Development Level

Tbio 87 | 10,625
Tchem 52 | 1,890
Tclin 14 | 602
Tdark 8 | 7,003

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 6 | 633
decreased body weight 3 | 174
decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
decreased T cell number 2 | 31
decreased bone mineral content 2 | 157
decreased circulating creatini... 2 | 31
increased leukocyte cell numbe... 2 | 37
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
edema 1 | 11
embryonic lethality prior to t... 1 | 187
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
polydactyly 1 | 22
respiratory system phenotype 1 | 2
small testis 1 | 37

Disease

ovarian cancer 91 | 8,484
lung cancer 69 | 4,466
osteosarcoma 68 | 7,933
psoriasis 61 | 6,685
glioblastoma 52 | 5,572
Cancer 44 | 2,346
lung carcinoma 39 | 2,844
medulloblastoma, large-cell 38 | 6,234
Multiple myeloma 35 | 1,327
interstitial cystitis 33 | 2,299
invasive ductal carcinoma 33 | 2,950
atypical teratoid / rhabdoid tumor 30 | 4,369
diabetes mellitus 29 | 1,663
cutaneous lupus erythematosus 28 | 1,056
Breast cancer 27 | 3,094
malignant mesothelioma 27 | 3,162
subependymal giant cell astrocytoma 27 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
non-small cell lung cancer 26 | 2,798
primary Sjogren syndrome 26 | 789
Rheumatoid Arthritis 25 | 1,160
dermatomyositis 25 | 933
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
ulcerative colitis 25 | 2,087
tuberculosis 24 | 1,557
Waldenstrons macroglobulinemia 23 | 765
pilocytic astrocytoma 23 | 3,086
juvenile dermatomyositis 22 | 1,189
oligodendroglioma 22 | 2,849
pancreatic cancer 21 | 2,300
Carcinoma 19 | 2,147
ependymoma 19 | 2,514
astrocytic glioma 18 | 2,241
astrocytoma 18 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
HIV Infections 17 | 100
medulloblastoma 17 | 1,524
primitive neuroectodermal tumor 17 | 3,031
Pick disease 16 | 1,893
pediatric high grade glioma 16 | 2,712
sarcoidosis 16 | 358
adult high grade glioma 15 | 2,148
breast carcinoma 15 | 1,614
Asthma 14 | 349
IGA Glomerulonephritis 14 | 454
cystic fibrosis 14 | 1,665
lung adenocarcinoma 14 | 2,713
primary pancreatic ductal adenocarcinoma 14 | 1,271
Hypersensitivity reaction type II disease 13 | 235
Multiple Sclerosis 13 | 498
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
active Crohn's disease 11 | 918
non primary Sjogren syndrome sicca 11 | 840
Duchenne muscular dystrophy 10 | 602
acute myeloid leukemia 10 | 780
group 3 medulloblastoma 10 | 2,254
pituitary cancer 10 | 1,972
posterior fossa group A ependymoma 10 | 1,511
Mammary Neoplasms 9 | 410
Narcolepsy 9 | 58
Type 1 diabetes mellitus 9 | 101
esophageal adenocarcinoma 9 | 737
group 4 medulloblastoma 9 | 1,875
pancreatic carcinoma 9 | 567
Diabetes Mellitus, Insulin-Dependent 8 | 76
Renal Cell Carcinoma 8 | 199
Schizophrenia 8 | 501
adrenocortical carcinoma 8 | 1,427
colon cancer 8 | 1,475
ductal carcinoma in situ 8 | 1,745
gastric carcinoma 8 | 832
Adult T-Cell Lymphoma/Leukemia 7 | 30
Arthritis 7 | 248
Crohn's disease 7 | 304
Lung Neoplasms 7 | 171
Mantle cell lymphoma 7 | 18
Proteinuria 7 | 63
Severe Combined Immunodeficiency 7 | 46
acute quadriplegic myopathy 7 | 1,157
hepatocellular carcinoma 7 | 532
tuberculosis and treatment for 6 months 7 | 686
Alzheimer's disease 6 | 644
Atopic dermatitis 6 | 944
Autistic Disorder 6 | 320
Celiac disease 6 | 112
Dermatitis 6 | 107
Diffuse large B-cell lymphoma 6 | 41
Down syndrome 6 | 548
Hypersensitivity 6 | 63
Juvenile rheumatoid arthritis 6 | 104
Liver disease 6 | 219
Prostatic Neoplasms 6 | 471
active ulcerative colitis 6 | 477
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
Inflammatory bowel disease 5 | 142
Lung disease 5 | 132
Parkinson's disease 5 | 364
Vasculitis 5 | 64
nasopharyngeal carcinoma 5 | 1,056
progressive supranuclear palsy 5 | 674

Tissue

Blood and immune system 144 | 17,995
Digestive Tract 144 | 18,473
Endocrine System 144 | 18,512
Female tissues 144 | 18,647
Liver and Pancreas 144 | 18,136
Male tissues 144 | 17,969
Nervous System 144 | 18,561
Urinary Tract 144 | 18,444
Respiratory system 143 | 17,484
Cardiovascular System 142 | 17,958
Skin and soft tissues 137 | 18,115

Target Family

Non-IDG 77 | 11,971
Enzyme 56 | 4,146
Kinase 23 | 634
Transcription Factor 4 | 1,400
Ion Channel 1 | 341

GO Process

T cell receptor signaling path... 161 | 161
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

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