Development Level

Tbio 18 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

hypoactivity 3 | 132
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased circulating serum al... 2 | 82
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged urinary bladder 1 | 8
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean platelet volume 1 | 45
prolonged RR interval 1 | 8
rib fusion 1 | 1
syndactyly 1 | 23
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 21 | 11,493
glioblastoma 17 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
osteosarcoma 15 | 7,950
medulloblastoma, large-cell 13 | 6,241
adult high grade glioma 12 | 3,801
ependymoma 12 | 4,679
group 3 medulloblastoma 12 | 4,104
oligodendroglioma 12 | 2,850
Autosomal recessive predisposition 10 | 1,442
astrocytic glioma 10 | 2,597
lung cancer 10 | 4,740
Astrocytoma, Pilocytic 9 | 3,081
lung carcinoma 9 | 2,843
psoriasis 9 | 6,694
subependymal giant cell astrocytoma 9 | 2,287
Seizures 8 | 596
ovarian cancer 8 | 8,520
Parkinson's disease 7 | 392
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Breast cancer 6 | 3,578
Cancer 6 | 2,499
Depressive disorder 6 | 409
Epilepsy 6 | 792
Kidney cancer 6 | 2,613
primitive neuroectodermal tumor 6 | 3,035
Cerebellar Ataxia 5 | 304
Dull intelligence 5 | 645
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Nystagmus 5 | 317
Pick disease 5 | 1,894
Poor school performance 5 | 645
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
pituitary cancer 5 | 1,972
Atrophy of cerebellum 4 | 103
Autistic Disorder 4 | 364
Cerebellar degeneration 4 | 103
Constipation 4 | 181
Infratentorial atrophy 4 | 103
Myoclonus 4 | 74
Neurodegenerative disease 4 | 414
Neuropathy 4 | 261
Obesity 4 | 678
Optic Atrophy 4 | 242
Schizophrenia 4 | 1,160
Tremor 4 | 113
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Action Tremor 3 | 22
Alcoholic Intoxication, Chronic 3 | 289
Amphetamine-Related Disorders 3 | 74
Anxiety 3 | 136
Anxiety disease 3 | 113
Atopic dermatitis 3 | 952
Attention deficit hyperactivity disorder 3 | 278
Babinski Reflex 3 | 100
Bipolar Disorder 3 | 666
Catalepsy 3 | 15
Cerebellar Dysmetria 3 | 56
Cerebral atrophy 3 | 178
Cognitive delay 3 | 608
Degenerative brain disorder 3 | 100
Deglutition Disorders 3 | 132
Delayed bone age 3 | 136
Dysarthria 3 | 192
Failure to gain weight 3 | 365
General anesthesia 3 | 53
Global developmental delay 3 | 608
Hepatomegaly 3 | 285
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hyperactive behavior 3 | 91
Hypothyroidism 3 | 122
Infantile onset 3 | 238
Liver cancer 3 | 604
Mental and motor retardation 3 | 608
Movement Disorders 3 | 55
Muscle Spasticity 3 | 195
Pain 3 | 103
Parkinsonism 3 | 18
Pediatric failure to thrive 3 | 365
Phenotypic variability 3 | 150
Splenomegaly 3 | 190
Supratentorial atrophy 3 | 94
Terminal tremor 3 | 20
diabetes mellitus 3 | 1,728
interstitial cystitis 3 | 2,312
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010
Electroencephalogram abnormal 2 | 101

Tissue

Endocrine System 27 | 18,159
Nervous System 26 | 16,725
Female tissues 24 | 17,400
Male tissues 24 | 17,142
Skin and soft tissues 24 | 17,230
Digestive Tract 23 | 17,369
Respiratory system 23 | 16,393
Blood and immune system 22 | 16,909
Liver and Pancreas 21 | 16,750
Urinary Tract 19 | 16,678
Cardiovascular System 17 | 15,192

Target Family

Non-IDG 12 | 12,091
Ion Channel 4 | 344
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400
GPCR 2 | 408
Kinase 2 | 634
Epigenetic 1 | 242

GO Process

adult walking behavior 27 | 27
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Glycine receptor subunit beta GLRB Tclin Ion Channel -1.28276 18.0 97
D(1A) dopamine receptor DRD1 Tclin GPCR -2.55049 294.2 485
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
Pro-thyrotropin-releasing hormone TRH Tbio Non-IDG -3.25312 1828.2 102
Spectrin beta chain, non-erythrocytic 4 SPTBN4 Tbio Non-IDG -1.35996 22.3 58
Sodium channel protein type 1 subunit alpha SCN1A Tclin Ion Channel -2.74061 554.6 131
Ubiquitin carboxyl-terminal hydrolase isozyme L1 UCHL1 Tchem Enzyme -3.16318 1414.2 1378