Development Level

Tbio 508 | 11,445
Tdark 145 | 6,588
Tchem 131 | 1,598
Tclin 44 | 613

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 19 | 499
decreased body weight 18 | 161
decreased total body fat amoun... 18 | 207
abnormal behavior 14 | 298
increased startle reflex 14 | 112
embryonic lethality prior to t... 13 | 278
enlarged heart 11 | 210
increased lean body mass 11 | 172
abnormal embryo size 10 | 220
abnormal heart morphology 10 | 162
abnormal bone structure 9 | 187
decreased bone mineral density 8 | 126
decreased vertical activity 8 | 208
decreased blood urea nitrogen ... 7 | 51
decreased circulating serum al... 7 | 82
decreased lean body mass 7 | 135
hypoactivity 7 | 132
increased bone mineral density 7 | 72
increased total body fat amoun... 7 | 134
male infertility 7 | 123
abnormal seminal vesicle morph... 6 | 114
decreased circulating choleste... 6 | 93
decreased circulating triglyce... 6 | 79
embryonic growth retardation 6 | 106
increased mean corpuscular hem... 6 | 96
short tibia 6 | 97
abnormal bone mineralization 5 | 38
abnormal eye morphology 5 | 68
abnormal gait 5 | 69
abnormal kidney morphology 5 | 65
decreased body length 5 | 101
decreased circulating aspartat... 5 | 34
decreased circulating glucose ... 5 | 126
decreased grip strength 5 | 116
decreased heart left ventricle... 5 | 28
decreased neutrophil cell numb... 5 | 42
embryonic lethality prior to o... 5 | 239
female infertility 5 | 60
hyperactivity 5 | 148
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
abnormal neural tube closure 4 | 46
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased circulating triglyce... 4 | 42
increased mean corpuscular vol... 4 | 92
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal forebrain development 3 | 20
abnormal hindbrain development 3 | 16
abnormal midbrain development 3 | 20
abnormal retina morphology 3 | 71
abnormal retinal vasculature m... 3 | 27
abnormal vertebrae morphology 3 | 18
decreased circulating alanine ... 3 | 47
decreased circulating chloride... 3 | 30
decreased circulating free fat... 3 | 31
decreased circulating iron lev... 3 | 32
decreased circulating phosphat... 3 | 27
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating aspartat... 3 | 15
increased circulating creatini... 3 | 38
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 36
increased mean platelet volume 3 | 45
increased or absent threshold ... 3 | 101
prenatal lethality prior to he... 3 | 87
thin ventricular wall 3 | 24
vertebral transformation 3 | 12
abnormal cornea morphology 2 | 31
abnormal heart left ventricle ... 2 | 16
abnormal liver morphology 2 | 17
abnormal skin coloration 2 | 25
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
increased cardiac muscle contr... 2 | 8
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26

