Development Level

Tbio 66 | 10,625
Tchem 10 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 4 | 260
abnormal embryo size 2 | 112
abnormal facial morphology 2 | 9
cleft palate 2 | 6
decreased lean body mass 2 | 195
increased or absent threshold ... 2 | 128
short snout 2 | 4
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal respiratory quotient 1 | 9
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
curly tail 1 | 1
cyanosis 1 | 6
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating aspartat... 1 | 17
increased circulating creatini... 1 | 29
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
kinked tail 1 | 3
microphthalmia 1 | 15
shortened head 1 | 2
small spleen 1 | 11
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

osteosarcoma 45 | 7,933
psoriasis 42 | 6,685
ovarian cancer 39 | 8,491
glioblastoma 38 | 5,572
medulloblastoma, large-cell 35 | 6,234
atypical teratoid / rhabdoid tumor 31 | 4,369
Cancer 27 | 2,346
malignant mesothelioma 27 | 3,163
lung cancer 22 | 4,473
Breast cancer 20 | 3,098
invasive ductal carcinoma 19 | 2,950
adult high grade glioma 18 | 2,148
interstitial cystitis 18 | 2,299
oligodendroglioma 18 | 2,849
cutaneous lupus erythematosus 17 | 1,056
pancreatic cancer 17 | 2,300
primitive neuroectodermal tumor 17 | 3,031
Carcinoma 14 | 2,147
group 4 medulloblastoma 14 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
pituitary cancer 14 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
non-small cell lung cancer 13 | 2,798
pediatric high grade glioma 13 | 2,712
posterior fossa group A ependymoma 13 | 1,511
ductal carcinoma in situ 12 | 1,745
ependymoma 12 | 2,514
lung adenocarcinoma 12 | 2,714
pilocytic astrocytoma 12 | 3,086
subependymal giant cell astrocytoma 12 | 2,287
cystic fibrosis 11 | 1,670
group 3 medulloblastoma 11 | 2,254
sonic hedgehog group medulloblastoma 11 | 1,482
Rheumatoid Arthritis 10 | 1,170
breast carcinoma 10 | 1,614
primary pancreatic ductal adenocarcinoma 10 | 1,271
Craniofacial Abnormalities 9 | 147
astrocytic glioma 9 | 2,241
colon cancer 9 | 1,475
VACTERL association 8 | 23
acute myeloid leukemia 8 | 785
posterior fossa group B ependymoma 8 | 1,530
ulcerative colitis 8 | 2,087
Atopic dermatitis 7 | 944
Cleft palate 7 | 125
Pick disease 7 | 1,893
Polydactyly 7 | 93
adrenocortical carcinoma 7 | 1,427
spina bifida 7 | 1,064
Alzheimer's disease 6 | 644
Esophageal atresia 6 | 25
acute quadriplegic myopathy 6 | 1,157
astrocytoma 6 | 1,493
gastric carcinoma 6 | 832
lung carcinoma 6 | 2,844
Female Urogenital Diseases 5 | 18
Waldenstrons macroglobulinemia 5 | 764
atypical teratoid/rhabdoid tumor 5 | 1,095
diabetes mellitus 5 | 1,663
juvenile dermatomyositis 5 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Amyotrophic Lateral Sclerosis 4 | 432
Cleft Lip 4 | 91
Clubfoot 4 | 35
Endometriosis 4 | 535
Holoprosencephaly 4 | 52
Hypospadias 4 | 65
Obesity 4 | 616
Prostatic Neoplasms 4 | 471
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
active ulcerative colitis 4 | 477
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
inflammatory breast cancer 4 | 404
medulloblastoma 4 | 1,524
nasopharyngeal carcinoma 4 | 1,056
neural tube defect 4 | 8
non primary Sjogren syndrome sicca 4 | 840
tuberculosis and treatment for 6 months 4 | 686
Acquired metabolic disease 3 | 267
Bladder Neoplasm 3 | 109
Craniosynostosis 3 | 47
Diabetes Mellitus, Non-Insulin-Dependent 3 | 161
Down syndrome 3 | 548
Hypertension 3 | 293
Kidney disease 3 | 397
Leukemia 3 | 88
Multiple myeloma 3 | 1,327
Neural Tube Defects 3 | 31
Osteoporosis 3 | 259
Prostate cancer 3 | 172
Synostosis 3 | 18
Type 2 diabetes mellitus 3 | 192
aldosterone-producing adenoma 3 | 664
chronic lymphosyte leukemia 3 | 232
fibroadenoma 3 | 557
head and neck cancer 3 | 270
primary Sjogren syndrome 3 | 788

Tissue

Digestive Tract 78 | 18,472
Male tissues 78 | 17,968
Female tissues 77 | 18,646
Nervous System 77 | 18,560
Endocrine System 76 | 18,511
Liver and Pancreas 76 | 18,135
Skin and soft tissues 76 | 18,114
Urinary Tract 76 | 18,443
Blood and immune system 74 | 17,994
Cardiovascular System 74 | 17,957
Respiratory system 71 | 17,483

Target Family

Transcription Factor 51 | 1,400
Non-IDG 12 | 11,969
Kinase 6 | 634
Enzyme 3 | 4,146
Epigenetic 3 | 242
GPCR 2 | 408
Nuclear Receptor 2 | 48

GO Process

anterior-posterior pattern spe... 79 | 79
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein Hox-A2 HOXA2 Tbio Transcription Factor -2.28221 194.5 72
Homeobox protein Hox-A3 HOXA3 Tbio Transcription Factor -1.62995 43.1 146
Vang-like protein 2 VANGL2 Tbio Non-IDG -2.26133 182.3 138
Pre-B-cell leukemia transcription factor 1 PBX1 Tbio Transcription Factor -2.29016 188.5 219
Cell adhesion molecule-related/down-regulated by oncogenes CDON Tbio Non-IDG -2.63973 437.0 112
Homeobox protein Hox-C10 HOXC10 Tbio Transcription Factor -1.15036 14.8 257
T-box transcription factor TBX1 TBX1 Tbio Transcription Factor -1.96037 90.3 180
Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 Tbio GPCR -1.44011 31.7 110
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.63610 415.3 337
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62936 4.93 166