Development Level

Tbio 129 | 11,445
Tdark 23 | 6,588
Tchem 7 | 1,598
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 6 | 499
decreased circulating choleste... 5 | 93
embryonic lethality prior to t... 5 | 278
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal testis morphology 2 | 43
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased lactate dehydrogenas... 2 | 16
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal cecum morphology 1 | 7
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal stomach morphology 1 | 10
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
edema 1 | 59
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
thrombocytosis 1 | 27
tremors 1 | 39

Disease

ovarian cancer 105 | 8,520
Carcinoma 85 | 11,493
osteosarcoma 77 | 7,950
glioblastoma 63 | 5,792
psoriasis 56 | 6,694
medulloblastoma, large-cell 53 | 6,241
atypical teratoid / rhabdoid tumor 44 | 5,112
lung cancer 44 | 4,740
ependymoma 38 | 4,679
Breast cancer 35 | 3,578
Kidney cancer 33 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
lung adenocarcinoma 32 | 2,716
Multiple myeloma 29 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
adult high grade glioma 28 | 3,801
invasive ductal carcinoma 28 | 2,951
Astrocytoma, Pilocytic 27 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
malignant mesothelioma 27 | 3,232
Autosomal recessive predisposition 26 | 1,442
group 4 medulloblastoma 26 | 1,855
non-small cell lung cancer 24 | 2,890
pancreatic cancer 24 | 2,398
diabetes mellitus 23 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
tuberculosis 22 | 2,010
group 3 medulloblastoma 21 | 4,104
primitive neuroectodermal tumor 21 | 3,035
Cancer 20 | 2,499
astrocytoma 20 | 1,146
lung carcinoma 19 | 2,843
Pick disease 18 | 1,894
acute quadriplegic myopathy 18 | 1,158
astrocytic glioma 18 | 2,597
dermatomyositis 18 | 966
oligodendroglioma 18 | 2,850
subependymal giant cell astrocytoma 18 | 2,287
Intellectual disability 16 | 1,016
Rheumatoid arthritis 16 | 1,191
breast carcinoma 15 | 1,638
cystic fibrosis 14 | 1,696
spina bifida 14 | 1,074
Waldenstrons macroglobulinemia 13 | 765
hepatocellular carcinoma 13 | 547
interstitial cystitis 13 | 2,312
juvenile dermatomyositis 13 | 1,187
non primary Sjogren syndrome sicca 13 | 891
ulcerative colitis 13 | 1,819
tuberculosis and treatment for 6 months 12 | 409
Cognitive delay 11 | 608
Dull intelligence 11 | 645
Global developmental delay 11 | 608
Low intelligence 11 | 645
Melanoma 11 | 711
Mental Retardation 11 | 645
Mental and motor retardation 11 | 608
Mental deficiency 11 | 645
Poor school performance 11 | 645
cutaneous lupus erythematosus 11 | 1,057
pancreatic carcinoma 11 | 562
Bipolar Disorder 10 | 666
Schizophrenia 10 | 1,160
pediatric high grade glioma 10 | 1,064
Anemia 9 | 365
Neurodegenerative disease 9 | 414
Vascular disease 9 | 319
acute myeloid leukemia 9 | 783
colon cancer 9 | 1,478
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,109
Amyotrophic lateral sclerosis 8 | 451
Duchenne muscular dystrophy 8 | 601
Epilepsy 8 | 792
Liver cancer 8 | 604
Muscle hypotonia 8 | 571
active Crohn's disease 8 | 922
adrenocortical carcinoma 8 | 1,428
ductal carcinoma in situ 8 | 1,745
gastric cancer 8 | 459
gastric carcinoma 8 | 807
Congenital disorder of glycosylation 7 | 54
Coronary artery disease 7 | 268
Endometrial cancer 7 | 311
Heart disease 7 | 306
Neuropathy 7 | 261
Pulmonary embolism 7 | 55
Thrombophilia 7 | 38
Thrombosis 7 | 46
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
esophageal adenocarcinoma 7 | 737
hereditary spastic paraplegia 7 | 318
mucosa-associated lymphoid tissue lymphoma 7 | 484
Alzheimer's disease 6 | 658
Cerebrovascular disease 6 | 238
Hypertension 6 | 396
Variable expressivity 6 | 157
posterior fossa group A ependymoma 6 | 468
progressive supranuclear palsy 6 | 676
sonic hedgehog group medulloblastoma 6 | 467

Tissue

Endocrine System 157 | 18,159
Liver and Pancreas 157 | 16,750
Skin and soft tissues 157 | 17,230
Digestive Tract 156 | 17,369
Female tissues 156 | 17,400
Urinary Tract 156 | 16,678
Male tissues 155 | 17,142
Nervous System 154 | 16,725
Blood and immune system 153 | 16,909
Respiratory system 153 | 16,393
Cardiovascular System 150 | 15,192

Target Family

Non-IDG 134 | 12,091
Enzyme 23 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

GO Process

ER to Golgi vesicle-mediated t... 162 | 162
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Lipase maturation factor 1 LMF1 Tbio Enzyme -1.30021 24.5 35
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Conserved oligomeric Golgi complex subunit 1 COG1 Tbio Non-IDG -1.68066 45.6 91
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236
Trafficking protein particle complex subunit 8 TRAPPC8 Tdark Non-IDG -1.08378 10.2 5
Melanoma inhibitory activity protein 2 CTAGE5 Tbio Non-IDG 0.00000 91
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.74914 5601.8 1083