Development Level

Tbio 36 | 11,651
Tchem 12 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal bone structure 3 | 187
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating triglyce... 2 | 79
impaired pupillary reflex 2 | 26
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal coping response 1 | 1
abnormal cornea morphology 1 | 31
abnormal digestive system phys... 1 | 1
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal iris pigmentation 1 | 4
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
absent startle reflex 1 | 24
cataract 1 | 92
corneal opacity 1 | 32
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
fused cornea and lens 1 | 5
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
iris synechia 1 | 3
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 41 | 11,493
ovarian cancer 33 | 8,520
osteosarcoma 30 | 7,950
glioblastoma 25 | 5,792
atypical teratoid / rhabdoid tumor 23 | 5,112
lung cancer 23 | 4,740
medulloblastoma, large-cell 23 | 6,241
psoriasis 22 | 6,694
Cancer 20 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
ependymoma 18 | 4,679
lung carcinoma 18 | 2,843
Astrocytoma, Pilocytic 17 | 3,081
malignant mesothelioma 17 | 3,232
pancreatic cancer 17 | 2,398
non-small cell lung cancer 16 | 2,890
Breast cancer 15 | 3,578
adult high grade glioma 15 | 3,801
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
subependymal giant cell astrocytoma 15 | 2,287
Kidney cancer 14 | 2,613
invasive ductal carcinoma 14 | 2,951
group 3 medulloblastoma 13 | 4,104
tuberculosis 13 | 2,010
diabetes mellitus 12 | 1,728
lung adenocarcinoma 12 | 2,716
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
group 4 medulloblastoma 11 | 1,855
interstitial cystitis 11 | 2,312
primary pancreatic ductal adenocarcinoma 11 | 1,109
ulcerative colitis 10 | 1,819
Pick disease 8 | 1,894
juvenile dermatomyositis 8 | 1,187
Bipolar Disorder 7 | 666
Liver Cirrhosis, Experimental 7 | 769
Rheumatoid arthritis 7 | 1,191
Schizophrenia 7 | 1,160
acute quadriplegic myopathy 7 | 1,158
breast carcinoma 7 | 1,638
pituitary cancer 7 | 1,972
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074
Hypertension 6 | 396
adrenocortical carcinoma 6 | 1,428
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
gastric carcinoma 6 | 807
mucosa-associated lymphoid tissue lymphoma 6 | 484
Breast Neoplasms 5 | 445
Neoplasm Invasiveness 5 | 161
Polycystic ovary syndrome 5 | 360
Prostatic Neoplasms 5 | 495
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
esophageal adenocarcinoma 5 | 737
pancreatic carcinoma 5 | 562
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pediatric high grade glioma 5 | 1,064
Amyotrophic lateral sclerosis 4 | 451
Duchenne muscular dystrophy 4 | 601
Heart disease 4 | 306
Intellectual disability 4 | 1,016
Mammary Neoplasms 4 | 425
Proteinuria 4 | 144
Renal Cell Carcinoma 4 | 214
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
fibroadenoma 4 | 559
medulloblastoma 4 | 720
posterior fossa group B ependymoma 4 | 416
progressive supranuclear palsy 4 | 676
Animal Mammary Neoplasms 3 | 136
Arthritis, Juvenile 3 | 126
Asthma 3 | 385
Autosomal recessive predisposition 3 | 1,442
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Cleft Palate 3 | 271
Crohn's disease 3 | 321
Endometrial cancer 3 | 311
Gastrointestinal stromal tumor 3 | 62
Juvenile arthritis 3 | 126
Kidney disease 3 | 430
Lung disease 3 | 142
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Multiple Sclerosis 3 | 540
Myocardial Infarction 3 | 151
Nonsyndromic deafness 3 | 142
Orbital separation excessive 3 | 244
Osteoporosis 3 | 363
Pancreatic Neuroendocrine Tumor 3 | 45
gastric cancer 3 | 459
nasopharyngeal carcinoma 3 | 1,058

Tissue

Blood and immune system 50 | 16,909
Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Urinary Tract 50 | 16,678
Female tissues 49 | 17,400
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Skin and soft tissues 49 | 17,230
Cardiovascular System 48 | 15,192
Liver and Pancreas 48 | 16,750
Respiratory system 48 | 16,393

Target Family

Non-IDG 26 | 12,091
Kinase 13 | 634
Enzyme 6 | 4,145
GPCR 3 | 408
Ion Channel 1 | 344
Transporter 1 | 473

GO Process

actin cytoskeleton reorganizat... 50 | 50
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
FERM, ARHGEF and pleckstrin domain-containing protein 2 FARP2 Tbio Non-IDG -0.69662 6.07 111
Alpha-parvin PARVA Tbio Non-IDG -2.38332 236.6 0
Gamma-parvin PARVG Tbio Non-IDG -0.73756 5.92 71
Beta-parvin PARVB Tbio Non-IDG -1.26717 17.4 137
Muskelin MKLN1 Tbio Non-IDG -1.08451 14.7 102
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.55166 363.0 320