Development Level

Tbio 40 | 11,445
Tchem 9 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
abnormal snout morphology 2 | 23
decreased prepulse inhibition 2 | 82
increased blood urea nitrogen ... 2 | 48
mammalian phenotype 2 | 17
abnormal coat-hair pigmentatio... 1 | 64
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
absent vibrissae 1 | 12
curly tail 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
kinked tail 1 | 2
limb grasping 1 | 41
tremors 1 | 39

Disease

Carcinoma 40 | 11,493
osteosarcoma 36 | 7,950
ovarian cancer 31 | 8,520
atypical teratoid / rhabdoid tumor 27 | 5,112
glioblastoma 26 | 5,792
psoriasis 26 | 6,694
medulloblastoma, large-cell 25 | 6,241
ependymoma 24 | 4,679
adult high grade glioma 20 | 3,801
invasive ductal carcinoma 19 | 2,951
oligodendroglioma 19 | 2,850
Cancer 18 | 2,499
lung cancer 18 | 4,740
Astrocytoma, Pilocytic 16 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
pancreatic cancer 16 | 2,398
Breast cancer 15 | 3,578
astrocytic glioma 15 | 2,597
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
non-small cell lung cancer 15 | 2,890
primitive neuroectodermal tumor 15 | 3,035
Kidney cancer 14 | 2,613
malignant mesothelioma 14 | 3,232
pituitary cancer 14 | 1,972
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
cystic fibrosis 11 | 1,696
group 4 medulloblastoma 11 | 1,855
lung carcinoma 11 | 2,843
spina bifida 11 | 1,074
subependymal giant cell astrocytoma 11 | 2,287
juvenile dermatomyositis 10 | 1,187
lung adenocarcinoma 10 | 2,716
Schizophrenia 9 | 1,160
acute quadriplegic myopathy 9 | 1,158
interstitial cystitis 9 | 2,312
primary pancreatic ductal adenocarcinoma 8 | 1,109
ulcerative colitis 8 | 1,819
Pick disease 7 | 1,894
Rheumatoid arthritis 7 | 1,191
colon cancer 7 | 1,478
tuberculosis 7 | 2,010
Hypertension 6 | 396
diabetes mellitus 6 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Alzheimer's disease 5 | 658
Attention deficit hyperactivity disorder 5 | 278
Intellectual disability 5 | 1,016
Proteinuria 5 | 144
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
astrocytoma 5 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
dermatomyositis 5 | 966
pancreatic carcinoma 5 | 562
Autosomal recessive predisposition 4 | 1,442
Cerebral Ischemia 4 | 37
Crohn's disease 4 | 321
Depressive disorder 4 | 409
Down syndrome 4 | 499
Epilepsy 4 | 792
Heart disease 4 | 306
Liver cancer 4 | 604
Seizures 4 | 596
Small head 4 | 374
aldosterone-producing adenoma 4 | 665
fibroadenoma 4 | 559
gastric cancer 4 | 459
gastric carcinoma 4 | 807
Amyotrophic lateral sclerosis 3 | 451
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Cerebrovascular disease 3 | 238
Dull intelligence 3 | 645
Heart failure 3 | 162
Hypertensive disease 3 | 292
Impotence 3 | 42
Kidney disease 3 | 430
Low intelligence 3 | 645
Melanoma 3 | 711
Mental Depression 3 | 333
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Obesity 3 | 678
Ocular hypertension 3 | 42
Osteoporosis 3 | 363
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Psychotic Disorders 3 | 151
Skin cancer 3 | 469
Type 2 diabetes mellitus 3 | 272
esophageal adenocarcinoma 3 | 737
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
chronic rhinosinusitis 2 | 512
hepatocellular carcinoma 2 | 547

Tissue

Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Male tissues 57 | 17,142
Skin and soft tissues 57 | 17,230
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Cardiovascular System 55 | 15,192
Urinary Tract 55 | 16,678
Blood and immune system 54 | 16,909
Nervous System 54 | 16,725
Respiratory system 54 | 16,393

Target Family

Non-IDG 25 | 12,091
Enzyme 15 | 4,145
Kinase 12 | 634
GPCR 4 | 408
Transcription Factor 1 | 1,400

GO Process

Rho protein signal transductio... 57 | 57
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adhesion G-protein coupled receptor G1 ADGRG1 Tbio GPCR -1.94601 100.6 182
Rhotekin RTKN Tbio Non-IDG -1.49615 24.3 137
Rho GTPase-activating protein 6 ARHGAP6 Tbio Enzyme -0.85601 8.06 45
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.82623 8.55 107
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Unconventional myosin-IXb MYO9B Tbio Non-IDG -1.68591 55.7 79
Cdc42 effector protein 1 CDC42EP1 Tbio Non-IDG -0.84557 7.77 106
Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 Tbio GPCR -1.47924 34.4 115
Rho GTPase-activating protein 4 ARHGAP4 Tbio Enzyme -1.07219 11.8 83