Development Level

Tbio 11 | 11,445
Tchem 6 | 1,598

IMPC Phenotype

decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating sodium l... 2 | 71
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased kidney weight 1 | 6
increased lean body mass 1 | 172
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 14 | 11,493
osteosarcoma 14 | 7,950
Cancer 12 | 2,499
glioblastoma 12 | 5,792
malignant mesothelioma 12 | 3,232
ovarian cancer 12 | 8,520
lung cancer 10 | 4,740
medulloblastoma, large-cell 10 | 6,241
atypical teratoid / rhabdoid tumor 9 | 5,112
psoriasis 9 | 6,694
adult high grade glioma 8 | 3,801
Breast cancer 7 | 3,578
Lung Neoplasms 7 | 232
Breast Neoplasms 6 | 445
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
non-small cell lung cancer 6 | 2,890
Ataxia telangiectasia 5 | 34
Mammary Neoplasms 5 | 425
Pancreatic Neoplasm 5 | 85
Prostatic Neoplasms 5 | 495
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 167
Anemia 4 | 365
Astrocytoma, Pilocytic 4 | 3,081
Cell Transformation, Neoplastic 4 | 97
Colorectal Neoplasms 4 | 243
Hereditary Breast and Ovarian Cancer Syndrome 4 | 14
Kidney cancer 4 | 2,613
Li-Fraumeni syndrome 4 | 13
Neoplastic Cell Transformation 4 | 89
Pancreatic Neoplasms 4 | 85
Rheumatoid arthritis 4 | 1,191
Stomach Neoplasms 4 | 300
colon cancer 4 | 1,478
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
Colonic Neoplasms 3 | 142
DOID:2627 3 | 94
Endometriosis 3 | 540
Gastrointestinal stromal tumor 3 | 62
Glioma 3 | 74
Liver cancer 3 | 604
Lynch syndrome 3 | 35
Malignant neoplasm of breast 3 | 15
Mesothelioma, Malignant 3 | 105
Multiple myeloma 3 | 1,332
Neoplasms, Squamous Cell 3 | 3
Nijmegen breakage syndrome 3 | 24
Ovarian Neoplasms 3 | 102
Pancreatic carcinoma, familial 3 | 8
Prostate cancer 3 | 175
Prostate cancer, familial 3 | 13
Renal Cell Carcinoma 3 | 214
Schizophrenia 3 | 1,160
Squamous Cell Neoplasms 3 | 3
acute quadriplegic myopathy 3 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
dermatomyositis 3 | 966
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
ovarian neoplasm 3 | 99
pancreatic cancer 3 | 2,398
Abnormality of metabolism/homeostasis 2 | 134
Adenoid Cystic Carcinoma 2 | 99
Amyotrophic lateral sclerosis 2 | 451
Bladder Neoplasm 2 | 112
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Transitional Cell 2 | 32
Endometrial cancer 2 | 311
Esophageal Squamous Cell Carcinoma 2 | 77
Leukemia 2 | 104
Leukopenia 2 | 72
Liver carcinoma 2 | 240
Lymphoid leukemia 2 | 160
Lymphoma 2 | 81
Melanoma 2 | 711
Neoplasm Metastasis 2 | 168
Sarcoma 2 | 62
Skin cancer 2 | 469
Somatic mutation 2 | 61
Squamous cell carcinoma 2 | 129
Squamous cell carcinoma of esophagus 2 | 77
Thrombocytopenia 2 | 197
Urinary Bladder Neoplasms 2 | 114
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
hereditary spastic paraplegia 2 | 318
non-small cell lung carcinoma 2 | 317
posterior fossa group A ependymoma 2 | 468
tuberculosis 2 | 2,010

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Cardiovascular System 16 | 15,192

Target Family

Non-IDG 5 | 12,091
Transcription Factor 5 | 1,400
Kinase 3 | 634
Epigenetic 2 | 242
Enzyme 1 | 4,145
TF/Epigenetic 1 | 38

GO Process

DNA damage response, signal tr... 17 | 17
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Inhibitor of growth protein 4 ING4 Tbio Epigenetic -1.76632 69.3 193
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
40S ribosomal protein S27-like RPS27L Tbio Non-IDG -0.44716 3.07 56
Tumor protein p73 TP73 Tbio Transcription Factor -1.92832 82.6 708
RNA-binding protein 38 RBM38 Tbio Non-IDG -1.34664 26.4 80
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298