Development Level

Tbio 42 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal locomotor behavior 1 | 24
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased cornea thickness 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112

Disease

ovarian cancer 32 | 8,520
Carcinoma 25 | 11,493
osteosarcoma 24 | 7,950
group 3 medulloblastoma 20 | 4,104
Multiple myeloma 16 | 1,332
acute quadriplegic myopathy 14 | 1,158
ependymoma 14 | 4,679
medulloblastoma, large-cell 14 | 6,241
psoriasis 14 | 6,694
glioblastoma 11 | 5,792
Waldenstrons macroglobulinemia 10 | 765
atypical teratoid / rhabdoid tumor 10 | 5,112
lung cancer 10 | 4,740
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
Pick disease 9 | 1,894
dermatomyositis 9 | 966
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
oligodendroglioma 8 | 2,850
adult high grade glioma 7 | 3,801
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
lung adenocarcinoma 7 | 2,716
primitive neuroectodermal tumor 7 | 3,035
Amyotrophic lateral sclerosis 6 | 451
malignant mesothelioma 6 | 3,232
progressive supranuclear palsy 6 | 676
subependymal giant cell astrocytoma 6 | 2,287
Cancer 5 | 2,499
acute myeloid leukemia 5 | 783
breast carcinoma 5 | 1,638
juvenile dermatomyositis 5 | 1,187
Hereditary spherocytosis type 5 4 | 12
Intellectual disability 4 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
Breast Neoplasms 3 | 445
Frontotemporal dementia 3 | 51
Mammary Neoplasms 3 | 425
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Rheumatoid arthritis 3 | 1,191
Skeletal muscle atrophy 3 | 139
Subcutaneous panniculitis-like T-cell lymphoma 3 | 16
atypical teratoid/rhabdoid tumor 3 | 357
cystic fibrosis 3 | 1,696
muscle degeneration 3 | 139
non-small cell lung cancer 3 | 2,890
Animal Mammary Neoplasms 2 | 136
Anxiety 2 | 136
Anxiety disease 2 | 113
Astrocytoma, Pilocytic 2 | 3,081
Cockayne syndrome 2 | 60
Congenital myasthenic syndrome 5 2 | 11
Dental pulp necrosis 2 | 10
Depressive disorder 2 | 409
Dyspnea 2 | 76
Fatigable weakness of respiratory muscles 2 | 28
Fatigable weakness of swallowing muscles 2 | 28
Fatigue 2 | 182
Generalized muscle weakness 2 | 57
INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA 2 | 3
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mixed connective tissue disease 2 | 16
Mood swings 2 | 77
Muscle Cramp 2 | 55
Muscle Spasticity 2 | 195
Muscle biopsy shows dystrophic changes 2 | 39
Muscle hypotonia 2 | 571
Muscular dystrophy 2 | 75
Myopathy 2 | 185
Nerve Degeneration 2 | 121
Neuro-degenerative disease 2 | 43
Neurodegenerative Disorders 2 | 79
Neurodegenerative disease 2 | 414
Pain 2 | 103
Paralysed 2 | 42
Polycystic ovary syndrome 2 | 360
Respiratory Failure 2 | 104
Schizophrenia 2 | 1,160
Spinal muscular atrophy 2 | 34
Xeroderma pigmentosum group B 2 | 20
Xerostomia 2 | 42
colon cancer 2 | 1,478
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
primary Sjogren syndrome 2 | 735
relapsing-remitting multiple sclerosis 2 | 18
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 43 | 16,909
Cardiovascular System 43 | 15,192
Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678

Target Family

Non-IDG 25 | 12,091
Enzyme 18 | 4,145

GO Process

RNA metabolic process 43 | 43
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
N6-adenosine-methyltransferase catalytic subunit METTL3 Tbio Enzyme -1.76174 60.5 94
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Heterogeneous nuclear ribonucleoprotein L HNRNPL Tbio Non-IDG -2.53786 319.0 271
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
Polypyrimidine tract-binding protein 1 PTBP1 Tbio Non-IDG -2.65368 405.7 321
5'-3' exoribonuclease 2 XRN2 Tbio Enzyme -1.52792 31.8 121