Development Level

Tbio 6 | 10,625
Tdark 3 | 7,003
Tchem 1 | 1,890

IMPC Phenotype

abnormal eye morphology 2 | 38
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased total body fat amoun... 2 | 186
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal eye size 1 | 11
abnormal femur morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
decreased CD4-positive, CD25-p... 1 | 24
decreased NK cell number 1 | 16
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
increased bone mineral density 1 | 52
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 6 | 8,491
psoriasis 6 | 6,685
medulloblastoma, large-cell 5 | 6,234
atypical teratoid / rhabdoid tumor 4 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
lung cancer 3 | 4,473
lung carcinoma 3 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
subependymal giant cell astrocytoma 3 | 2,287
Breast cancer 2 | 3,098
Pick disease 2 | 1,893
active Crohn's disease 2 | 918
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
colon cancer 2 | 1,475
glioblastoma 2 | 5,572
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
malignant mesothelioma 2 | 3,163
oligodendroglioma 2 | 2,849
osteosarcoma 2 | 7,933
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 1,530
3p- syndrome 1 | 21
ADULT syndrome 1 | 9
Achromatopsia 1 | 14
Adrenoleukodystrophy, Neonatal 1 | 13
Aniridia 1 | 26
COPD 1 | 116
Cardiovascular system disease 1 | 194
Congenital nystagmus 1 | 26
Down syndrome 1 | 548
Epilepsy 1 | 346
Foveal Hypoplasia and Anterior Segment Dysgenesis 1 | 1
Foveal hypoplasia 2 1 | 1
Gaucher disease type 3 1 | 76
Guanidinoacetate methyltransferase deficiency 1 | 4
IGA Glomerulonephritis 1 | 454
Infantile Refsum Disease (disorder) 1 | 13
Infantile refsum disease 1 | 23
Liver neoplasms 1 | 108
Multiple myeloma 1 | 1,327
Myocardial Ischemia 1 | 169
Neonatal adrenoleukodystrophy 1 | 14
PEROXISOME BIOGENESIS DISORDER 10A (ZELLWEGER) 1 | 1
Peroxisomal disease 1 | 20
Peroxisome Biogenesis Disorder 1A (Zellweger) 1 | 12
Peroxisome Biogenesis Disorder 3B 1 | 11
Peroxisome biogenesis disorder 10A 1 | 1
Peroxisome biogenesis disorder complementation group 12 1 | 1
Peroxisome biogenesis disorders 1 | 11
Pulmonary hypertension 1 | 52
Rhizomelic chondrodysplasia punctata 1 | 11
Tricuspid valve insufficiency 1 | 11
Waldenstrons macroglobulinemia 1 | 764
Zellweger Syndrome 1 | 38
active ulcerative colitis 1 | 477
acute myeloid leukemia 1 | 785
acute quadriplegic myopathy 1 | 1,157
astrocytic glioma 1 | 2,241
astrocytoma 1 | 1,493
chronic rhinosinusitis 1 | 512
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 2,514
gastric cancer 1 | 436
glioblastoma multiforme 1 | 347
group 3 medulloblastoma 1 | 2,254
group 4 medulloblastoma 1 | 1,875
hereditary spastic paraplegia 1 | 313
invasive ductal carcinoma 1 | 2,950
medulloblastoma 1 | 1,524
nasopharyngeal carcinoma 1 | 1,056
non-small cell lung cancer 1 | 2,798
pancreatic cancer 1 | 2,300
posterior fossa group A ependymoma 1 | 1,511
primary pancreatic ductal adenocarcinoma 1 | 1,271
progressive supranuclear palsy 1 | 674
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327
ulcerative colitis 1 | 2,087

Tissue

Blood and immune system 10 | 17,994
Cardiovascular System 10 | 17,957
Digestive Tract 10 | 18,472
Endocrine System 10 | 18,511
Female tissues 10 | 18,646
Liver and Pancreas 10 | 18,135
Male tissues 10 | 17,968
Nervous System 10 | 18,560
Respiratory system 10 | 17,483
Skin and soft tissues 10 | 18,114
Urinary Tract 10 | 18,443

Target Family

Transporter 9 | 473
Non-IDG 1 | 11,969

GO Process

amino acid transmembrane trans... 10 | 10
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

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