Development Level

Tbio 20 | 11,445
Tchem 9 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
increased circulating sodium l... 2 | 71
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
embryonic growth retardation 1 | 106
increased erythrocyte cell num... 1 | 39
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 23 | 11,493
ovarian cancer 22 | 8,520
osteosarcoma 18 | 7,950
Breast cancer 14 | 3,578
Cancer 14 | 2,499
glioblastoma 14 | 5,792
lung cancer 14 | 4,740
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
group 3 medulloblastoma 12 | 4,104
psoriasis 12 | 6,694
ependymoma 10 | 4,679
invasive ductal carcinoma 10 | 2,951
malignant mesothelioma 10 | 3,232
Kidney cancer 9 | 2,613
non-small cell lung cancer 8 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
Ataxia telangiectasia 6 | 34
Nijmegen breakage syndrome 6 | 24
adult high grade glioma 6 | 3,801
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
astrocytic glioma 5 | 2,597
nasopharyngeal carcinoma 5 | 1,058
pancreatic cancer 5 | 2,398
Fanconi anemia 4 | 56
Microcephaly 4 | 166
Seckel syndrome 4 | 34
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
juvenile dermatomyositis 4 | 1,187
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
tuberculosis and treatment for 6 months 4 | 409
Bloom syndrome 3 | 29
Cleft Palate 3 | 271
Fetal Growth Retardation 3 | 189
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
Hypoplastic mandible condyle 3 | 275
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Malignant neoplasm of breast 3 | 15
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
Uranostaphyloschisis 3 | 167
gastric carcinoma 3 | 807
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
non primary Sjogren syndrome sicca 3 | 891
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Bipolar Disorder 2 | 666
Byzanthine arch palate 2 | 194
Curvature of spine 2 | 282
Delayed bone age 2 | 136
Down syndrome 2 | 499
Downward slant of palpebral fissure 2 | 158
Endometriosis 2 | 540
Exophthalmos 2 | 112
Glaucoma 2 | 239
Joint hyperflexibility 2 | 78
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Major Depressive Disorder 2 | 301
Neuroblastoma 2 | 80
Penile hypospadias 2 | 106
Prostate cancer 2 | 175
Strabismus 2 | 270
Unipolar Depression 2 | 250
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Cardiovascular System 29 | 15,192

Target Family

Non-IDG 17 | 12,091
Kinase 6 | 634
Enzyme 2 | 4,145
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

GO Process

DNA damage checkpoint 30 | 30
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RHNO1 Tbio Non-IDG -3.20363 1560.8 3
Integrator complex subunit 7 INTS7 Tdark Non-IDG -0.82823 6.83 37
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Tchem Kinase -1.18567 14.9 215
Protein downstream neighbor of Son DONSON Tbio Non-IDG -0.72661 4.41 56
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Histone-lysine N-methyltransferase, H3 lysine-79 specific DOT1L Tchem Epigenetic -2.29797 199.6 330
eIF-2-alpha kinase GCN2 EIF2AK4 Tchem Kinase -2.43702 276.5 301
TIP41-like protein TIPRL Tbio Non-IDG -1.56096 34.8 154