Development Level

Tbio 37 | 11,445
Tchem 18 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
absent vibrissae 2 | 12
increased eosinophil cell numb... 2 | 11
increased leukocyte cell numbe... 2 | 47
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged uterus 1 | 11
increased CD4-positive, alpha ... 1 | 4
increased basophil cell number 1 | 7
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 40 | 11,493
ovarian cancer 29 | 8,520
Cancer 27 | 2,499
osteosarcoma 27 | 7,950
lung cancer 24 | 4,740
psoriasis 23 | 6,694
glioblastoma 21 | 5,792
medulloblastoma, large-cell 20 | 6,241
tuberculosis 17 | 2,010
lung carcinoma 16 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
interstitial cystitis 12 | 2,312
Kidney cancer 11 | 2,613
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
adult high grade glioma 10 | 3,801
malignant mesothelioma 10 | 3,232
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Astrocytoma, Pilocytic 9 | 3,081
Rheumatoid arthritis 9 | 1,191
acute myeloid leukemia 9 | 783
cystic fibrosis 9 | 1,696
dermatomyositis 9 | 966
diabetes mellitus 9 | 1,728
juvenile dermatomyositis 9 | 1,187
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
Arthritis 8 | 290
astrocytic glioma 8 | 2,597
group 4 medulloblastoma 8 | 1,855
oligodendroglioma 8 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Asthma 7 | 385
Fever 7 | 138
Inflammatory bowel disease 7 | 151
Schizophrenia 7 | 1,160
group 3 medulloblastoma 7 | 4,104
Anemia 6 | 365
Atopic dermatitis 6 | 952
Breast cancer 6 | 3,578
Epilepsy 6 | 792
Fatigue 6 | 182
Hypersensitivity reaction type II disease 6 | 253
Immunologic Deficiency Syndromes 6 | 113
Lung disease 6 | 142
Pneumonia 6 | 174
astrocytoma 6 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Alzheimer's disease 5 | 658
Arthritis, Rheumatoid 5 | 174
Brain Injuries 5 | 65
Breast Neoplasms 5 | 445
Diarrhea 5 | 253
Heat Stroke 5 | 13
Hypertension 5 | 396
Kidney disease 5 | 430
Liver Cirrhosis, Experimental 5 | 769
Liver disease 5 | 237
Mammary Neoplasms 5 | 425
Multiple myeloma 5 | 1,332
Seizures 5 | 596
aldosterone-producing adenoma 5 | 665
cutaneous lupus erythematosus 5 | 1,057
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
mucosa-associated lymphoid tissue lymphoma 5 | 484
non primary Sjogren syndrome sicca 5 | 891
posterior fossa group A ependymoma 5 | 468
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Brain Ischemia 4 | 110
Cleft Palate 4 | 271
Colorectal Neoplasms 4 | 243
Constipation 4 | 181
Crohn's disease 4 | 321
Depressive disorder 4 | 409
Dermatitis 4 | 157
Dyschezia 4 | 135
Failure to gain weight 4 | 365
Fatty Liver 4 | 70
Glaucoma 4 | 239
Heart disease 4 | 306
Infantile onset 4 | 238
Influenza 4 | 142
Lung Neoplasms 4 | 232
Nausea and vomiting 4 | 97
Obesity 4 | 678
Pediatric failure to thrive 4 | 365
Short stature 4 | 531
Splenomegaly 4 | 190
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
hepatocellular carcinoma 4 | 547
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
spina bifida 4 | 1,074

Tissue

Blood and immune system 63 | 16,909
Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 63 | 17,400
Male tissues 63 | 17,142
Respiratory system 63 | 16,393
Skin and soft tissues 63 | 17,230
Urinary Tract 62 | 16,678
Liver and Pancreas 61 | 16,750
Cardiovascular System 60 | 15,192
Nervous System 59 | 16,725

Target Family

Non-IDG 33 | 12,091
Kinase 15 | 634
Enzyme 9 | 4,145
Transcription Factor 5 | 1,400
GPCR 1 | 408

GO Process

I-kappaB kinase-NF-kappaB sign... 63 | 63
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242
Lymphocyte antigen 96 LY96 Tchem Non-IDG -2.77678 541.2 369
TRAF-interacting protein with FHA domain-containing protein B TIFAB Tbio Non-IDG -0.55328 2.93 54
NLR family CARD domain-containing protein 3 NLRC3 Tbio Non-IDG 0.00000 29
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139