Development Level

Tbio 161 | 11,651
Tchem 27 | 1,388
Tdark 12 | 6,593
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to t... 14 | 278
embryonic lethality prior to o... 12 | 239
preweaning lethality, incomple... 11 | 499
abnormal embryo size 6 | 220
decreased body weight 6 | 161
abnormal bone structure 5 | 187
abnormal coat-hair pigmentatio... 4 | 64
abnormal heart morphology 4 | 162
decreased bone mineral content 4 | 151
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased mean corpuscular vol... 4 | 92
abnormal behavior 3 | 298
abnormal embryo turning 3 | 31
abnormal retina morphology 3 | 71
increased circulating alkaline... 3 | 122
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
abnormal coat- hair morphology 2 | 19
abnormal cornea morphology 2 | 31
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
cataract 2 | 92
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
increased erythrocyte cell num... 2 | 39
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube morpholog... 1 | 12
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vitreous body morphol... 1 | 10
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
iris synechia 1 | 3
limb grasping 1 | 41
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 144 | 11,493
ovarian cancer 123 | 8,520
osteosarcoma 115 | 7,950
medulloblastoma, large-cell 84 | 6,241
group 3 medulloblastoma 82 | 4,104
psoriasis 78 | 6,694
lung cancer 75 | 4,740
glioblastoma 71 | 5,792
Cancer 69 | 2,499
atypical teratoid / rhabdoid tumor 68 | 5,112
malignant mesothelioma 63 | 3,232
Breast cancer 61 | 3,578
primitive neuroectodermal tumor 49 | 3,035
ependymoma 47 | 4,679
non-small cell lung cancer 42 | 2,890
Kidney cancer 40 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
oligodendroglioma 39 | 2,850
lung adenocarcinoma 38 | 2,716
adult high grade glioma 37 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
Autosomal recessive predisposition 35 | 1,442
Intellectual disability 31 | 1,016
invasive ductal carcinoma 30 | 2,951
astrocytic glioma 28 | 2,597
Short stature 27 | 531
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Pick disease 26 | 1,894
Poor school performance 26 | 645
adrenocortical carcinoma 26 | 1,428
colon cancer 26 | 1,478
Small head 25 | 374
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
diabetes mellitus 24 | 1,728
Fanconi anemia 22 | 56
Xeroderma pigmentosum 21 | 43
pancreatic cancer 21 | 2,398
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Waldenstrons macroglobulinemia 20 | 765
Cryptorchidism 19 | 296
nasopharyngeal carcinoma 19 | 1,058
Cockayne syndrome 18 | 60
Epilepsy 18 | 792
Multiple myeloma 18 | 1,332
subependymal giant cell astrocytoma 18 | 2,287
tuberculosis 18 | 2,010
Astrocytoma, Pilocytic 17 | 3,081
Melanoma 17 | 711
Seizures 17 | 596
breast carcinoma 17 | 1,638
pituitary cancer 17 | 1,972
ulcerative colitis 17 | 1,819
acute quadriplegic myopathy 16 | 1,158
juvenile dermatomyositis 16 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
progressive supranuclear palsy 16 | 676
Acquired scoliosis 15 | 281
Bloom syndrome 15 | 29
Curvature of spine 15 | 282
Strabismus 15 | 270
Thrombocytopenia 15 | 197
ductal carcinoma in situ 15 | 1,745
hypopigmented skin patch 15 | 59
Breast Neoplasms 14 | 445
Decreased platelet count 14 | 111
Mammary Neoplasms 14 | 425
Rheumatoid arthritis 14 | 1,191
group 4 medulloblastoma 14 | 1,855
Chromosome Breakage 13 | 36
Fetal Growth Retardation 13 | 189
Infant, Small for Gestational Age 13 | 176
Intrauterine retardation 13 | 176
Sensorineural Hearing Loss (disorder) 13 | 284
astrocytoma 13 | 1,146
Anemia 12 | 365
Endometriosis 12 | 540
Fatigue 12 | 182
Increased chromosomal breakage 12 | 27
Leukopenia 12 | 72
Muscle hypotonia 12 | 571
Neurodegenerative disease 12 | 414
Telangiectasis 12 | 36
acute myeloid leukemia 12 | 783
dermatomyositis 12 | 966
Almond-shaped eyes 11 | 23
Failure to gain weight 11 | 365
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Pediatric failure to thrive 11 | 365
Radial aplasia/hypoplasia 11 | 29
hepatocellular carcinoma 11 | 547
pediatric high grade glioma 11 | 1,064
Alzheimer's disease 10 | 658
Atopic dermatitis 10 | 952

Tissue

Blood and immune system 205 | 16,909
Endocrine System 205 | 18,159
Female tissues 205 | 17,400
Urinary Tract 205 | 16,678
Liver and Pancreas 204 | 16,750
Nervous System 204 | 16,725
Digestive Tract 203 | 17,369
Male tissues 203 | 17,142
Skin and soft tissues 203 | 17,230
Respiratory system 202 | 16,393
Cardiovascular System 199 | 15,192

Target Family

Non-IDG 115 | 12,091
Enzyme 64 | 4,145
Kinase 11 | 634
Transcription Factor 8 | 1,400
Epigenetic 7 | 242
Ion Channel 1 | 344

GO Process

DNA repair 206 | 206
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.66230 41.9 193
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
Ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 Tbio Enzyme -1.71687 51.9 225