Development Level

Tbio 29 | 10,625
Tchem 10 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, incomple... 2 | 260
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal head morphology 1 | 10
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal social-conspecific in... 1 | 3
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
embryonic lethality prior to t... 1 | 187
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating glycerol... 1 | 11
increased grip strength 1 | 83
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
pale liver 1 | 5
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
preweaning lethality, complete... 1 | 633

Disease

ovarian cancer 31 | 8,491
osteosarcoma 26 | 7,933
medulloblastoma, large-cell 19 | 6,234
lung cancer 18 | 4,473
atypical teratoid / rhabdoid tumor 17 | 4,369
glioblastoma 17 | 5,572
psoriasis 17 | 6,685
Cancer 16 | 2,346
Breast cancer 15 | 3,098
malignant mesothelioma 15 | 3,163
Carcinoma 12 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
primitive neuroectodermal tumor 12 | 3,031
Endometriosis 10 | 535
Mammary Neoplasms 10 | 410
astrocytoma 10 | 1,493
astrocytic glioma 9 | 2,241
Prostate cancer 8 | 172
Rheumatoid Arthritis 8 | 1,170
dermatomyositis 8 | 966
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
invasive ductal carcinoma 8 | 2,950
oligodendroglioma 8 | 2,849
Multiple myeloma 7 | 1,327
Prostatic Neoplasms 7 | 471
adrenocortical carcinoma 7 | 1,427
adult high grade glioma 7 | 2,148
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
lung adenocarcinoma 7 | 2,714
non-small cell lung cancer 7 | 2,798
pituitary cancer 7 | 1,972
Liver carcinoma 6 | 217
Pick disease 6 | 1,893
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
medulloblastoma 6 | 1,524
Intellectual disability 5 | 573
Waldenstrons macroglobulinemia 5 | 764
active Crohn's disease 5 | 918
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 2,514
group 3 medulloblastoma 5 | 2,254
nasopharyngeal carcinoma 5 | 1,056
pilocytic astrocytoma 5 | 3,086
posterior fossa group B ependymoma 5 | 1,530
ulcerative colitis 5 | 2,087
Mammary Neoplasms, Experimental 4 | 149
Pancreatic Neoplasm 4 | 79
breast carcinoma 4 | 1,614
cystic fibrosis 4 | 1,670
diabetes mellitus 4 | 1,663
hepatocellular carcinoma 4 | 550
juvenile dermatomyositis 4 | 1,189
pancreatic cancer 4 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
pediatric high grade glioma 4 | 2,712
spina bifida 4 | 1,064
tuberculosis 4 | 1,563
Adenocarcinoma 3 | 115
Animal Mammary Neoplasms 3 | 135
Atopic dermatitis 3 | 944
Bladder Neoplasm 3 | 109
Crohn's disease 3 | 304
Obesity 3 | 616
Peripheral Neuropathy 3 | 303
Urinary bladder cancer 3 | 34
aldosterone-producing adenoma 3 | 664
cutaneous lupus erythematosus 3 | 1,056
gastric cancer 3 | 436
gastric carcinoma 3 | 832
interstitial cystitis 3 | 2,299
lung carcinoma 3 | 2,844
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
ovarian neoplasm 3 | 97
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
sonic hedgehog group medulloblastoma 3 | 1,482
subependymal giant cell astrocytoma 3 | 2,287
Adenoid Cystic Carcinoma 2 | 99
Alzheimer's disease 2 | 644
Amyotrophic Lateral Sclerosis 2 | 432
Autistic Disorder 2 | 320
Craniofacial Abnormalities 2 | 147
Disease Progression 2 | 125
Drug-Induced Liver Injury 2 | 118
Huntington's disease 2 | 72
Kennedy's disease 2 | 13
Leukemia 2 | 88
Liver cancer 2 | 31
Male infertility 2 | 170
Malignant neoplasm of prostate 2 | 67
Stomach Neoplasms 2 | 282
active ulcerative colitis 2 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
chronic lymphosyte leukemia 2 | 232
hereditary spastic paraplegia 2 | 313
primary Sjogren syndrome 2 | 788
urothelial carcinoma 2 | 318

Tissue

Liver and Pancreas 40 | 18,135
Cardiovascular System 39 | 17,957
Digestive Tract 39 | 18,472
Endocrine System 39 | 18,511
Female tissues 39 | 18,646
Male tissues 39 | 17,968
Nervous System 39 | 18,560
Respiratory system 39 | 17,483
Skin and soft tissues 39 | 18,114
Urinary Tract 39 | 18,443
Blood and immune system 38 | 17,994

Target Family

Enzyme 15 | 4,146
Non-IDG 15 | 11,969
Epigenetic 4 | 242
Transcription Factor 4 | 1,400
Kinase 1 | 634
Nuclear Receptor 1 | 48

GO Process

androgen receptor signaling pa... 40 | 40
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Transforming growth factor beta-1-induced transcript 1 protein TGFB1I1 Tbio Non-IDG -1.79827 82.2 142
Mediator of RNA polymerase II transcription subunit 1 MED1 Tbio Enzyme -1.88337 79.6 319
Death domain-associated protein 6 DAXX Tbio Non-IDG -2.30299 222.3 672
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.34642 231.0 276
Mediator of RNA polymerase II transcription subunit 4 MED4 Tbio Enzyme -1.64552 42.5 85
Androgen receptor AR Tclin Nuclear Receptor -3.79989 6683.7 1366
G1/S-specific cyclin-E1 CCNE1 Tchem Non-IDG -2.43326 239.2 741
Mediator of RNA polymerase II transcription subunit 24 MED24 Tbio Enzyme -1.15118 13.8 82
E3 SUMO-protein ligase PIAS1 PIAS1 Tbio Transcription Factor -1.83864 70.4 253