Development Level

Tbio 130 | 11,178
Tchem 65 | 1,885
Tclin 42 | 612
Tdark 5 | 6,569

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 979
decreased body weight 7 | 161
abnormal bone structure 6 | 187
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
decreased circulating choleste... 5 | 93
embryonic lethality prior to t... 5 | 278
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
male infertility 4 | 123
short tibia 4 | 97
cataract 3 | 92
decreased circulating LDL chol... 3 | 38
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
female infertility 3 | 60
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal lens morphology 2 | 81
abnormal optic disc morphology 2 | 10
abnormal retina morphology 2 | 71
abnormal retinal vasculature m... 2 | 27
decreased circulating alanine ... 2 | 47
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lactate dehydrogenas... 2 | 16
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 145 | 11,192
osteosarcoma 118 | 7,766
ovarian cancer 118 | 8,297
glioblastoma 101 | 5,635
medulloblastoma, large-cell 96 | 6,086
Cancer 94 | 2,388
lung cancer 93 | 4,607
psoriasis 89 | 6,514
atypical teratoid / rhabdoid tumor 82 | 4,971
ependymoma 77 | 4,559
malignant mesothelioma 72 | 3,135
Breast cancer 64 | 3,469
group 3 medulloblastoma 61 | 4,002
Astrocytoma, Pilocytic 59 | 3,006
adult high grade glioma 57 | 3,701
Schizophrenia 56 | 1,136
oligodendroglioma 55 | 2,768
Kidney cancer 52 | 2,548
astrocytic glioma 51 | 2,530
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,204
invasive ductal carcinoma 49 | 2,867
lung carcinoma 48 | 2,755
subependymal giant cell astrocytoma 44 | 2,230
interstitial cystitis 43 | 2,237
lung adenocarcinoma 43 | 2,627
non-small cell lung cancer 42 | 2,799
primitive neuroectodermal tumor 42 | 2,957
tuberculosis 42 | 1,963
Pick disease 39 | 1,856
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,872
pancreatic cancer 38 | 2,322
ulcerative colitis 38 | 1,765
cystic fibrosis 35 | 1,629
Bipolar Disorder 34 | 646
Multiple myeloma 34 | 1,296
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,902
diabetes mellitus 32 | 1,683
group 4 medulloblastoma 32 | 1,806
Rheumatoid arthritis 31 | 1,156
pituitary cancer 28 | 1,915
astrocytoma 27 | 1,113
breast carcinoma 26 | 1,589
Epilepsy 25 | 775
Liver Cirrhosis, Experimental 25 | 733
Melanoma 25 | 689
colon cancer 25 | 1,428
Autosomal recessive predisposition 24 | 1,407
Alzheimer's disease 23 | 640
Depressive disorder 23 | 401
ductal carcinoma in situ 23 | 1,686
Lung Neoplasms 21 | 217
Parkinson's disease 21 | 378
cutaneous lupus erythematosus 21 | 1,016
juvenile dermatomyositis 21 | 1,147
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,911
Breast Neoplasms 20 | 423
Intellectual disability 20 | 998
Mammary Neoplasms 20 | 403
Seizures 20 | 584
primary pancreatic ductal adenocarcinoma 20 | 1,071
Downward slant of palpebral fissure 19 | 158
Major Depressive Disorder 19 | 293
Prostatic Neoplasms 19 | 472
spina bifida 19 | 1,053
Carcinoma, Hepatocellular 18 | 217
Cryptorchidism 18 | 287
Liver carcinoma 18 | 229
Skin cancer 18 | 451
Stomach Neoplasms 18 | 287
Unipolar Depression 18 | 244
dermatomyositis 18 | 941
Anemia 17 | 353
Asthma 17 | 370
Cognitive delay 17 | 596
Global developmental delay 17 | 596
Hypersensitivity reaction type II disease 17 | 245
Lung disease 17 | 135
Mental Depression 17 | 325
Mental and motor retardation 17 | 596
Multiple Sclerosis 17 | 527
Neoplasm Invasiveness 17 | 151
Orbital separation excessive 17 | 240
adrenocortical carcinoma 17 | 1,385
Blepharoptosis 16 | 229
Heart disease 16 | 288
Kidney disease 16 | 411
Neoplasm Metastasis 16 | 160
Short stature 16 | 514
Vascular disease 16 | 294
Cleft Palate 15 | 265
Dull intelligence 15 | 634
Low intelligence 15 | 634
Mental Retardation 15 | 634
Mental deficiency 15 | 634
Muscle hypotonia 15 | 562
Obesity 15 | 655
Osteoporosis 15 | 348
Poor school performance 15 | 634
esophageal adenocarcinoma 15 | 696
gastric carcinoma 15 | 781

Tissue

Endocrine System 239 | 18,159
Blood and immune system 234 | 16,909
Digestive Tract 234 | 17,369
Female tissues 233 | 17,400
Skin and soft tissues 233 | 17,230
Liver and Pancreas 232 | 16,750
Male tissues 232 | 17,142
Urinary Tract 231 | 16,678
Nervous System 230 | 16,725
Respiratory system 227 | 16,393
Cardiovascular System 218 | 15,192

Target Family

Non-IDG 125 | 12,091
Enzyme 62 | 4,145
Kinase 43 | 634
Transcription Factor 6 | 1,400
Ion Channel 5 | 344
GPCR 1 | 408

GO Process

MAPK cascade 242 | 242
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859
Tumor necrosis factor TNF Tclin Non-IDG -4.71806 50345.6 2958
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254
Insulin INS Tbio Non-IDG -5.17849 146933.7 2197
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982