Development Level

Tbio 131 | 10,625
Tchem 61 | 1,890
Tclin 40 | 602
Tdark 5 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 633
decreased body weight 6 | 174
decreased bone mineral content 6 | 157
abnormal bone structure 5 | 131
decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
decreased circulating alanine ... 3 | 53
decreased kidney weight 3 | 7
decreased lean body mass 3 | 195
decreased lumbar vertebrae num... 3 | 62
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
abnormal QRS complex 2 | 25
abnormal behavior 2 | 226
abnormal coat-hair pigmentatio... 2 | 54
abnormal retina morphology 2 | 100
cataract 2 | 26
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased spleen weight 2 | 13
impaired pupillary reflex 2 | 14
impaired righting response 2 | 19
increased lean body mass 2 | 107
increased startle reflex 2 | 38
male infertility 2 | 62
short tibia 2 | 82
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cleft palate 1 | 6
corneal opacity 1 | 25
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
mydriasis 1 | 9
narrow eye opening 1 | 15
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
small testis 1 | 37
sparse hair 1 | 6
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 133 | 8,491
osteosarcoma 118 | 7,933
glioblastoma 107 | 5,572
psoriasis 101 | 6,685
medulloblastoma, large-cell 100 | 6,234
Cancer 97 | 2,346
lung cancer 96 | 4,473
atypical teratoid / rhabdoid tumor 72 | 4,369
pilocytic astrocytoma 67 | 3,086
malignant mesothelioma 65 | 3,163
oligodendroglioma 57 | 2,849
ependymoma 56 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
Breast cancer 55 | 3,098
lung carcinoma 52 | 2,844
pediatric high grade glioma 52 | 2,712
invasive ductal carcinoma 50 | 2,950
Carcinoma 47 | 2,147
lung adenocarcinoma 45 | 2,714
subependymal giant cell astrocytoma 45 | 2,287
Multiple myeloma 44 | 1,327
interstitial cystitis 44 | 2,299
primitive neuroectodermal tumor 44 | 3,031
astrocytic glioma 43 | 2,241
non-small cell lung cancer 43 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
ulcerative colitis 41 | 2,087
pancreatic cancer 39 | 2,300
diabetes mellitus 38 | 1,663
medulloblastoma 38 | 1,524
Pick disease 37 | 1,893
cystic fibrosis 37 | 1,670
astrocytoma 36 | 1,493
group 3 medulloblastoma 33 | 2,254
tuberculosis 32 | 1,563
pituitary cancer 30 | 1,972
Rheumatoid Arthritis 27 | 1,170
colon cancer 27 | 1,475
adult high grade glioma 26 | 2,148
breast carcinoma 26 | 1,614
ductal carcinoma in situ 26 | 1,745
group 4 medulloblastoma 25 | 1,875
primary pancreatic ductal adenocarcinoma 25 | 1,271
Alzheimer's disease 24 | 644
juvenile dermatomyositis 24 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
Mammary Neoplasms 22 | 410
Parkinson's disease 22 | 364
cutaneous lupus erythematosus 22 | 1,056
dermatomyositis 22 | 966
posterior fossa group A ependymoma 22 | 1,511
Schizophrenia 20 | 503
posterior fossa group B ependymoma 19 | 1,530
Asthma 18 | 349
HIV Infections 18 | 99
Heart disease 18 | 279
Lung Neoplasms 18 | 171
Prostatic Neoplasms 18 | 471
spina bifida 18 | 1,064
Intellectual disability 17 | 573
Multiple Sclerosis 17 | 498
Obesity 17 | 616
Waldenstrons macroglobulinemia 17 | 764
atypical teratoid/rhabdoid tumor 17 | 1,095
Hypersensitivity reaction type II disease 16 | 235
Lung disease 16 | 136
adrenocortical carcinoma 16 | 1,427
gastric carcinoma 16 | 832
non-small cell lung carcinoma 16 | 413
primary Sjogren syndrome 16 | 788
Arthritis 15 | 248
Atherosclerosis 15 | 275
Melanoma 15 | 261
Vascular disease 15 | 281
esophageal adenocarcinoma 15 | 737
non primary Sjogren syndrome sicca 15 | 840
Anemia 14 | 252
Cleft palate 14 | 125
Diarrhea 14 | 155
Eosinophilia 14 | 65
Kidney disease 14 | 397
Liver carcinoma 14 | 217
Myocardial Ischemia 14 | 169
Pulmonary Fibrosis 14 | 66
Renal Cell Carcinoma 14 | 199
Stomach Neoplasms 14 | 282
hepatocellular carcinoma 14 | 550
Amyotrophic Lateral Sclerosis 13 | 432
Down syndrome 13 | 548
Neoplasm Metastasis 13 | 138
Osteoporosis 13 | 259
Peripheral Neuropathy 13 | 303
acute myeloid leukemia 13 | 785
acute quadriplegic myopathy 13 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
sarcoidosis 13 | 368
tuberculosis and treatment for 6 months 13 | 686
Crohn's disease 12 | 304
sonic hedgehog group medulloblastoma 12 | 1,482

Tissue

Endocrine System 235 | 18,511
Female tissues 235 | 18,646
Nervous System 235 | 18,560
Digestive Tract 234 | 18,472
Urinary Tract 234 | 18,443
Blood and immune system 233 | 17,994
Liver and Pancreas 233 | 18,135
Cardiovascular System 231 | 17,957
Male tissues 230 | 17,968
Skin and soft tissues 230 | 18,114
Respiratory system 224 | 17,483

Target Family

Non-IDG 123 | 11,969
Enzyme 61 | 4,146
Kinase 40 | 634
Transcription Factor 7 | 1,400
Ion Channel 5 | 341
GPCR 1 | 408

GO Process

MAPK cascade 237 | 237
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epidermal growth factor receptor EGFR Tclin Kinase -3.98983 9318.1 4989