Development Level

Tbio 134 | 10,625
Tchem 33 | 1,890
Tdark 5 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 9 | 633
decreased lean body mass 5 | 195
decreased lumbar vertebrae num... 4 | 62
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
short tibia 3 | 82
small testis 3 | 37
abnormal bone mineralization 2 | 55
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal testis morphology 2 | 30
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
prenatal lethality prior to he... 2 | 64
abnormal coat/ hair morphology 1 | 18
abnormal craniofacial morpholo... 1 | 12
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal facial morphology 1 | 9
abnormal head morphology 1 | 10
abnormal head shape 1 | 4
abnormal head size 1 | 1
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
anophthalmia 1 | 20
cleft palate 1 | 6
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased alpha-beta T cell nu... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glycerol... 1 | 19
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
facial cleft 1 | 3
female infertility 1 | 34
hyperactivity 1 | 108
hypoactivity 1 | 89
increased T cell number 1 | 15
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating glycerol... 1 | 11
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased lean body mass 1 | 107
increased rib number 1 | 41
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
microphthalmia 1 | 15
mydriasis 1 | 9
prenatal lethality 1 | 16
small adrenal glands 1 | 15
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 94 | 8,492
osteosarcoma 84 | 7,933
medulloblastoma, large-cell 74 | 6,234
psoriasis 67 | 6,685
glioblastoma 61 | 5,572
Cancer 52 | 2,346
atypical teratoid / rhabdoid tumor 51 | 4,369
lung cancer 51 | 4,473
Breast cancer 40 | 3,099
malignant mesothelioma 36 | 3,163
primitive neuroectodermal tumor 35 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
invasive ductal carcinoma 34 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
oligodendroglioma 33 | 2,849
ependymoma 32 | 2,514
non-small cell lung cancer 32 | 2,798
pilocytic astrocytoma 32 | 3,086
breast carcinoma 30 | 1,614
interstitial cystitis 30 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
astrocytic glioma 28 | 2,241
lung adenocarcinoma 28 | 2,714
Carcinoma 27 | 2,147
lung carcinoma 27 | 2,844
subependymal giant cell astrocytoma 26 | 2,287
adult high grade glioma 24 | 2,148
pediatric high grade glioma 24 | 2,712
ulcerative colitis 24 | 2,087
cystic fibrosis 23 | 1,670
group 4 medulloblastoma 23 | 1,875
group 3 medulloblastoma 22 | 2,254
pancreatic cancer 22 | 2,300
sonic hedgehog group medulloblastoma 22 | 1,482
medulloblastoma 20 | 1,524
primary pancreatic ductal adenocarcinoma 20 | 1,271
adrenocortical carcinoma 19 | 1,427
pituitary cancer 18 | 1,972
ductal carcinoma in situ 17 | 1,745
astrocytoma 16 | 1,493
juvenile dermatomyositis 16 | 1,189
Pick disease 15 | 1,893
posterior fossa group B ependymoma 15 | 1,530
colon cancer 14 | 1,475
dermatomyositis 14 | 967
cutaneous lupus erythematosus 13 | 1,056
Alzheimer's disease 12 | 644
Osteoporosis 12 | 259
Rheumatoid Arthritis 12 | 1,171
acute myeloid leukemia 12 | 785
acute quadriplegic myopathy 12 | 1,157
atypical teratoid/rhabdoid tumor 12 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Mammary Neoplasms 11 | 410
Multiple myeloma 11 | 1,328
diabetes mellitus 11 | 1,663
non primary Sjogren syndrome sicca 11 | 840
spina bifida 11 | 1,064
tuberculosis 10 | 1,563
Crohn's disease 9 | 304
Intellectual disability 9 | 573
esophageal adenocarcinoma 9 | 737
posterior fossa group A ependymoma 9 | 1,511
tuberculosis and treatment for 6 months 9 | 686
Colorectal Neoplasms 8 | 217
Parkinson's disease 8 | 364
Schizophrenia 8 | 503
Waldenstrons macroglobulinemia 8 | 765
fibroadenoma 8 | 557
Atopic dermatitis 7 | 944
Duchenne muscular dystrophy 7 | 602
Obesity 7 | 616
Stomach Neoplasms 7 | 282
progressive supranuclear palsy 7 | 674
Bipolar Disorder 6 | 266
Cleft palate 6 | 125
Kidney disease 6 | 397
Liver carcinoma 6 | 217
gastric carcinoma 6 | 832
hepatocellular carcinoma 6 | 550
nasopharyngeal carcinoma 6 | 1,056
primary Sjogren syndrome 6 | 789
sarcoidosis 6 | 368
Amyotrophic Lateral Sclerosis 5 | 432
Colonic Neoplasms 5 | 126
Craniofacial Abnormalities 5 | 147
Syndactyly 5 | 56
Tooth agenesis 5 | 38
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
non-inflammatory breast cancer 5 | 208
Adenoma 4 | 165
Down syndrome 4 | 548
Neurodegenerative disease 4 | 383
Prostatic Neoplasms 4 | 471
Type 2 diabetes mellitus 4 | 192
Vascular disease 4 | 281
chronic lymphocytic leukemia 4 | 244
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
urothelial carcinoma 4 | 318

Tissue

Digestive Tract 174 | 18,473
Endocrine System 174 | 18,512
Female tissues 174 | 18,647
Male tissues 174 | 17,969
Nervous System 174 | 18,561
Skin and soft tissues 174 | 18,115
Urinary Tract 174 | 18,444
Blood and immune system 173 | 17,995
Liver and Pancreas 173 | 18,136
Respiratory system 173 | 17,484
Cardiovascular System 172 | 17,958

Target Family

Non-IDG 107 | 11,969
Enzyme 27 | 4,146
Kinase 21 | 634
Transcription Factor 13 | 1,400
GPCR 4 | 408
Epigenetic 2 | 242
Transporter 1 | 473

GO Process

Wnt signaling pathway 175 | 175
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pygopus homolog 1 PYGO1 Tdark Epigenetic -0.48368 2.66 111
Leucine-rich repeat-containing G-protein coupled receptor 6 LGR6 Tbio GPCR -1.31264 22.5 138
Axin-2 AXIN2 Tchem Non-IDG -2.41017 219.7 225
Pituitary homeobox 2 PITX2 Tbio Transcription Factor -2.62459 433.8 185
LIM domain-binding protein 1 LDB1 Tbio Non-IDG -2.20381 158.5 181
E3 ubiquitin-protein ligase RNF146 RNF146 Tbio Enzyme -0.92024 8.53 46
Metalloprotease TIKI1 TRABD2A Tbio Enzyme -0.46489 2.79 48
Signal transducer CD24 CD24 Tbio Non-IDG 0.00000 0
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.89186 64.6 443
Sentrin-specific protease 2 SENP2 Tbio Enzyme -0.25795 1.43 271