Development Level

Tbio 7 | 11,651
Tdark 3 | 6,593

IMPC Phenotype

decreased caudal vertebrae num... 2 | 53
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased circulating HDL chol... 1 | 80
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 8 | 11,493
ovarian cancer 6 | 8,520
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
glioblastoma 4 | 5,792
lung carcinoma 4 | 2,843
subependymal giant cell astrocytoma 4 | 2,287
adult high grade glioma 3 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
osteosarcoma 3 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Multiple myeloma 2 | 1,332
Placental insufficiency 2 | 18
Schizophrenia 2 | 1,160
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 4,104
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
3p- syndrome 1 | 21
ADULT syndrome 1 | 9
Achromatopsia 1 | 16
Aniridia 1 | 25
Autistic Disorder 1 | 364
COPD 1 | 118
Cardiovascular system disease 1 | 246
Congenital nystagmus 1 | 26
Down syndrome 1 | 499
Duchenne muscular dystrophy 1 | 601
Epilepsy 1 | 792
FOVEAL HYPOPLASIA 2 1 | 1
Foveal Hypoplasia and Anterior Segment Dysgenesis 1 | 1
Gaucher disease type 3 1 | 67
Guanidinoacetate methyltransferase deficiency 1 | 4
Klatskin's tumor 1 | 3
Liver neoplasms 1 | 130
Myocardial Ischemia 1 | 169
Pick disease 1 | 1,894
Tricuspid valve insufficiency 1 | 14
Waldenstrons macroglobulinemia 1 | 765
X-linked cerebral adrenoleukodystrophy 1 | 116
acute myeloid leukemia 1 | 783
astrocytic glioma 1 | 2,597
astrocytoma 1 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
breast carcinoma 1 | 1,638
chronic rhinosinusitis 1 | 512
fibroadenoma 1 | 559
gastric cancer 1 | 459
gastric carcinoma 1 | 807
group 4 medulloblastoma 1 | 1,855
hereditary spastic paraplegia 1 | 318
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
juvenile dermatomyositis 1 | 1,187
nasopharyngeal carcinoma 1 | 1,058
pancreatic cancer 1 | 2,398
primary Sjogren syndrome 1 | 735
tuberculosis 1 | 2,010
tuberculosis and treatment for 3 months 1 | 179

Tissue

Endocrine System 10 | 18,159
Nervous System 10 | 16,725
Blood and immune system 9 | 16,909
Digestive Tract 9 | 17,369
Male tissues 9 | 17,142
Cardiovascular System 8 | 15,192
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Transporter 10 | 473

GO Process

amino acid transmembrane trans... 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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