Development Level

Tbio 49 | 11,651
Tchem 18 | 1,388
Tclin 16 | 612
Tdark 6 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased vertical activity 2 | 208
increased blood urea nitrogen ... 2 | 48
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Cancer 39 | 2,499
Rheumatoid arthritis 37 | 1,191
ovarian cancer 35 | 8,520
osteosarcoma 34 | 7,950
lung carcinoma 33 | 2,843
psoriasis 33 | 6,694
Carcinoma 32 | 11,493
lung cancer 30 | 4,740
interstitial cystitis 29 | 2,312
diabetes mellitus 26 | 1,728
glioblastoma 25 | 5,792
invasive ductal carcinoma 23 | 2,951
medulloblastoma, large-cell 22 | 6,241
sarcoidosis 21 | 370
tuberculosis 20 | 2,010
Hypersensitivity reaction type II disease 19 | 253
Systemic lupus erythematosus 19 | 194
adult high grade glioma 18 | 3,801
breast carcinoma 18 | 1,638
non-small cell lung cancer 18 | 2,890
Breast cancer 17 | 3,578
Multiple Sclerosis 17 | 540
Narcolepsy 17 | 72
cutaneous lupus erythematosus 17 | 1,057
Astrocytoma, Pilocytic 16 | 3,081
Berylliosis 16 | 28
Multiple Sclerosis, Susceptibility to 15 | 15
cystic fibrosis 15 | 1,696
primary Sjogren syndrome 15 | 735
subependymal giant cell astrocytoma 15 | 2,287
ulcerative colitis 15 | 1,819
Diffuse cutaneous systemic sclerosis 14 | 17
Narcolepsy-cataplexy 14 | 21
Schizophrenia 14 | 1,160
follicular lymphoma 14 | 20
limited scleroderma 14 | 19
malignant mesothelioma 14 | 3,232
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
ependymoma 13 | 4,679
pancreatic cancer 13 | 2,398
Autosomal recessive predisposition 12 | 1,442
Celiac disease 12 | 116
atypical teratoid / rhabdoid tumor 12 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
juvenile dermatomyositis 12 | 1,187
group 3 medulloblastoma 11 | 4,104
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung adenocarcinoma 11 | 2,716
oligodendroglioma 11 | 2,850
Arthritis, Rheumatoid 10 | 174
Asthma 10 | 385
Autoimmune Diseases 10 | 67
Hepatitis B 10 | 108
Immunologic Deficiency Syndromes 10 | 113
Kidney cancer 10 | 2,613
Juvenile rheumatoid arthritis 9 | 111
Proteinuria 9 | 144
ductal carcinoma in situ 9 | 1,745
Hypersensitivity 8 | 63
Waldenstrons macroglobulinemia 8 | 765
active Crohn's disease 8 | 922
astrocytoma 8 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primitive neuroectodermal tumor 8 | 3,035
Atopic dermatitis 7 | 952
Kidney disease 7 | 430
Liver Cirrhosis, Experimental 7 | 769
Liver disease 7 | 237
Melanoma 7 | 711
Pick disease 7 | 1,894
Recurrent respiratory infections 7 | 141
Renal Cell Carcinoma 7 | 214
Splenomegaly 7 | 190
Type 1 diabetes mellitus 7 | 109
Vasculitis 7 | 80
astrocytic glioma 7 | 2,597
dermatomyositis 7 | 966
Adult T-Cell Lymphoma/Leukemia 6 | 30
Arthritis 6 | 290
Breast Neoplasms 6 | 445
Crohn's disease 6 | 321
Diarrhea 6 | 253
Down syndrome 6 | 499
Duchenne muscular dystrophy 6 | 601
Hepatomegaly 6 | 285
Infantile onset 6 | 238
Intellectual disability 6 | 1,016
Leukemia-Lymphoma, Adult T-Cell 6 | 30
Mammary Neoplasms 6 | 425
Multiple myeloma 6 | 1,332
active ulcerative colitis 6 | 764
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 807
head and neck cancer and chronic obstructive pulmonary disease 6 | 239
pancreatic carcinoma 6 | 562
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Blood and immune system 66 | 16,909
Liver and Pancreas 66 | 16,750
Digestive Tract 65 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Male tissues 64 | 17,142
Nervous System 62 | 16,725
Cardiovascular System 61 | 15,192

Target Family

Non-IDG 68 | 12,091
Kinase 15 | 634
Enzyme 6 | 4,145

GO Process

T cell costimulation 89 | 89
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
C-C motif chemokine 19 CCL19 Tbio Non-IDG -2.45693 253.7 310
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Programmed cell death 1 ligand 1 CD274 Tclin Non-IDG -3.53386 3285.3 993
Inducible T-cell costimulator ICOS Tbio Non-IDG -1.63332 39.2 649
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Ephrin-B2 EFNB2 Tbio Non-IDG -2.45068 288.9 381
Tumor necrosis factor ligand superfamily member 14 TNFSF14 Tbio Non-IDG -1.82288 61.4 389
T-cell receptor alpha chain V region HPB-MLT N/A Tdark Non-IDG 0.00000 0