Development Level

Tbio 111 | 11,178
Tchem 21 | 1,885
Tclin 8 | 612
Tdark 2 | 6,569

IMPC Phenotype

preweaning lethality, complete... 22 | 979
embryonic lethality prior to o... 14 | 239
embryonic lethality prior to t... 10 | 278
preweaning lethality, incomple... 6 | 499
abnormal embryo size 4 | 220
increased bone mineral density 4 | 72
abnormal behavior 3 | 298
decreased circulating glucose ... 3 | 126
decreased lean body mass 3 | 135
increased bone mineral content 3 | 108
abnormal behavioral response t... 2 | 66
abnormal blood vessel morpholo... 2 | 5
abnormal coat- hair morphology 2 | 19
abnormal embryo turning 2 | 31
abnormal eye morphology 2 | 68
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal placement of pupils 1 | 6
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased startle reflex 1 | 112
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 100 | 11,192
osteosarcoma 83 | 7,766
ovarian cancer 83 | 8,297
group 3 medulloblastoma 73 | 4,002
medulloblastoma, large-cell 65 | 6,086
psoriasis 64 | 6,514
lung cancer 63 | 4,607
malignant mesothelioma 59 | 3,135
atypical teratoid / rhabdoid tumor 57 | 4,971
glioblastoma 56 | 5,635
Breast cancer 55 | 3,469
non-small cell lung cancer 54 | 2,799
Cancer 48 | 2,388
primitive neuroectodermal tumor 47 | 2,957
ependymoma 41 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,204
adrenocortical carcinoma 38 | 1,385
lung adenocarcinoma 37 | 2,627
invasive ductal carcinoma 35 | 2,867
colon cancer 32 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,902
adult high grade glioma 31 | 3,701
ductal carcinoma in situ 28 | 1,686
nasopharyngeal carcinoma 28 | 1,024
oligodendroglioma 27 | 2,768
Kidney cancer 26 | 2,548
Autosomal recessive predisposition 24 | 1,407
breast carcinoma 20 | 1,589
astrocytic glioma 19 | 2,530
Endometriosis 17 | 521
Waldenstrons macroglobulinemia 17 | 742
pediatric high grade glioma 16 | 1,035
Fetal Growth Retardation 15 | 186
Infant, Small for Gestational Age 15 | 174
Intrauterine retardation 15 | 174
Multiple myeloma 15 | 1,296
Pick disease 15 | 1,856
Small head 15 | 366
tuberculosis 15 | 1,963
Intellectual disability 14 | 998
Seckel syndrome 14 | 34
Short stature 14 | 514
Astrocytoma, Pilocytic 13 | 3,006
Dull intelligence 13 | 634
Low intelligence 13 | 634
Mental Retardation 13 | 634
Mental deficiency 13 | 634
Poor school performance 13 | 634
astrocytoma 13 | 1,113
ulcerative colitis 13 | 1,765
Bloom syndrome 12 | 29
Hypoplastic mandible condyle 12 | 273
Mandibular hypoplasia 12 | 273
Micrognathism 12 | 273
diabetes mellitus 12 | 1,683
pancreatic cancer 12 | 2,322
pituitary cancer 12 | 1,915
subependymal giant cell astrocytoma 12 | 2,230
Ataxia telangiectasia 11 | 33
Atopic dermatitis 11 | 915
Microcephaly 11 | 166
group 4 medulloblastoma 11 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,872
Cryptorchidism 10 | 287
dermatomyositis 10 | 941
Breast Neoplasms 9 | 423
Delayed bone age 9 | 132
Fanconi anemia 9 | 56
Mammary Neoplasms 9 | 403
Werner syndrome 9 | 29
acute quadriplegic myopathy 9 | 1,133
interstitial cystitis 9 | 2,237
lung carcinoma 9 | 2,755
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,911
Alzheimer's disease 8 | 640
Failure to gain weight 8 | 359
Narrow face 8 | 54
Nijmegen breakage syndrome 8 | 23
Pediatric failure to thrive 8 | 359
Prostatic Neoplasms 8 | 472
Rothmund-Thomson syndrome 8 | 19
Thin face 8 | 54
Xeroderma pigmentosum 8 | 42
juvenile dermatomyositis 8 | 1,147
Bilateral fifth finger clinodactyly 7 | 109
Bipolar Disorder 7 | 646
Colorectal Neoplasms 7 | 235
Convex nasal ridge 7 | 36
Curvature of little finger 7 | 109
Deafness 7 | 193
Malignant tumor of ovary 7 | 25
Meier-Gorlin syndrome 7 | 10
Seizures 7 | 584
Strabismus 7 | 265
Telangiectasis 7 | 35
acute myeloid leukemia 7 | 760
esophageal adenocarcinoma 7 | 696
gastric cancer 7 | 445
non primary Sjogren syndrome sicca 7 | 861
progressive supranuclear palsy 7 | 656

Tissue

Digestive Tract 138 | 17,369
Endocrine System 138 | 18,159
Female tissues 138 | 17,400
Nervous System 138 | 16,725
Skin and soft tissues 138 | 17,230
Urinary Tract 138 | 16,678
Blood and immune system 137 | 16,909
Liver and Pancreas 137 | 16,750
Male tissues 137 | 17,142
Respiratory system 137 | 16,393
Cardiovascular System 133 | 15,192

Target Family

Non-IDG 76 | 12,091
Enzyme 47 | 4,145
Transcription Factor 8 | 1,400
Kinase 6 | 634
Epigenetic 4 | 242
TF/Epigenetic 1 | 38

GO Process

DNA replication 142 | 142
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
DNA/RNA-binding protein KIN17 KIN Tbio Non-IDG -2.35273 226.2 92
Nuclear receptor coactivator 6 NCOA6 Tbio Non-IDG -1.83369 72.1 54
5'(3')-deoxyribonucleotidase, mitochondrial NT5M Tchem Enzyme -2.92598 803.3 44
DNA repair protein REV1 REV1 Tbio Non-IDG -2.43956 286.1 101
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Protein SPHAR SPHAR Tdark Non-IDG -1.04402 9.78 18
Nuclear factor 1 X-type NFIX Tbio Transcription Factor -1.70265 49.7 74
Glutamate-rich WD repeat-containing protein 1 GRWD1 Tbio Non-IDG -0.77781 6.68 103
DNA replication licensing factor MCM6 MCM6 Tbio Non-IDG -1.99059 90.3 260