Development Level

Tbio 93 | 11,445
Tchem 32 | 1,598
Tclin 5 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 7 | 278
decreased bone mineral content 5 | 151
decreased total body fat amoun... 5 | 207
embryonic lethality prior to o... 5 | 239
preweaning lethality, incomple... 5 | 499
decreased body weight 4 | 161
decreased lean body mass 4 | 135
male infertility 4 | 123
abnormal behavior 3 | 298
abnormal cranium morphology 3 | 36
abnormal head morphology 3 | 10
decreased body length 3 | 101
decreased circulating choleste... 3 | 93
increased mean corpuscular vol... 3 | 92
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal retinal blood vessel ... 2 | 26
abnormal spleen morphology 2 | 55
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
hypoactivity 2 | 132
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal external male genital... 1 | 1
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 13
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hydroencephaly 1 | 14
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
small seminal vesicle 1 | 10
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

ovarian cancer 95 | 8,520
Carcinoma 88 | 11,493
osteosarcoma 74 | 7,950
medulloblastoma, large-cell 63 | 6,241
psoriasis 62 | 6,694
glioblastoma 61 | 5,792
atypical teratoid / rhabdoid tumor 59 | 5,112
group 3 medulloblastoma 57 | 4,104
lung cancer 56 | 4,740
primitive neuroectodermal tumor 51 | 3,035
Breast cancer 49 | 3,578
ependymoma 46 | 4,679
adult high grade glioma 44 | 3,801
Cancer 43 | 2,499
malignant mesothelioma 41 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
Kidney cancer 36 | 2,613
non-small cell lung cancer 35 | 2,890
colon cancer 32 | 1,478
oligodendroglioma 29 | 2,850
Astrocytoma, Pilocytic 25 | 3,081
astrocytic glioma 25 | 2,597
lung adenocarcinoma 24 | 2,716
Pick disease 23 | 1,894
adrenocortical carcinoma 23 | 1,428
breast carcinoma 23 | 1,638
Intellectual disability 21 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
invasive ductal carcinoma 21 | 2,951
nasopharyngeal carcinoma 21 | 1,058
pancreatic cancer 21 | 2,398
tuberculosis 20 | 2,010
Multiple myeloma 19 | 1,332
ductal carcinoma in situ 19 | 1,745
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Schizophrenia 16 | 1,160
diabetes mellitus 16 | 1,728
subependymal giant cell astrocytoma 16 | 2,287
ulcerative colitis 16 | 1,819
Autosomal recessive predisposition 15 | 1,442
Microcephaly 15 | 166
Epilepsy 14 | 792
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Endometriosis 13 | 540
astrocytoma 13 | 1,146
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Short stature 12 | 531
Small head 12 | 374
Waldenstrons macroglobulinemia 12 | 765
pediatric high grade glioma 11 | 1,064
Atopic dermatitis 10 | 952
Glaucoma 10 | 239
acute myeloid leukemia 10 | 783
interstitial cystitis 10 | 2,312
juvenile dermatomyositis 10 | 1,187
pituitary cancer 10 | 1,972
Breast Neoplasms 9 | 445
Seizures 9 | 596
dermatomyositis 9 | 966
group 4 medulloblastoma 9 | 1,855
spina bifida 9 | 1,074
Downward slant of palpebral fissure 8 | 158
Joubert syndrome 8 | 66
Mammary Neoplasms 8 | 425
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 720
primary pancreatic ductal adenocarcinoma 8 | 1,109
Bipolar Disorder 7 | 666
Cataract 7 | 297
Dilated ventricles (finding) 7 | 121
Muscle hypotonia 7 | 571
Obesity 7 | 678
Pachygyria 7 | 41
cystic fibrosis 7 | 1,696
lung carcinoma 7 | 2,843
non primary Sjogren syndrome sicca 7 | 891
posterior fossa group B ependymoma 7 | 416
progressive supranuclear palsy 7 | 676
Agenesis of corpus callosum 6 | 83
Amyotrophic lateral sclerosis 6 | 451
Duchenne muscular dystrophy 6 | 601
Hypoplastic mandible condyle 6 | 275
Lens Opacities 6 | 231
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Micrognathism 6 | 275
Neuroblastoma 6 | 80
Neurodegenerative disease 6 | 414
Sloping forehead 6 | 46
active ulcerative colitis 6 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510

Tissue

Blood and immune system 134 | 16,909
Digestive Tract 134 | 17,369
Endocrine System 134 | 18,159
Female tissues 134 | 17,400
Liver and Pancreas 134 | 16,750
Male tissues 134 | 17,142
Nervous System 134 | 16,725
Respiratory system 134 | 16,393
Skin and soft tissues 134 | 17,230
Urinary Tract 134 | 16,678
Cardiovascular System 133 | 15,192

Target Family

Non-IDG 89 | 12,091
Enzyme 21 | 4,145
Kinase 20 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Transporter 1 | 473

GO Process

G2-M transition of mitotic cel... 134 | 134
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Cyclin-Y CCNY Tbio Non-IDG -1.48139 30.1 120
Serine/threonine-protein kinase BRSK2 BRSK2 Tchem Kinase -1.92813 85.3 187
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -2.03755 107.9 152