Development Level

Tbio 66 | 11,651
Tchem 8 | 1,388
Tclin 2 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 3 | 220
abnormal facial morphology 2 | 17
abnormal snout morphology 2 | 23
cleft palate 2 | 8
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
curly tail 1 | 1
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased kidney weight 1 | 1
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased heart rate variabili... 1 | 7
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
kinked tail 1 | 2
male infertility 1 | 123
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
small spleen 1 | 19
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 50 | 11,493
osteosarcoma 44 | 7,950
psoriasis 40 | 6,694
ovarian cancer 38 | 8,520
glioblastoma 37 | 5,792
atypical teratoid / rhabdoid tumor 35 | 5,112
medulloblastoma, large-cell 35 | 6,241
Cancer 29 | 2,499
ependymoma 26 | 4,679
malignant mesothelioma 25 | 3,232
group 3 medulloblastoma 23 | 4,104
adult high grade glioma 22 | 3,801
lung cancer 22 | 4,740
Breast cancer 20 | 3,578
invasive ductal carcinoma 18 | 2,951
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
interstitial cystitis 17 | 2,312
primitive neuroectodermal tumor 17 | 3,035
cutaneous lupus erythematosus 16 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pituitary cancer 14 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
non-small cell lung cancer 13 | 2,890
Astrocytoma, Pilocytic 12 | 3,081
Kidney cancer 12 | 2,613
ductal carcinoma in situ 12 | 1,745
lung adenocarcinoma 12 | 2,716
subependymal giant cell astrocytoma 12 | 2,287
Short stature 11 | 531
astrocytic glioma 11 | 2,597
cystic fibrosis 11 | 1,696
Rheumatoid arthritis 10 | 1,191
group 4 medulloblastoma 10 | 1,855
Craniofacial Abnormalities 9 | 151
Intellectual disability 9 | 1,016
breast carcinoma 9 | 1,638
Orbital separation excessive 8 | 244
VACTERL association 8 | 26
Ventricular Septal Defects 8 | 119
acute myeloid leukemia 8 | 783
colon cancer 8 | 1,478
pediatric high grade glioma 8 | 1,064
primary pancreatic ductal adenocarcinoma 8 | 1,109
Cleft Palate 7 | 271
Dull intelligence 7 | 645
Gastrointestinal Stromal Tumors 7 | 48
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Pick disease 7 | 1,894
Poor school performance 7 | 645
Schizophrenia 7 | 1,160
adrenocortical carcinoma 7 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
spina bifida 7 | 1,074
ulcerative colitis 7 | 1,819
Alzheimer's disease 6 | 658
Atopic dermatitis 6 | 952
Autosomal recessive predisposition 6 | 1,442
Polydactyly 6 | 107
Small head 6 | 374
acute quadriplegic myopathy 6 | 1,158
diabetes mellitus 6 | 1,728
gastric carcinoma 6 | 807
lung carcinoma 6 | 2,843
Abnormally small eyeball 5 | 97
Bilateral fifth finger clinodactyly 5 | 110
Cognitive delay 5 | 608
Craniosynostosis 5 | 74
Cryptorchidism 5 | 296
Curvature of little finger 5 | 110
Decreased size of eyeball 5 | 97
Epilepsy 5 | 792
Esophageal atresia 5 | 43
Female Urogenital Diseases 5 | 18
Global developmental delay 5 | 608
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Microphthalmos 5 | 100
Obesity 5 | 678
Patent ductus arteriosus 5 | 90
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Syndactyly 5 | 88
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 764
hand-foot-genital syndrome 5 | 9
juvenile dermatomyositis 5 | 1,187
medulloblastoma 5 | 720
Anus, Imperforate 4 | 46
Cleft Lip 4 | 141
Congenital hypoplasia of penis 4 | 176
Endometriosis 4 | 540
Uranostaphyloschisis 4 | 167
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
nasopharyngeal carcinoma 4 | 1,058

Tissue

Endocrine System 76 | 18,159
Skin and soft tissues 75 | 17,230
Digestive Tract 74 | 17,369
Female tissues 74 | 17,400
Urinary Tract 73 | 16,678
Male tissues 70 | 17,142
Blood and immune system 68 | 16,909
Liver and Pancreas 62 | 16,750
Nervous System 60 | 16,725
Respiratory system 60 | 16,393
Cardiovascular System 51 | 15,192

Target Family

Transcription Factor 49 | 1,400
Non-IDG 12 | 12,091
Kinase 6 | 634
Enzyme 3 | 4,145
Epigenetic 3 | 242
GPCR 2 | 408
Nuclear Receptor 2 | 48

GO Process

anterior-posterior pattern spe... 77 | 77
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Homeobox protein Hox-D10 HOXD10 Tbio Transcription Factor -1.78620 51.3 214
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.80737 619.7 475
Pre-B-cell leukemia transcription factor 1 PBX1 Tbio Transcription Factor -2.30640 200.0 232
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.65413 5.10 194
Cell adhesion molecule-related/down-regulated by oncogenes CDON Tbio Non-IDG -2.67247 471.8 128
Homeobox protein Hox-C10 HOXC10 Tbio Transcription Factor -1.24313 19.3 290
Vang-like protein 2 VANGL2 Tbio Non-IDG -2.29322 199.6 158
Neurogenic differentiation factor 1 NEUROD1 Tbio Transcription Factor -2.56661 344.4 371
Cerberus CER1 Tbio Non-IDG -2.32331 194.4 188