Development Level

Tbio 347 | 10,625
Tchem 111 | 1,890
Tdark 30 | 7,003
Tclin 18 | 602

Collection

Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, complete... 18 | 633
decreased lean body mass 11 | 195
abnormal behavior 10 | 226
abnormal bone structure 8 | 131
embryonic lethality prior to t... 8 | 187
increased circulating alkaline... 8 | 119
preweaning lethality, incomple... 8 | 260
decreased bone mineral content 7 | 157
decreased bone mineral density 7 | 126
abnormal bone mineralization 6 | 55
decreased grip strength 6 | 123
decreased mean corpuscular vol... 6 | 50
embryonic lethality prior to o... 6 | 148
abnormal embryo size 5 | 112
abnormal lens morphology 5 | 73
abnormal retina morphology 5 | 100
decreased body weight 5 | 174
decreased mean corpuscular hem... 5 | 34
enlarged heart 5 | 111
increased circulating choleste... 5 | 53
increased lean body mass 5 | 107
increased leukocyte cell numbe... 5 | 37
decreased total body fat amoun... 4 | 186
hypoactivity 4 | 89
increased bone mineral density 4 | 52
thrombocytopenia 4 | 46
abnormal coat/hair pigmentatio... 3 | 54
abnormal gait 3 | 51
abnormal retinal pigmentation 3 | 61
decreased circulating glucose ... 3 | 121
decreased circulating iron lev... 3 | 25
decreased fasted circulating g... 3 | 49
decreased lumbar vertebrae num... 3 | 62
hyperactivity 3 | 108
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased circulating glucose ... 3 | 16
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
increased sacral vertebrae num... 3 | 62
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
small superior vagus ganglion 3 | 20
abnormal coping response 2 | 12
abnormal cranium morphology 2 | 32
abnormal heart morphology 2 | 51
abnormal respiratory quotient 2 | 9
abnormal seminal vesicle morph... 2 | 47
abnormal startle reflex 2 | 14
cyanosis 2 | 6
decreased NK T cell number 2 | 28
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating potassiu... 2 | 17
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased granulocyte number 2 | 8
decreased heart weight 2 | 44
decreased lymphocyte cell numb... 2 | 9
decreased mature B cell number 2 | 25
decreased monocyte cell number 2 | 28
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
enlarged lymph nodes 2 | 27
increased Ly6C low monocyte nu... 2 | 8
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating amylase ... 2 | 13
increased circulating calcium ... 2 | 32
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased effector memory CD4-... 2 | 15
increased heart weight 2 | 37
increased neutrophil cell numb... 2 | 15
limb grasping 2 | 35
male infertility 2 | 62
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased NK cell number 1 | 16
decreased cervical vertebrae n... 1 | 12
decreased circulating magnesiu... 1 | 11
decreased eosinophil cell numb... 1 | 41
embryonic growth retardation 1 | 28
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18
increased body length 1 | 20
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 9
straub tail 1 | 26

