Development Level

Tbio 32 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
abnormal embryo size 1 | 220
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 19 | 8,520
Carcinoma 16 | 11,493
Cockayne syndrome 11 | 60
osteosarcoma 11 | 7,950
Photosensitive trichothiodystrophy 10 | 30
lung cancer 10 | 4,740
Xeroderma pigmentosum group B 8 | 20
glioblastoma 6 | 5,792
psoriasis 6 | 6,694
Kidney cancer 5 | 2,613
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group D 5 | 33
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
medulloblastoma, large-cell 5 | 6,241
Breast cancer 4 | 3,578
Hereditary spherocytosis type 5 4 | 12
Multiple myeloma 4 | 1,332
Xeroderma pigmentosum group G 4 | 16
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
group 4 medulloblastoma 4 | 1,855
primitive neuroectodermal tumor 4 | 3,035
Cancer 3 | 2,499
Keratitis 3 | 62
Pick disease 3 | 1,894
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
group 3 medulloblastoma 3 | 4,104
hepatocellular carcinoma 3 | 547
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
Arthralgia 2 | 90
Astrocytoma, Pilocytic 2 | 3,081
Atrophic condition of skin 2 | 25
Basal cell carcinoma 2 | 54
Basal cell nevi 2 | 23
Brittle hair 2 | 25
Cachexia 2 | 50
Congenital deafness 2 | 185
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Dental abnormalities 2 | 60
Developmental regression 2 | 95
Dry skin 2 | 75
Electroencephalogram abnormal 2 | 101
Erythema 2 | 58
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fever 2 | 138
Flushing 2 | 60
Fractured hair 2 | 25
Fragile hair 2 | 25
Freckles 2 | 33
Hearing Loss, Partial 2 | 185
Hyperkeratosis 2 | 50
Hyperpigmented macules 2 | 42
Impaired cognition 2 | 96
Loss of developmental milestones 2 | 95
Melanoma 2 | 711
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Mixed connective tissue disease 2 | 16
Muscle Spasticity 2 | 195
Neurodevelopmental regression 2 | 95
Papilloma 2 | 44
Pediatric failure to thrive 2 | 365
Peripheral demyelinating neuropathy 2 | 7
Photosensitivity of skin 2 | 51
Poikiloderma 2 | 14
Polycystic ovary syndrome 2 | 360
Precociously senile appearance 2 | 18
Progressive mental retardation 2 | 37
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Reduced tensile strength of hair 2 | 25
Retinal Diseases 2 | 55
Sensorineural Hearing Loss (disorder) 2 | 284
Squamous cell carcinoma of skin 2 | 11
Strabismus 2 | 270
Telangiectasia of the skin 2 | 39
Thin skin 2 | 47
Tooth Abnormalities 2 | 69
Waldenstrons macroglobulinemia 2 | 765
Xeroderma pigmentosum group F 2 | 22
Xerosis 2 | 75
acute quadriplegic myopathy 2 | 1,158
hearing impairment 2 | 199
hypopigmented skin patch 2 | 59
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678

Target Family

Enzyme 18 | 4,145
Non-IDG 14 | 12,091
Kinase 1 | 634

GO Process

7-methylguanosine mRNA capping 33 | 33
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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