Development Level

Tchem 16 | 1,598
Tbio 13 | 11,445
Tclin 5 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal lens morphology 2 | 81
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
edema 1 | 59
hemorrhage 1 | 23
respiratory system phenotype 1 | 2

Disease

Carcinoma 27 | 11,493
ovarian cancer 20 | 8,520
Cancer 19 | 2,499
glioblastoma 19 | 5,792
medulloblastoma, large-cell 18 | 6,241
osteosarcoma 18 | 7,950
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 16 | 4,679
psoriasis 13 | 6,694
malignant mesothelioma 12 | 3,232
Kidney cancer 10 | 2,613
lung cancer 10 | 4,740
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
primitive neuroectodermal tumor 9 | 3,035
Breast cancer 8 | 3,578
astrocytic glioma 8 | 2,597
group 3 medulloblastoma 8 | 4,104
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
tuberculosis 8 | 2,010
Schizophrenia 7 | 1,160
Short stature 7 | 531
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
Alzheimer's disease 6 | 658
Autosomal recessive predisposition 6 | 1,442
Neurodegenerative disease 6 | 414
Rheumatoid arthritis 6 | 1,191
Toxic encephalopathy 6 | 141
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
ulcerative colitis 6 | 1,819
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Mental and motor retardation 5 | 608
Prostatic Neoplasms 5 | 495
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
gastric cancer 5 | 459
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Blepharoptosis 4 | 231
Breast Neoplasms 4 | 445
Byzanthine arch palate 4 | 194
Cleft Palate 4 | 271
Curvature of spine 4 | 282
Dementia 4 | 175
Depressive disorder 4 | 409
Hypoplastic mandible condyle 4 | 275
Liver Cirrhosis 4 | 181
Liver Cirrhosis, Experimental 4 | 769
Mammary Neoplasms 4 | 425
Mandibular hypoplasia 4 | 275
Mental Depression 4 | 333
Micrognathism 4 | 275
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Nerve Degeneration 4 | 121
Orbital separation excessive 4 | 244
Parkinson's disease 4 | 392
Pick disease 4 | 1,894
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Alcoholic Intoxication, Chronic 3 | 289
Bipolar Disorder 3 | 666
Cerebrovascular disease 3 | 238
Dull intelligence 3 | 645
Dysarthria 3 | 192
Epilepsy 3 | 792
Infantile onset 3 | 238
Low intelligence 3 | 645
Melanoma 3 | 711
Mental deficiency 3 | 645
Poor school performance 3 | 645
Psychotic Disorders 3 | 151
Status Epilepticus 3 | 98
Vascular disease 3 | 319
acute myeloid leukemia 3 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058
primary Sjogren syndrome 3 | 735
progressive supranuclear palsy 3 | 676

Tissue

Endocrine System 35 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Urinary Tract 33 | 16,678
Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230

Target Family

Kinase 14 | 634
Non-IDG 13 | 12,091
Enzyme 5 | 4,145
GPCR 3 | 408

GO Process

activation of MAPKK activity 35 | 35
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Disintegrin and metalloproteinase domain-containing protein 9 ADAM9 Tchem Enzyme -2.08807 122.3 258
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Tchem Kinase -1.18567 14.9 215
Mitogen-activated protein kinase kinase kinase 15 MAP3K15 Tchem Kinase -0.94156 6.81 97
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Proteinase-activated receptor 1 F2R Tclin GPCR -2.78393 551.0 453
MAP3K7 C-terminal-like protein MAP3K7CL Tdark Non-IDG -0.51188 3.20 110