Disease

ovarian cancer 291 | 8,484
osteosarcoma 235 | 7,933
psoriasis 211 | 6,685
glioblastoma 206 | 5,572
medulloblastoma, large-cell 206 | 6,234
lung cancer 202 | 4,466
Cancer 183 | 2,346
atypical teratoid / rhabdoid tumor 125 | 4,369
malignant mesothelioma 121 | 3,162
non-small cell lung cancer 119 | 2,798
lung carcinoma 118 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 115 | 3,289
pilocytic astrocytoma 115 | 3,086
Breast cancer 111 | 3,094
invasive ductal carcinoma 107 | 2,950
lung adenocarcinoma 107 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 105 | 2,988
pediatric high grade glioma 101 | 2,712
pancreatic cancer 97 | 2,300
oligodendroglioma 96 | 2,849
interstitial cystitis 94 | 2,299
subependymal giant cell astrocytoma 94 | 2,287
primitive neuroectodermal tumor 88 | 3,031
ulcerative colitis 87 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 86 | 2,956
tuberculosis 78 | 1,557
pituitary cancer 76 | 1,972
group 3 medulloblastoma 74 | 2,254
ependymoma 71 | 2,514
breast carcinoma 67 | 1,614
adult high grade glioma 66 | 2,148
astrocytic glioma 66 | 2,241
diabetes mellitus 64 | 1,663
ductal carcinoma in situ 64 | 1,745
colon cancer 62 | 1,475
cutaneous lupus erythematosus 62 | 1,056
group 4 medulloblastoma 62 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,795
cystic fibrosis 61 | 1,665
Pick disease 59 | 1,893
Carcinoma 58 | 2,147
Multiple myeloma 58 | 1,327
Rheumatoid Arthritis 56 | 1,160
adrenocortical carcinoma 52 | 1,427
juvenile dermatomyositis 50 | 1,189
posterior fossa group A ependymoma 50 | 1,511
primary pancreatic ductal adenocarcinoma 50 | 1,271
nasopharyngeal carcinoma 49 | 1,056
astrocytoma 46 | 1,493
dermatomyositis 46 | 933
sonic hedgehog group medulloblastoma 44 | 1,482
acute quadriplegic myopathy 42 | 1,157
spina bifida 42 | 1,064
Alzheimer's disease 41 | 644
atypical teratoid/rhabdoid tumor 41 | 1,095
esophageal adenocarcinoma 41 | 737
gastric carcinoma 41 | 832
medulloblastoma 41 | 1,524
posterior fossa group B ependymoma 41 | 1,530
primary Sjogren syndrome 39 | 789
Prostatic Neoplasms 36 | 471
Multiple Sclerosis 35 | 498
Waldenstrons macroglobulinemia 35 | 765
Atopic dermatitis 34 | 944
Mammary Neoplasms 34 | 410
aldosterone-producing adenoma 34 | 664
active Crohn's disease 31 | 918
Vascular disease 28 | 281
Stomach Neoplasms 26 | 282
acute myeloid leukemia 26 | 780
hepatocellular carcinoma 26 | 532
tuberculosis and treatment for 6 months 26 | 686
IGA Glomerulonephritis 25 | 454
Kidney disease 25 | 396
Lung Neoplasms 25 | 171
non-small cell lung carcinoma 25 | 413
pancreatic carcinoma 25 | 567
Asthma 24 | 349
Down syndrome 24 | 548
Hypersensitivity reaction type II disease 24 | 235
Obesity 24 | 616
Arthritis 23 | 248
Duchenne muscular dystrophy 23 | 602
non primary Sjogren syndrome sicca 23 | 840
active ulcerative colitis 22 | 477
progressive supranuclear palsy 22 | 674
Colorectal Neoplasms 21 | 217
Neurodegenerative disease 21 | 383
Amyotrophic Lateral Sclerosis 20 | 431
Crohn's disease 20 | 304
Melanoma 20 | 261
Schizophrenia 20 | 501
gastric cancer 20 | 430
mucosa-associated lymphoid tissue lymphoma 20 | 480
Parkinson's disease 19 | 364
Renal Cell Carcinoma 19 | 199
sarcoidosis 19 | 358
Colonic Neoplasms 18 | 126
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
Intellectual disability 17 | 573

Tissue

Female tissues 502 | 18,647
Nervous System 500 | 18,561
Digestive Tract 497 | 18,473
Blood and immune system 496 | 17,995
Endocrine System 495 | 18,512
Cardiovascular System 493 | 17,958
Urinary Tract 492 | 18,444
Liver and Pancreas 491 | 18,136
Skin and soft tissues 491 | 18,115
Male tissues 488 | 17,969
Respiratory system 486 | 17,484

Target Family

Non-IDG 305 | 11,971
Enzyme 96 | 4,146
Kinase 61 | 634
Transcription Factor 21 | 1,400
Epigenetic 8 | 242
GPCR 6 | 406
Ion Channel 3 | 341
Transporter 3 | 473
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

GO Process

apoptotic process 506 | 506
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628