Development Level

Tbio 24 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
hemorrhage 3 | 23
increased or absent threshold ... 2 | 101
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal iris pigmentation 1 | 4
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal outer ear morphology 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased bone mineral content 1 | 151
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
pale liver 1 | 6
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 15 | 8,520
Carcinoma 13 | 11,493
atypical teratoid / rhabdoid tumor 13 | 5,112
medulloblastoma, large-cell 13 | 6,241
osteosarcoma 11 | 7,950
adult high grade glioma 10 | 3,801
Hermansky-Pudlak syndrome 9 | 42
glioblastoma 9 | 5,792
ependymoma 8 | 4,679
Astrocytoma, Pilocytic 7 | 3,081
Platelet storage pool deficiency 7 | 21
Schizophrenia 7 | 1,160
group 3 medulloblastoma 7 | 4,104
lung cancer 7 | 4,740
Autosomal recessive predisposition 6 | 1,442
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
Neurodegenerative disease 5 | 414
astrocytic glioma 5 | 2,597
pituitary cancer 5 | 1,972
Hermanski-Pudlak Syndrome 4 | 8
Hyperreflexia 4 | 209
Nystagmus 4 | 317
Pick disease 4 | 1,894
group 4 medulloblastoma 4 | 1,855
hereditary spastic paraplegia 4 | 318
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
tuberculosis 4 | 2,010
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Babinski Reflex 3 | 100
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Congenital pes cavus 3 | 88
Decreased number of large and small myelinated fibers 3 | 20
Decreased tendon reflex 3 | 122
Degeneration of the lateral corticospinal tracts 3 | 6
Depressive disorder 3 | 409
Highly variable severity 3 | 157
Intellectual disability 3 | 1,016
Monoparesis - leg 3 | 27
Neuropathy 3 | 261
Oculocutaneous albinism 3 | 29
Paraplegia 3 | 74
Proteinuria 3 | 144
Reflex, Deep Tendon, Absent 3 | 92
Rheumatoid arthritis 3 | 1,191
Spastic Paraplegia 3 | 42
Spastic gait 3 | 23
Sphincter disturbances 3 | 16
Variable expressivity 3 | 157
Weakness of lower limb 3 | 27
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
medulloblastoma 3 | 720
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
Amyotrophic lateral sclerosis 2 | 451
Atherosclerosis 2 | 291
Atrophy of cerebellum 2 | 103
Cerebellar degeneration 2 | 103
Cerebral atrophy 2 | 178
Chronic progressive external ophthalmoplegia 2 | 26
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Distal amyotrophy 2 | 51
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Epilepsy 2 | 792
Heart failure 2 | 162
Huntington's disease 2 | 76
Infratentorial atrophy 2 | 103
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Lower limb spasticity 2 | 10
Major Depressive Disorder 2 | 301
Mental Depression 2 | 333
Motor delay 2 | 147
Motor neuron disease 2 | 49
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
No development of motor milestones 2 | 147
Progressive disorder 2 | 142
Skeletal muscle atrophy 2 | 139
Slow progression 2 | 89
Type 2 diabetes mellitus 2 | 272
Unipolar Depression 2 | 250
Urgency of micturition 2 | 14
Urinary Incontinence 2 | 50
Vascular disease 2 | 319
aldosterone-producing adenoma 2 | 665
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
muscle degeneration 2 | 139
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 24 | 15,192

Target Family

Non-IDG 23 | 12,091
Enzyme 3 | 4,145

GO Process

anterograde axonal transport 26 | 26
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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