Development Level

Tbio 46 | 10,625
Tchem 24 | 1,890
Tclin 16 | 602
Tdark 6 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 2 | 633
small superior vagus ganglion 2 | 20
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased lean body mass 1 | 195
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased cardiac stroke volum... 1 | 1
increased circulating LDL chol... 1 | 15
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
prenatal lethality prior to he... 1 | 64

Disease

Cancer 38 | 2,346
osteosarcoma 36 | 7,933
ovarian cancer 36 | 8,484
lung carcinoma 33 | 2,844
psoriasis 33 | 6,685
interstitial cystitis 29 | 2,299
lung cancer 28 | 4,466
Rheumatoid Arthritis 27 | 1,160
diabetes mellitus 24 | 1,663
invasive ductal carcinoma 23 | 2,950
glioblastoma 21 | 5,572
medulloblastoma, large-cell 21 | 6,234
non-small cell lung cancer 18 | 2,798
cutaneous lupus erythematosus 17 | 1,056
primary Sjogren syndrome 17 | 789
tuberculosis 17 | 1,557
Hypersensitivity reaction type II disease 16 | 235
Multiple Sclerosis 16 | 498
ulcerative colitis 16 | 2,087
Breast cancer 15 | 3,094
breast carcinoma 15 | 1,614
malignant mesothelioma 15 | 3,162
pilocytic astrocytoma 15 | 3,086
subependymal giant cell astrocytoma 15 | 2,287
cystic fibrosis 14 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
juvenile dermatomyositis 13 | 1,189
adult high grade glioma 12 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
oligodendroglioma 12 | 2,849
pancreatic cancer 12 | 2,300
Asthma 11 | 349
Celiac disease 11 | 112
group 4 medulloblastoma 11 | 1,875
lung adenocarcinoma 11 | 2,713
sarcoidosis 11 | 358
Carcinoma 10 | 2,147
atypical teratoid / rhabdoid tumor 10 | 4,369
dermatomyositis 10 | 933
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
pediatric high grade glioma 9 | 2,712
Hypersensitivity 8 | 63
Narcolepsy 8 | 58
Pick disease 8 | 1,893
Waldenstrons macroglobulinemia 8 | 765
active Crohn's disease 8 | 918
astrocytic glioma 8 | 2,241
astrocytoma 8 | 1,493
medulloblastoma 8 | 1,524
primary pancreatic ductal adenocarcinoma 8 | 1,271
Hepatitis B 7 | 103
Kidney disease 7 | 396
Type 1 diabetes mellitus 7 | 101
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primitive neuroectodermal tumor 7 | 3,031
Adult T-Cell Lymphoma/Leukemia 6 | 30
Atopic dermatitis 6 | 944
Blastic phase chronic myeloid leukemia 6 | 58
Chronic Lymphocytic Leukemia 6 | 242
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Down syndrome 6 | 548
Duchenne muscular dystrophy 6 | 602
IGA Glomerulonephritis 6 | 454
Juvenile rheumatoid arthritis 6 | 104
Liver disease 6 | 219
Lupus Erythematosus, Systemic 6 | 73
Multiple myeloma 6 | 1,327
Renal Cell Carcinoma 6 | 199
Vasculitis 6 | 64
colon cancer 6 | 1,475
ependymoma 6 | 2,514
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 832
group 3 medulloblastoma 6 | 2,254
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
non-small cell lung carcinoma 6 | 413
pancreatic carcinoma 6 | 567
systemic lupus erythematosus 6 | 156
Addison's disease 5 | 29
Allergic hypersensitivity disease 5 | 123
Autoimmune thyroiditis 5 | 24
Chronic phase chronic myeloid leukemia 5 | 45
Dermatitis 5 | 107
Diabetes Mellitus, Insulin-Dependent 5 | 76
Graves' disease 5 | 25
Mammary Neoplasms 5 | 410
Obesity 5 | 616
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Proteinuria 5 | 63
Renal transplant rejection 5 | 13
Schizophrenia 5 | 501
Systemic scleroderma 5 | 66
nasopharyngeal carcinoma 5 | 1,056
Urticaria 4 | 53
fibroadenoma 4 | 557
nephrosclerosis 4 | 329

Tissue

Blood and immune system 74 | 17,995
Digestive Tract 74 | 18,473
Endocrine System 74 | 18,512
Female tissues 74 | 18,647
Liver and Pancreas 74 | 18,136
Male tissues 74 | 17,969
Nervous System 74 | 18,561
Respiratory system 74 | 17,484
Urinary Tract 74 | 18,444
Cardiovascular System 73 | 17,958
Skin and soft tissues 69 | 18,115

Target Family

Non-IDG 70 | 11,971
Kinase 16 | 634
Enzyme 6 | 4,146

GO Process

T cell costimulation 92 | 92
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

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