Development Level

Tbio 139 | 11,178
Tchem 63 | 1,885
Tclin 16 | 612
Tdark 2 | 6,569

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to t... 9 | 278
abnormal embryo size 7 | 220
preweaning lethality, incomple... 7 | 499
abnormal bone structure 6 | 187
abnormal heart morphology 6 | 162
enlarged heart 6 | 210
decreased lean body mass 5 | 135
increased total body fat amoun... 5 | 134
abnormal neural tube closure 4 | 46
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
pale yolk sac 4 | 25
abnormal forebrain development 3 | 20
abnormal locomotor behavior 3 | 24
abnormal pericardium morpholog... 3 | 26
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
hydrometra 3 | 53
impaired glucose tolerance 3 | 75
increased circulating alkaline... 3 | 122
increased lean body mass 3 | 172
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
pallor 3 | 34
abnormal behavior 2 | 298
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal retinal vasculature m... 2 | 27
decreased IgG1 level 2 | 8
decreased bone mineral content 2 | 151
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased lymphocyte cell numb... 2 | 83
decreased red blood cell distr... 2 | 41
decreased spleen weight 2 | 10
impaired righting response 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
short tibia 2 | 97
small seminal vesicle 2 | 10
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart looping 1 | 5
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged stomach 1 | 2
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
iris synechia 1 | 3
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
small thymus 1 | 16
thin ventricular wall 1 | 24
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 144 | 11,192
ovarian cancer 136 | 8,297
psoriasis 109 | 6,514
osteosarcoma 103 | 7,766
Cancer 97 | 2,388
glioblastoma 97 | 5,635
lung cancer 92 | 4,607
medulloblastoma, large-cell 81 | 6,086
Breast cancer 79 | 3,469
invasive ductal carcinoma 76 | 2,867
malignant mesothelioma 74 | 3,135
ependymoma 72 | 4,559
atypical teratoid / rhabdoid tumor 70 | 4,971
interstitial cystitis 70 | 2,237
lung adenocarcinoma 68 | 2,627
intraductal papillary-mucinous adenoma (IPMA) 67 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 65 | 3,204
lung carcinoma 64 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 63 | 2,902
non-small cell lung cancer 62 | 2,799
pancreatic cancer 59 | 2,322
Astrocytoma, Pilocytic 57 | 3,006
adult high grade glioma 54 | 3,701
cystic fibrosis 54 | 1,629
breast carcinoma 52 | 1,589
group 3 medulloblastoma 47 | 4,002
ulcerative colitis 46 | 1,765
oligodendroglioma 45 | 2,768
Kidney cancer 44 | 2,548
pituitary cancer 43 | 1,915
ductal carcinoma in situ 39 | 1,686
subependymal giant cell astrocytoma 39 | 2,230
tuberculosis 39 | 1,963
primitive neuroectodermal tumor 38 | 2,957
Breast Neoplasms 36 | 423
colon cancer 36 | 1,428
diabetes mellitus 36 | 1,683
gastric carcinoma 36 | 781
Mammary Neoplasms 35 | 403
adrenocortical carcinoma 33 | 1,385
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,911
group 4 medulloblastoma 31 | 1,806
Hypertension 29 | 372
Schizophrenia 29 | 1,136
astrocytic glioma 29 | 2,530
primary pancreatic ductal adenocarcinoma 29 | 1,071
juvenile dermatomyositis 28 | 1,147
Obesity 26 | 655
Vascular disease 26 | 294
astrocytoma 24 | 1,113
cutaneous lupus erythematosus 24 | 1,016
Liver Cirrhosis, Experimental 23 | 733
Kidney disease 22 | 411
Autosomal recessive predisposition 21 | 1,407
Bipolar Disorder 21 | 646
Prostatic Neoplasms 21 | 472
nasopharyngeal carcinoma 20 | 1,024
pediatric high grade glioma 20 | 1,035
Hypertensive disease 19 | 278
Rheumatoid arthritis 19 | 1,156
acute quadriplegic myopathy 19 | 1,133
aldosterone-producing adenoma 19 | 646
dermatomyositis 19 | 941
Atherosclerosis 18 | 276
Heart disease 18 | 288
Intellectual disability 18 | 998
Melanoma 18 | 689
Multiple myeloma 18 | 1,296
Pick disease 18 | 1,856
spina bifida 18 | 1,053
Alzheimer's disease 17 | 640
Duchenne muscular dystrophy 17 | 587
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 492
fibroadenoma 17 | 538
Atopic dermatitis 16 | 915
Down syndrome 16 | 480
Endometriosis 16 | 521
Epilepsy 16 | 775
Seizures 16 | 584
Arthritis 15 | 276
Liver cancer 15 | 589
Lung Neoplasms 15 | 217
active ulcerative colitis 15 | 736
esophageal adenocarcinoma 15 | 696
urothelial carcinoma 15 | 303
Asthma 14 | 370
Coronary artery disease 14 | 253
Lung disease 14 | 135
active Crohn's disease 14 | 882
mucosa-associated lymphoid tissue lymphoma 14 | 473
Cleft Palate 13 | 265
Depressive disorder 13 | 401
Dull intelligence 13 | 634
Low intelligence 13 | 634
Mental Retardation 13 | 634
Mental deficiency 13 | 634
Multiple Sclerosis 13 | 527
Polycystic ovary syndrome 13 | 348
Poor school performance 13 | 634
hepatocellular carcinoma 13 | 536

Tissue

Digestive Tract 217 | 17,369
Endocrine System 217 | 18,159
Liver and Pancreas 217 | 16,750
Female tissues 215 | 17,400
Skin and soft tissues 215 | 17,230
Urinary Tract 215 | 16,678
Blood and immune system 213 | 16,909
Male tissues 213 | 17,142
Respiratory system 211 | 16,393
Nervous System 210 | 16,725
Cardiovascular System 199 | 15,192

Target Family

Non-IDG 115 | 12,091
Enzyme 42 | 4,145
Transcription Factor 26 | 1,400
Kinase 25 | 634
GPCR 7 | 408
Epigenetic 2 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Process

angiogenesis 220 | 220
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Heparan-sulfate 6-O-sulfotransferase 1 HS6ST1 Tbio Enzyme -1.74222 59.7 70
Tumor necrosis factor alpha-induced protein 2 TNFAIP2 Tbio Non-IDG -1.79491 59.2 122
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159
Cytochrome P450 1B1 CYP1B1 Tchem Non-IDG -2.93702 904.4 260
Rho GTPase-activating protein 24 ARHGAP24 Tbio Enzyme -1.07229 15.5 169
Angiogenic factor with G patch and FHA domains 1 AGGF1 Tbio Non-IDG -1.25215 22.4 195
SH2 domain-containing adapter protein B SHB Tbio Non-IDG -2.19060 169.7 209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 PLCD3 Tbio Enzyme -1.21205 17.5 66