Development Level

Tbio 27 | 11,445
Tchem 5 | 1,598
Tdark 4 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
preweaning lethality, incomple... 3 | 499
decreased circulating triglyce... 2 | 79
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal inner nuclear... 1 | 8
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 25 | 8,520
Carcinoma 19 | 11,493
lung cancer 19 | 4,740
medulloblastoma, large-cell 16 | 6,241
malignant mesothelioma 15 | 3,232
osteosarcoma 15 | 7,950
psoriasis 15 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
group 3 medulloblastoma 13 | 4,104
glioblastoma 12 | 5,792
primitive neuroectodermal tumor 12 | 3,035
non-small cell lung cancer 11 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Breast cancer 8 | 3,578
Cancer 8 | 2,499
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
oligodendroglioma 7 | 2,850
astrocytic glioma 6 | 2,597
diabetes mellitus 6 | 1,728
nasopharyngeal carcinoma 6 | 1,058
Multiple myeloma 5 | 1,332
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
invasive ductal carcinoma 5 | 2,951
pituitary cancer 5 | 1,972
Amyotrophic lateral sclerosis 4 | 451
Chronic Lymphocytic Leukemia 4 | 262
Intellectual disability 4 | 1,016
Kyphosis deformity of spine 4 | 114
Short stature 4 | 531
Xeroderma pigmentosum 4 | 43
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,187
pancreatic cancer 4 | 2,398
Alzheimer's disease 3 | 658
Anemia 3 | 365
Autosomal recessive predisposition 3 | 1,442
Cockayne syndrome 3 | 60
Colorectal Neoplasms 3 | 243
Epilepsy 3 | 792
Hyperkyphosis 3 | 111
Hypoplastic mandible condyle 3 | 275
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Pick disease 3 | 1,894
Seizures 3 | 596
Stevens-Johnson syndrome 3 | 92
Tremor 3 | 113
esophageal adenocarcinoma 3 | 737
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
Acquired scoliosis 2 | 281
Adenoid Cystic Carcinoma 2 | 99
Atrophy of cerebellum 2 | 103
Bilateral fifth finger clinodactyly 2 | 110
Blepharophimosis 2 | 70
Brain Ischemia 2 | 110
Carcinoma, Adenoid Cystic 2 | 99
Cerebellar degeneration 2 | 103
Cerebrovascular disease 2 | 238
Coarse facial features 2 | 108
Colonic Neoplasms 2 | 142
Congenital pes cavus 2 | 88
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Disease Progression 2 | 136
Endometriosis 2 | 540
Hernia, Inguinal 2 | 89
Infratentorial atrophy 2 | 103
Kidney cancer 2 | 2,613
Macroglossia 2 | 65
Melanoma 2 | 711
Rheumatoid arthritis 2 | 1,191
Sensorineural Hearing Loss (disorder) 2 | 284
Severe mental retardation (I.Q. 20-34) 2 | 99
Stomach Neoplasms 2 | 300
Thickened facial skin with coarse facial features 2 | 108
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis and chronic rhinosinusitis 2 | 214
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 38 | 16,909
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 9 | 4,145
Transcription Factor 3 | 1,400
Kinase 1 | 634

GO Process

DNA damage response, detection... 38 | 38
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Zinc finger and BTB domain-containing protein 32 ZBTB32 Tbio Transcription Factor -2.17117 142.7 132
28S ribosomal protein S26, mitochondrial MRPS26 Tdark Non-IDG -0.22018 1.24 61
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Serine/threonine-protein kinase Nek1 NEK1 Tchem Kinase -1.62443 47.0 85
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.19489 157.7 218
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Protein C21orf2 C21orf2 Tbio Non-IDG -1.72710 41.9 119