Development Level

Tdark 349 | 7,003
Tbio 174 | 10,625
Tchem 88 | 1,890
Tclin 55 | 602

Collection

Eligible non-olfactory GPCR Proteins 64 | 143

IMPC Term

preweaning lethality, complete... 9 | 633
decreased bone mineral content 7 | 157
decreased lean body mass 5 | 195
increased or absent threshold ... 5 | 128
abnormal retina morphology 4 | 100
decreased circulating insulin ... 4 | 75
decreased prepulse inhibition 4 | 52
enlarged heart 4 | 111
improved glucose tolerance 4 | 56
increased circulating HDL chol... 4 | 63
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal heart morphology 3 | 51
abnormal retinal pigmentation 3 | 61
abnormal seminal vesicle morph... 3 | 47
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased circulating alanine ... 3 | 53
decreased fasted circulating g... 3 | 49
increased grip strength 3 | 83
increased hemoglobin content 3 | 45
increased total body fat amoun... 3 | 57
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal epididymis morphology 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating glucose ... 2 | 121
decreased leukocyte cell numbe... 2 | 54
decreased monocyte cell number 2 | 28
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
female infertility 2 | 34
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased mean corpuscular vol... 2 | 91
abnormal embryo size 1 | 112
abnormal kidney morphology 1 | 30
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 11
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased kidney weight 1 | 7
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased red blood cell distr... 1 | 21
oligodactyly 1 | 14
short snout 1 | 4
short tibia 1 | 82
small heart 1 | 8
small kidney 1 | 10
small spleen 1 | 11
small superior vagus ganglion 1 | 20
small thymus 1 | 11
vertebral transformation 1 | 12

Disease

psoriasis 174 | 6,685
ovarian cancer 135 | 8,484
osteosarcoma 132 | 7,933
medulloblastoma, large-cell 123 | 6,234
diabetes mellitus 103 | 1,663
glioblastoma 101 | 5,572
lung cancer 93 | 4,466
interstitial cystitis 90 | 2,299
lung carcinoma 88 | 2,844
Cancer 81 | 2,346
atypical teratoid / rhabdoid tumor 80 | 4,369
ulcerative colitis 78 | 2,087
lung adenocarcinoma 77 | 2,713
pilocytic astrocytoma 72 | 3,086
invasive ductal carcinoma 67 | 2,950
non-small cell lung cancer 67 | 2,798
malignant mesothelioma 66 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 64 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,988
Carcinoma 59 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,289
adult high grade glioma 54 | 2,148
oligodendroglioma 52 | 2,849
pediatric high grade glioma 52 | 2,712
Breast cancer 51 | 3,094
ependymoma 51 | 2,514
primitive neuroectodermal tumor 51 | 3,031
tuberculosis 49 | 1,557
pancreatic cancer 48 | 2,300
pituitary cancer 48 | 1,972
colon cancer 47 | 1,475
cystic fibrosis 44 | 1,665
ductal carcinoma in situ 43 | 1,745
Asthma 41 | 349
cutaneous lupus erythematosus 40 | 1,056
subependymal giant cell astrocytoma 40 | 2,287
Obesity 39 | 616
breast carcinoma 39 | 1,614
posterior fossa group A ependymoma 39 | 1,511
astrocytic glioma 38 | 2,241
primary Sjogren syndrome 36 | 789
group 4 medulloblastoma 35 | 1,875
Pick disease 34 | 1,893
medulloblastoma 34 | 1,524
Rheumatoid Arthritis 33 | 1,160
Atopic dermatitis 31 | 944
Multiple Sclerosis 31 | 498
astrocytoma 31 | 1,493
Schizophrenia 28 | 501
adrenocortical carcinoma 27 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,795
Atherosclerosis 26 | 275
mucosa-associated lymphoid tissue lymphoma 26 | 480
sonic hedgehog group medulloblastoma 25 | 1,482
Hypertension 24 | 287
group 3 medulloblastoma 24 | 2,254
posterior fossa group B ependymoma 24 | 1,530
active Crohn's disease 23 | 918
gastric carcinoma 23 | 832
Coronary artery disease 21 | 240
Kidney disease 21 | 396
esophageal adenocarcinoma 21 | 737
juvenile dermatomyositis 21 | 1,189
Arthritis 20 | 248
Cerebrovascular disease 20 | 231
Hypertensive disease 20 | 193
Vascular disease 20 | 281
atypical teratoid/rhabdoid tumor 20 | 1,095
non primary Sjogren syndrome sicca 20 | 840
periodontitis 20 | 269
spina bifida 20 | 1,064
Lung disease 19 | 132
hepatocellular carcinoma 19 | 532
nasopharyngeal carcinoma 19 | 1,056
Allergic rhinitis 18 | 91
Hypersensitivity 18 | 63
Hypersensitivity reaction type II disease 18 | 235
Pneumonia 18 | 133
non-small cell lung carcinoma 18 | 413
primary pancreatic ductal adenocarcinoma 18 | 1,271
Endometriosis 17 | 535
Heart disease 17 | 279
Inflammation 17 | 109
Inflammatory bowel disease 17 | 142
Parkinson's disease 17 | 364
head and neck cancer 17 | 270
Alzheimer's disease 16 | 644
head and neck cancer and chronic obstructive pulmonary disease 16 | 237
sarcoidosis 16 | 358
Down syndrome 15 | 548
Epilepsy 15 | 346
fibroadenoma 15 | 557
Adenoma 14 | 165
Common cold 14 | 63
Crohn's disease 14 | 304
Dermatitis 14 | 107
Mammary Neoplasms 14 | 410
Peripheral vascular disease 14 | 90
Polycystic Ovary Syndrome 14 | 332
Prostatic Neoplasms 14 | 471

Tissue

Female tissues 571 | 18,647
Urinary Tract 546 | 18,444
Nervous System 505 | 18,561
Endocrine System 500 | 18,512
Digestive Tract 485 | 18,473
Skin and soft tissues 445 | 18,115
Liver and Pancreas 399 | 18,136
Blood and immune system 389 | 17,995
Cardiovascular System 377 | 17,958
Male tissues 358 | 17,969
Respiratory system 338 | 17,484

Target Family

oGPCR 326 | 421
GPCR 194 | 406
Non-IDG 122 | 11,971
Enzyme 13 | 4,146
Kinase 6 | 634
Ion Channel 2 | 341
Transcription Factor 2 | 1,400
Transporter 1 | 473

GO Process

G-protein coupled receptor sig... 666 | 666
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788