Development Level

Tbio 138 | 10,625
Tchem 33 | 1,890
Tdark 19 | 7,003
Tclin 6 | 602

IMPC Term

preweaning lethality, complete... 23 | 633
embryonic lethality prior to t... 10 | 187
embryonic lethality prior to o... 9 | 148
preweaning lethality, incomple... 7 | 260
decreased body weight 5 | 174
increased or absent threshold ... 5 | 128
abnormal behavior 4 | 226
decreased grip strength 4 | 123
increased fasted circulating g... 4 | 68
increased mean corpuscular vol... 4 | 91
abnormal coat/hair pigmentatio... 3 | 54
abnormal embryo size 3 | 112
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
narrow eye opening 3 | 15
abnormal bone structure 2 | 131
abnormal coat/ hair morphology 2 | 18
abnormal cornea morphology 2 | 24
abnormal placement of pupils 2 | 4
decreased body length 2 | 108
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
enlarged heart 2 | 111
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased mean corpuscular hem... 2 | 93
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal foot plate morphology 1 | 2
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 51
abnormal heart position or ori... 1 | 1
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
anophthalmia 1 | 20
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased blood urea nitrogen ... 1 | 31
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased startle reflex 1 | 48
decreased thoracic vertebrae n... 1 | 7
embryonic growth retardation 1 | 28
enlarged epididymis 1 | 27
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating aspartat... 1 | 17
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 25
increased respiratory quotient 1 | 12
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
pale yolk sac 1 | 12
small adrenal glands 1 | 15
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 118 | 8,484
osteosarcoma 108 | 7,933
medulloblastoma, large-cell 81 | 6,234
psoriasis 78 | 6,685
lung cancer 68 | 4,466
glioblastoma 65 | 5,572
Cancer 61 | 2,346
malignant mesothelioma 60 | 3,162
group 3 medulloblastoma 55 | 2,254
Breast cancer 51 | 3,094
atypical teratoid / rhabdoid tumor 51 | 4,369
primitive neuroectodermal tumor 47 | 3,031
oligodendroglioma 40 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
non-small cell lung cancer 38 | 2,798
lung adenocarcinoma 35 | 2,713
pediatric high grade glioma 35 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
Carcinoma 30 | 2,147
invasive ductal carcinoma 30 | 2,950
Pick disease 26 | 1,893
adrenocortical carcinoma 26 | 1,427
astrocytic glioma 26 | 2,241
ependymoma 26 | 2,514
colon cancer 25 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
sonic hedgehog group medulloblastoma 24 | 1,482
diabetes mellitus 21 | 1,663
Fanconi's anemia 20 | 50
atypical teratoid/rhabdoid tumor 20 | 1,095
Waldenstrons macroglobulinemia 18 | 765
nasopharyngeal carcinoma 18 | 1,056
pancreatic cancer 18 | 2,300
subependymal giant cell astrocytoma 18 | 2,287
ulcerative colitis 18 | 2,087
Multiple myeloma 17 | 1,327
Xeroderma pigmentosum 17 | 41
posterior fossa group A ependymoma 17 | 1,511
Peripheral Neuropathy 16 | 303
acute quadriplegic myopathy 16 | 1,157
astrocytoma 16 | 1,493
breast carcinoma 16 | 1,614
juvenile dermatomyositis 16 | 1,189
pituitary cancer 16 | 1,972
progressive supranuclear palsy 16 | 674
Bloom syndrome 15 | 30
Rheumatoid Arthritis 15 | 1,160
ductal carcinoma in situ 15 | 1,745
pilocytic astrocytoma 15 | 3,086
Cockayne syndrome 14 | 54
Mammary Neoplasms 14 | 410
tuberculosis 14 | 1,557
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
acute myeloid leukemia 12 | 780
adult high grade glioma 12 | 2,148
dermatomyositis 12 | 933
medulloblastoma 12 | 1,524
Endometriosis 11 | 535
IGA Glomerulonephritis 11 | 454
Intellectual disability 11 | 573
Melanoma 11 | 261
Neoplastic Syndromes, Hereditary 11 | 48
Neurodegenerative disease 11 | 383
tuberculosis and treatment for 6 months 11 | 686
Anemia 10 | 252
Atopic dermatitis 10 | 944
group 4 medulloblastoma 10 | 1,875
hepatocellular carcinoma 10 | 532
Fanconi Anemia 9 | 19
Lynch syndrome 9 | 33
gastric cancer 9 | 430
Ataxia telangiectasia 8 | 31
Stomach Neoplasms 8 | 282
Werner syndrome 8 | 29
lung carcinoma 8 | 2,844
posterior fossa group B ependymoma 8 | 1,530
primary Sjogren syndrome 8 | 789
spina bifida 8 | 1,064
Alzheimer's disease 7 | 644
Chronic Lymphocytic Leukemia 7 | 242
Down syndrome 7 | 548
Nijmegen breakage syndrome 7 | 23
aldosterone-producing adenoma 7 | 664
cystic fibrosis 7 | 1,665
inflammatory breast cancer 7 | 404
interstitial cystitis 7 | 2,299
non primary Sjogren syndrome sicca 7 | 840
Adenoma 6 | 165
Bladder Neoplasm 6 | 109
Colorectal Neoplasms 6 | 217
Microcephaly 6 | 149
Photosensitive trichothiodystrophy 6 | 24
Prostatic Neoplasms 6 | 471
Seckel syndrome 6 | 34
pancreatic carcinoma 6 | 567
Amyotrophic Lateral Sclerosis 5 | 431
Liver carcinoma 5 | 217
esophageal adenocarcinoma 5 | 737
non-small cell lung carcinoma 5 | 413
primary pancreatic ductal adenocarcinoma 5 | 1,271

Tissue

Blood and immune system 196 | 17,995
Digestive Tract 196 | 18,473
Liver and Pancreas 196 | 18,136
Male tissues 196 | 17,969
Cardiovascular System 195 | 17,958
Female tissues 195 | 18,647
Nervous System 195 | 18,561
Endocrine System 194 | 18,512
Respiratory system 194 | 17,484
Urinary Tract 194 | 18,444
Skin and soft tissues 193 | 18,115

Target Family

Non-IDG 107 | 11,971
Enzyme 62 | 4,146
Kinase 12 | 634
Epigenetic 7 | 242
Transcription Factor 7 | 1,400
Ion Channel 1 | 341

GO Process

DNA repair 196 | 196
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.16121 152.6 207
ATP-dependent DNA helicase Q1 RECQL Tbio Enzyme -1.84578 76.6 72