Development Level

Tbio 13 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 2 | 239
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal stomach morphology 1 | 10
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
male infertility 1 | 123

Disease

ovarian cancer 12 | 8,520
osteosarcoma 11 | 7,950
Carcinoma 9 | 11,493
group 3 medulloblastoma 9 | 4,104
medulloblastoma, large-cell 7 | 6,241
primitive neuroectodermal tumor 7 | 3,035
psoriasis 7 | 6,694
glioblastoma 6 | 5,792
Breast cancer 5 | 3,578
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung cancer 5 | 4,740
Cancer 4 | 2,499
adult high grade glioma 4 | 3,801
malignant mesothelioma 4 | 3,232
Astrocytoma, Pilocytic 3 | 3,081
Bell Palsy 3 | 58
Blepharoptosis 3 | 231
Facial Paresis 3 | 59
Facial muscle weakness of muscles innervated by CN VII 3 | 58
Muscle hypotonia 3 | 571
Neuropathy 3 | 261
acute quadriplegic myopathy 3 | 1,158
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Adult onset 2 | 82
Alzheimer's disease 2 | 658
Atrophy of cerebellum 2 | 103
Autosomal recessive predisposition 2 | 1,442
Cerebellar Ataxia 2 | 304
Cerebellar degeneration 2 | 103
Chronic Lymphocytic Leukemia 2 | 262
Chronic progressive external ophthalmoplegia 2 | 26
Colonic Neoplasms 2 | 142
Creatine phosphokinase serum increased 2 | 110
Decreased activity of cytochrome C oxidase in muscle tissue 2 | 10
Deglutition Disorders 2 | 132
Elevated creatine kinase 2 | 110
Epilepsy 2 | 792
Highly variable severity 2 | 157
Impaired exercise tolerance 2 | 42
Increased serum lactate 2 | 60
Infratentorial atrophy 2 | 103
Kidney cancer 2 | 2,613
Motor delay 2 | 147
Multiple mitochondrial DNA (mtDNA) deletions 2 | 5
Muscle weakness of limb 2 | 21
Muscle weakness, progressive 2 | 22
Neurodegenerative disease 2 | 414
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
No development of motor milestones 2 | 147
Pick disease 2 | 1,894
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1 2 | 5
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 2 | 5
Progressive disorder 2 | 142
Rapidly progressive 2 | 27
Rapidly progressive disorder 2 | 27
Reflex, Deep Tendon, Absent 2 | 92
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Skeletal muscle atrophy 2 | 139
Variable expressivity 2 | 157
Xeroderma pigmentosum 2 | 43
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
juvenile dermatomyositis 2 | 1,187
muscle degeneration 2 | 139
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
subependymal giant cell astrocytoma 2 | 2,287
Ataxia, Appendicular 1 | 25
Chloracne 1 | 32
Cortical blindness 1 | 16
Everted lower lip vermilion 1 | 54
Gastroenteritis 1 | 41
Gastroparesis 1 | 22
Mask-like facies 1 | 25
Micronodular cirrhosis 1 | 12
Mitral Valve Prolapse Syndrome 1 | 39
Mitral regurgitation, mild 1 | 32
Muscle Rigidity 1 | 49
Paraparesis, Spastic 1 | 16
Premature Menopause 1 | 31
Primary hypogonadism 1 | 37
Primary physiologic amenorrhea 1 | 55
Progressive microcephaly 1 | 32
Protruding lower lip 1 | 54
Resting Tremor 1 | 9
Tonic - clonic seizures 1 | 44
Xeroderma pigmentosum group E 1 | 3

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 10 | 4,145
Non-IDG 4 | 12,091
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

DNA-dependent DNA replication 16 | 16
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mini-chromosome maintenance complex-binding protein MCMBP Tbio Non-IDG -0.65233 5.60 92
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
DNA polymerase nu POLN Tbio Enzyme -2.17621 148.9 60
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
DNA polymerase theta POLQ Tbio Enzyme -1.61640 40.0 57
DNA polymerase zeta catalytic subunit REV3L Tbio Enzyme -2.20108 158.5 41
Bromodomain adjacent to zinc finger domain protein 1A BAZ1A Tbio Epigenetic -1.49900 29.7 91
Transcription factor A, mitochondrial TFAM Tbio Transcription Factor -2.72618 499.4 378
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350