary pancreatic ductal adenocarcinoma 8 | 1,271
Kidney disease 7 | 396
Multiple myeloma 7 | 1,327
Pick disease 7 | 1,893
astrocytic glioma 7 | 2,241
astrocytoma 7 | 1,493
dermatomyositis 7 | 933
gastric carcinoma 7 | 832
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Arthritis 6 | 248
Asthma 6 | 349
Atherosclerosis 6 | 275
Diabetes Mellitus, Experimental 6 | 106
Duchenne muscular dystrophy 6 | 602
Liver disease 6 | 219
Multiple Sclerosis 6 | 498
Vascular disease 6 | 281
aldosterone-producing adenoma 6 | 664
oligodendroglioma 6 | 2,849
periodontitis 6 | 269
spina bifida 6 | 1,064
Autoimmune Lymphoproliferative Syndrome 5 | 12
Gaucher disease type 3 5 | 76
IGA Glomerulonephritis 5 | 454
Lung Neoplasms 5 | 171
Lung disease 5 | 132
Mammary Neoplasms 5 | 410
Melanoma 5 | 261
Neoplasm Metastasis 5 | 138
Nerve Degeneration 5 | 73
active ulcerative colitis 5 | 477
adult high grade glioma 5 | 2,148
colon cancer 5 | 1,475
ependymoma 5 | 2,514
non-small cell lung carcinoma 5 | 413
pancreatic carcinoma 5 | 567
sonic hedgehog group medulloblastoma 5 | 1,482
Alzheimer's disease 4 | 644
Amyotrophic Lateral Sclerosis 4 | 431
Cardiomyopathies 4 | 90
Crohn's disease 4 | 304
Dermatitis 4 | 107
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Heart disease 4 | 279
Hypertension 4 | 287
Inflammatory bowel disease 4 | 142
Influenza 4 | 142
Neurodegenerative disease 4 | 383
Non-alcoholic Fatty Liver Disease 4 | 40
Obesity 4 | 616
Reperfusion Injury 4 | 84
Stevens-Johnson syndrome 4 | 78
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
gastric cancer 4 | 430

Tissue

Blood and immune system 67 | 17,995
Digestive Tract 66 | 18,473
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Cardiovascular System 65 | 17,958
Female tissues 65 | 18,647
Nervous System 65 | 18,561
Respiratory system 65 | 17,484
Urinary Tract 65 | 18,444
Endocrine System 64 | 18,512
Skin and soft tissues 64 | 18,115

Target Family

Non-IDG 44 | 11,971
Enzyme 9 | 4,146
Kinase 8 | 634
Epigenetic 2 | 242
Ion Channel 2 | 341
GPCR 1 | 406
Nuclear Receptor 1 | 48

GO Process

apoptotic signaling pathway 67 | 67
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.44068 3018.0 1385
Toll-like receptor 3 TLR3 Tchem Non-IDG -3.00214 1147.2 751
Tyrosine-protein kinase BTK BTK Tclin Kinase -2.98909 1061.8 721
Tumor necrosis factor receptor superfamily member 25 TNFRSF25 Tbio Non-IDG -3.25501 1848.4 483
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.69962 490.7 314
Interferon alpha-inducible protein 27, mitochondrial IFI27 Tbio Non-IDG -1.44652 31.7 0
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -0.56310 11.6 230
TIR domain-containing adapter molecule 1 TICAM1 Tbio Non-IDG -1.44846 31.8 191
Tumor necrosis factor ligand superfamily member 6 FASLG Tchem Non-IDG -3.48531 3494.0 818