Development Level

Tbio 100 | 11,651
Tchem 44 | 1,388
Tclin 22 | 612
Tdark 1 | 6,593

Collection

GPCR: IDG Consortium (Targets) 3 | 126
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
decreased bone mineral content 4 | 151
edema 4 | 59
abnormal behavior 3 | 298
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
enlarged heart 3 | 210
abnormal testis morphology 2 | 43
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased exploration in new e... 2 | 11
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
hypoactivity 2 | 132
increased circulating triglyce... 2 | 42
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal limb bud morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
absent testes 1 | 6
absent vibrissae 1 | 12
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased coping response 1 | 4
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
lordosis 1 | 1
male infertility 1 | 123
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
shortened ST segment 1 | 10
small testis 1 | 58
vertebral transformation 1 | 12

Disease

Carcinoma 106 | 11,493
Cancer 98 | 2,499
psoriasis 98 | 6,694
ovarian cancer 95 | 8,520
osteosarcoma 75 | 7,950
glioblastoma 74 | 5,792
lung cancer 74 | 4,740
medulloblastoma, large-cell 69 | 6,241
ependymoma 61 | 4,679
atypical teratoid / rhabdoid tumor 60 | 5,112
diabetes mellitus 55 | 1,728
Schizophrenia 51 | 1,160
non-small cell lung cancer 47 | 2,890
Breast cancer 46 | 3,578
pancreatic cancer 46 | 2,398
malignant mesothelioma 45 | 3,232
Obesity 43 | 678
adult high grade glioma 43 | 3,801
invasive ductal carcinoma 41 | 2,951
lung adenocarcinoma 41 | 2,716
Astrocytoma, Pilocytic 40 | 3,081
cystic fibrosis 38 | 1,696
group 3 medulloblastoma 38 | 4,104
ulcerative colitis 38 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
primitive neuroectodermal tumor 37 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
tuberculosis 36 | 2,010
Autosomal recessive predisposition 34 | 1,442
Liver Cirrhosis, Experimental 34 | 769
lung carcinoma 34 | 2,843
oligodendroglioma 34 | 2,850
pituitary cancer 33 | 1,972
interstitial cystitis 32 | 2,312
Hypertension 31 | 396
subependymal giant cell astrocytoma 31 | 2,287
breast carcinoma 30 | 1,638
Hypertensive disease 28 | 292
Kidney disease 28 | 430
Prostatic Neoplasms 28 | 495
Atopic dermatitis 27 | 952
adrenocortical carcinoma 27 | 1,428
ductal carcinoma in situ 27 | 1,745
Alzheimer's disease 26 | 658
Depressive disorder 25 | 409
gastric carcinoma 25 | 807
Epilepsy 24 | 792
Rheumatoid arthritis 24 | 1,191
astrocytic glioma 24 | 2,597
colon cancer 24 | 1,478
Bipolar Disorder 23 | 666
Parkinson's disease 23 | 392
Seizures 23 | 596
astrocytoma 23 | 1,146
Asthma 22 | 385
Endometriosis 22 | 540
Heart disease 21 | 306
Kidney cancer 21 | 2,613
Lung Neoplasms 21 | 232
group 4 medulloblastoma 21 | 1,855
juvenile dermatomyositis 21 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
Breast Neoplasms 20 | 445
Cerebrovascular disease 20 | 238
Hyperglycemia 20 | 137
Mammary Neoplasms 20 | 425
Multiple Sclerosis 20 | 540
Atherosclerosis 19 | 291
Multiple myeloma 19 | 1,332
Toxic encephalopathy 19 | 141
Vascular disease 19 | 319
acute quadriplegic myopathy 19 | 1,158
Autistic Disorder 18 | 364
Cognitive delay 18 | 608
Diabetes Mellitus, Experimental 18 | 108
Global developmental delay 18 | 608
Intellectual disability 18 | 1,016
Mental and motor retardation 18 | 608
Coronary artery disease 17 | 268
Myocardial Infarction 17 | 151
cutaneous lupus erythematosus 17 | 1,057
nasopharyngeal carcinoma 17 | 1,058
Arthritis 16 | 290
Carcinoma, Hepatocellular 16 | 228
Down syndrome 16 | 499
Duchenne muscular dystrophy 16 | 601
Liver Cirrhosis 16 | 181
Liver carcinoma 16 | 240
Major Depressive Disorder 16 | 301
primary pancreatic ductal adenocarcinoma 16 | 1,109
Alcoholic Intoxication, Chronic 15 | 289
Liver disease 15 | 237
Short stature 15 | 531
Squamous cell carcinoma 15 | 129
Waldenstrons macroglobulinemia 15 | 765
esophageal adenocarcinoma 15 | 737
fibroadenoma 15 | 559
medulloblastoma 15 | 720
Low intelligence 14 | 645

Tissue

Endocrine System 160 | 18,159
Female tissues 155 | 17,400
Nervous System 154 | 16,725
Digestive Tract 153 | 17,369
Skin and soft tissues 153 | 17,230
Blood and immune system 152 | 16,909
Urinary Tract 151 | 16,678
Male tissues 150 | 17,142
Liver and Pancreas 148 | 16,750
Respiratory system 148 | 16,393
Cardiovascular System 142 | 15,192

Target Family

Non-IDG 70 | 12,091
Enzyme 47 | 4,145
Transcription Factor 19 | 1,400
GPCR 11 | 408
Kinase 9 | 634
Transporter 5 | 473
Epigenetic 3 | 242
Ion Channel 3 | 344

GO Process

aging 167 | 167
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 Tchem Enzyme -2.12624 141.3 310
F-box only protein 4 FBXO4 Tbio Non-IDG -1.07080 11.1 225
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.03585 113.9 202