Disease

Carcinoma 559 | 11,493
ovarian cancer 410 | 8,520
osteosarcoma 399 | 7,950
psoriasis 310 | 6,694
medulloblastoma, large-cell 292 | 6,241
glioblastoma 279 | 5,792
lung cancer 248 | 4,740
atypical teratoid / rhabdoid tumor 244 | 5,112
group 3 medulloblastoma 190 | 4,104
ependymoma 180 | 4,679
malignant mesothelioma 180 | 3,232
adult high grade glioma 178 | 3,801
Breast cancer 169 | 3,578
Cancer 168 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 165 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 157 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 154 | 2,989
Kidney cancer 152 | 2,613
primitive neuroectodermal tumor 150 | 3,035
invasive ductal carcinoma 142 | 2,951
non-small cell lung cancer 131 | 2,890
oligodendroglioma 125 | 2,850
lung adenocarcinoma 124 | 2,716
Astrocytoma, Pilocytic 120 | 3,081
lung carcinoma 116 | 2,843
pancreatic cancer 116 | 2,398
astrocytic glioma 110 | 2,597
subependymal giant cell astrocytoma 107 | 2,287
group 4 medulloblastoma 106 | 1,855
ulcerative colitis 102 | 1,819
interstitial cystitis 97 | 2,312
cystic fibrosis 90 | 1,696
pituitary cancer 89 | 1,972
tuberculosis 89 | 2,010
breast carcinoma 86 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,962
ductal carcinoma in situ 82 | 1,745
Pick disease 80 | 1,894
diabetes mellitus 80 | 1,728
colon cancer 79 | 1,478
adrenocortical carcinoma 74 | 1,428
astrocytoma 73 | 1,146
Autosomal recessive predisposition 67 | 1,442
Rheumatoid arthritis 67 | 1,191
juvenile dermatomyositis 67 | 1,187
Intellectual disability 62 | 1,016
Schizophrenia 62 | 1,160
primary pancreatic ductal adenocarcinoma 58 | 1,109
Multiple myeloma 56 | 1,332
active Crohn's disease 56 | 922
acute quadriplegic myopathy 56 | 1,158
cutaneous lupus erythematosus 53 | 1,057
Atopic dermatitis 50 | 952
dermatomyositis 49 | 966
Endometriosis 47 | 540
acute myeloid leukemia 46 | 783
gastric carcinoma 46 | 807
spina bifida 45 | 1,074
Bipolar Disorder 44 | 666
active ulcerative colitis 44 | 764
Obesity 42 | 678
Melanoma 41 | 711
esophageal adenocarcinoma 41 | 737
Epilepsy 40 | 792
Breast Neoplasms 39 | 445
medulloblastoma 39 | 720
nasopharyngeal carcinoma 39 | 1,058
Dull intelligence 38 | 645
Low intelligence 38 | 645
Mammary Neoplasms 38 | 425
Mental Retardation 38 | 645
Mental deficiency 38 | 645
Poor school performance 38 | 645
non primary Sjogren syndrome sicca 38 | 891
pediatric high grade glioma 38 | 1,064
Short stature 37 | 531
Liver Cirrhosis, Experimental 35 | 769
Waldenstrons macroglobulinemia 35 | 765
Alzheimer's disease 32 | 658
Muscle hypotonia 32 | 571
primary Sjogren syndrome 32 | 735
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
Prostatic Neoplasms 31 | 495
tuberculosis and treatment for 6 months 30 | 409
Liver cancer 29 | 604
Multiple Sclerosis 29 | 540
Seizures 29 | 596
hepatocellular carcinoma 29 | 547
progressive supranuclear palsy 29 | 676
Acquired metabolic disease 28 | 336
Amyotrophic lateral sclerosis 28 | 451
Hypertension 28 | 396
Neurodegenerative disease 28 | 414
atypical teratoid/rhabdoid tumor 28 | 357
mucosa-associated lymphoid tissue lymphoma 28 | 484
Down syndrome 27 | 499
Skin cancer 27 | 469
posterior fossa group A ependymoma 27 | 468

Tissue

Endocrine System 787 | 18,159
Female tissues 775 | 17,400
Digestive Tract 771 | 17,369
Skin and soft tissues 758 | 17,230
Male tissues 756 | 17,142
Blood and immune system 751 | 16,909
Urinary Tract 749 | 16,678
Liver and Pancreas 747 | 16,750
Nervous System 746 | 16,725
Respiratory system 739 | 16,393
Cardiovascular System 701 | 15,192

Target Family

Non-IDG 321 | 12,091
Enzyme 307 | 4,145
Transcription Factor 82 | 1,400
Nuclear Receptor 46 | 48
Epigenetic 45 | 242
TF/Epigenetic 11 | 38
Kinase 7 | 634
Ion Channel 6 | 344
Transporter 3 | 473

GO Function

zinc ion binding 828 | 828
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187
Methyl-CpG-binding domain protein 1 MBD1 Tbio Transcription Factor -2.23809 171.1 297
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Zinc finger SWIM domain-containing protein 6 ZSWIM6 Tbio Non-IDG -1.22042 16.2 67
Mitochondrial import inner membrane translocase subunit Tim13 TIMM13 Tbio Enzyme -1.90930 75.7 32
Mitochondrial import inner membrane translocase subunit Tim9 TIMM9 Tbio Enzyme -1.31703 21.3 72
MBT domain-containing protein 1 MBTD1 Tdark Epigenetic -0.59314 4.06 83