Development Level

Tdark 53 | 7,003
Tbio 43 | 10,625
Tchem 24 | 1,890
Tclin 8 | 602

IMPC Term

decreased body weight 3 | 174
decreased circulating creatini... 3 | 31
increased mean corpuscular hem... 3 | 93
preweaning lethality, complete... 3 | 633
abnormal coat/hair pigmentatio... 2 | 54
decreased circulating fructosa... 2 | 31
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal digit morphology 1 | 13
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
fused cornea and lens 1 | 4
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
impaired pupillary reflex 1 | 14
increased IgG1 level 1 | 1
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

osteosarcoma 54 | 7,933
ovarian cancer 45 | 8,484
psoriasis 36 | 6,685
Cancer 35 | 2,346
medulloblastoma, large-cell 32 | 6,234
lung cancer 30 | 4,466
interstitial cystitis 27 | 2,299
glioblastoma 26 | 5,572
atypical teratoid / rhabdoid tumor 21 | 4,369
lung carcinoma 20 | 2,844
non-small cell lung cancer 19 | 2,798
pancreatic cancer 19 | 2,300
Breast cancer 18 | 3,094
Multiple myeloma 18 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
lung adenocarcinoma 18 | 2,713
pilocytic astrocytoma 18 | 3,086
ulcerative colitis 18 | 2,087
Waldenstrons macroglobulinemia 17 | 765
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
oligodendroglioma 17 | 2,849
Carcinoma 16 | 2,147
invasive ductal carcinoma 16 | 2,950
juvenile dermatomyositis 16 | 1,189
subependymal giant cell astrocytoma 16 | 2,287
ependymoma 15 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
tuberculosis 15 | 1,557
cutaneous lupus erythematosus 14 | 1,056
primary Sjogren syndrome 14 | 789
medulloblastoma 13 | 1,524
primary pancreatic ductal adenocarcinoma 13 | 1,271
periodontitis 12 | 269
primitive neuroectodermal tumor 12 | 3,031
Pick disease 11 | 1,893
astrocytic glioma 11 | 2,241
chronic lymphosyte leukemia 11 | 232
diabetes mellitus 11 | 1,663
astrocytoma 10 | 1,493
pediatric high grade glioma 10 | 2,712
IGA Glomerulonephritis 9 | 454
Rheumatoid Arthritis 9 | 1,160
Wiskott-Aldrich syndrome 9 | 27
adult high grade glioma 9 | 2,148
colon cancer 9 | 1,475
cystic fibrosis 9 | 1,665
dermatomyositis 9 | 933
ductal carcinoma in situ 9 | 1,745
breast carcinoma 8 | 1,614
esophageal adenocarcinoma 8 | 737
malignant mesothelioma 8 | 3,162
mucosa-associated lymphoid tissue lymphoma 8 | 480
tuberculosis and treatment for 6 months 8 | 686
Amebiasis 7 | 22
Blastic phase chronic myeloid leukemia 7 | 58
Chronic Myelocytic Leukemia Accelerated Phase 7 | 59
Leukemia 7 | 88
group 4 medulloblastoma 7 | 1,875
sonic hedgehog group medulloblastoma 7 | 1,482
Alzheimer's disease 6 | 644
Kidney disease 6 | 396
Parkinson's disease 6 | 364
acute quadriplegic myopathy 6 | 1,157
cystic fibrosis and chronic rhinosinusitis 6 | 213
gastric carcinoma 6 | 832
pancreatic carcinoma 6 | 567
Arthritis 5 | 248
Chronic phase chronic myeloid leukemia 5 | 45
Down syndrome 5 | 548
Duchenne muscular dystrophy 5 | 602
Intellectual disability 5 | 573
Lymphoma 5 | 56
Mammary Neoplasms 5 | 410
Neoplasm Invasiveness 5 | 127
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Vascular disease 5 | 281
group 3 medulloblastoma 5 | 2,254
non-small cell lung carcinoma 5 | 413
spina bifida 5 | 1,064
Animal Mammary Neoplasms 4 | 136
Asthma 4 | 349
Cherubism 4 | 14
Chronic Lymphocytic Leukemia 4 | 242
HIV Infections 4 | 100
Liver carcinoma 4 | 217
Lung Neoplasms 4 | 171
Mammary Neoplasms, Experimental 4 | 150
Multiple Sclerosis 4 | 498
Neoplasm Metastasis 4 | 138
Prostatic Neoplasms 4 | 471
Squamous cell carcinoma 4 | 94
Stomach Neoplasms 4 | 282
acute myeloid leukemia 4 | 780
atypical teratoid/rhabdoid tumor 4 | 1,095
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 1,511
Schizophrenia 3 | 501

Tissue

Blood and immune system 113 | 17,995
Digestive Tract 113 | 18,473
Female tissues 113 | 18,647
Respiratory system 113 | 17,484
Liver and Pancreas 112 | 18,136
Skin and soft tissues 112 | 18,115
Urinary Tract 112 | 18,444
Cardiovascular System 111 | 17,958
Endocrine System 110 | 18,512
Nervous System 110 | 18,561
Male tissues 108 | 17,969

Target Family

Non-IDG 102 | 11,971
Kinase 18 | 634
Enzyme 8 | 4,146

GO Process

Fc-gamma receptor signaling pa... 128 | 128
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Immunoglobulin lambda variable 1-44 IGLV1-44 Tdark Non-IDG 0.00000 0
High affinity immunoglobulin gamma Fc receptor I FCGR1A Tchem Non-IDG -2.98035 1006.3 583
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A Tbio Non-IDG -2.87960 775.0 717
Immunoglobulin kappa variable 3-15 IGKV3-15 Tdark Non-IDG 0.00000 0