Development Level

Tbio 692 | 10,625
Tdark 258 | 7,003
Tchem 161 | 1,890
Tclin 44 | 602

IMPC Term

preweaning lethality, complete... 43 | 633
decreased body weight 25 | 174
preweaning lethality, incomple... 23 | 260
decreased total body fat amoun... 20 | 186
abnormal behavior 18 | 226
decreased lean body mass 13 | 195
short tibia 13 | 82
hyperactivity 12 | 108
abnormal retina morphology 11 | 100
decreased body length 10 | 108
abnormal bone structure 9 | 131
decreased bone mineral density 9 | 126
embryonic lethality prior to t... 9 | 187
hypoactivity 9 | 89
abnormal bone mineralization 8 | 55
decreased grip strength 8 | 123
increased bone mineral content 8 | 92
increased circulating choleste... 8 | 53
increased lean body mass 8 | 107
abnormal embryo size 7 | 112
decreased bone mineral content 7 | 157
decreased circulating choleste... 7 | 85
decreased circulating serum al... 7 | 79
decreased heart weight 7 | 44
abnormal eye morphology 6 | 38
abnormal gait 6 | 51
abnormal retinal pigmentation 6 | 61
decreased circulating glucose ... 6 | 121
enlarged heart 6 | 111
increased circulating triglyce... 6 | 24
increased or absent threshold ... 6 | 128
decreased caudal vertebrae num... 5 | 49
decreased circulating HDL chol... 5 | 77
decreased circulating alanine ... 5 | 53
decreased circulating alkaline... 5 | 41
decreased hemoglobin content 5 | 53
increased circulating HDL chol... 5 | 63
increased circulating alkaline... 5 | 119
increased circulating creatini... 5 | 29
increased sacral vertebrae num... 5 | 62
prenatal lethality prior to he... 5 | 64
abnormal behavioral response t... 4 | 52
abnormal heart left ventricle ... 4 | 20
abnormal neural tube closure 4 | 37
abnormal sleep behavior 4 | 63
decreased CD4-positive, CD25-p... 4 | 24
decreased circulating aspartat... 4 | 27
decreased circulating chloride... 4 | 32
decreased circulating free fat... 4 | 39
decreased circulating total pr... 4 | 41
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
improved glucose tolerance 4 | 56
increased body weight 4 | 42
increased exploration in new e... 4 | 56
increased mean corpuscular hem... 4 | 93
increased monocyte cell number 4 | 27
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal kidney morphology 3 | 30
abnormal lens morphology 3 | 73
abnormal locomotor activation 3 | 26
abnormal midbrain development 3 | 22
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
abnormal vocalization 3 | 21
decreased Ly6C low monocyte nu... 3 | 23
decreased blood urea nitrogen ... 3 | 31
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating fructosa... 3 | 31
decreased circulating triglyce... 3 | 83
decreased eosinophil cell numb... 3 | 41
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased neutrophil cell numb... 3 | 37
decreased rib number 3 | 59
decreased total retina thickne... 3 | 20
decreased vertical activity 3 | 22
dilated heart left ventricle 3 | 10
female infertility 3 | 34
hydrops fetalis 3 | 22
impaired glucose tolerance 3 | 52
increased B cell number 3 | 23
increased NK cell number 3 | 19
increased circulating calcium ... 3 | 32
increased circulating magnesiu... 3 | 10
increased effector memory CD4-... 3 | 15
increased fasted circulating g... 3 | 68
increased heart rate 3 | 17
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 21
increased startle reflex 3 | 38
limb grasping 3 | 35
male infertility 3 | 62
shortened RR interval 3 | 19
straub tail 3 | 26
thrombocytopenia 3 | 46

Disease

ovarian cancer 589 | 8,484
osteosarcoma 570 | 7,933
medulloblastoma, large-cell 419 | 6,234
psoriasis 419 | 6,685
glioblastoma 373 | 5,572
lung cancer 302 | 4,466
atypical teratoid / rhabdoid tumor 296 | 4,369
malignant mesothelioma 233 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 232 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 219 | 2,956
primitive neuroectodermal tumor 219 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 211 | 2,988
Breast cancer 192 | 3,094
Cancer 188 | 2,346
invasive ductal carcinoma 181 | 2,950
oligodendroglioma 180 | 2,849
pilocytic astrocytoma 173 | 3,086
Carcinoma 169 | 2,147
group 4 medulloblastoma 169 | 1,875
pediatric high grade glioma 165 | 2,712
lung adenocarcinoma 161 | 2,713
non-small cell lung cancer 160 | 2,798
ependymoma 157 | 2,514
lung carcinoma 156 | 2,844
subependymal giant cell astrocytoma 156 | 2,287
pancreatic cancer 154 | 2,300
adult high grade glioma 144 | 2,148
astrocytic glioma 141 | 2,241
group 3 medulloblastoma 141 | 2,254
ulcerative colitis 137 | 2,087
Pick disease 122 | 1,893
interstitial cystitis 121 | 2,299
astrocytoma 116 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,795
cystic fibrosis 107 | 1,665
breast carcinoma 106 | 1,614
pituitary cancer 105 | 1,972
adrenocortical carcinoma 104 | 1,427
ductal carcinoma in situ 103 | 1,745
juvenile dermatomyositis 103 | 1,189
sonic hedgehog group medulloblastoma 102 | 1,482
medulloblastoma 96 | 1,524
tuberculosis 96 | 1,557
posterior fossa group A ependymoma 95 | 1,511
primary pancreatic ductal adenocarcinoma 94 | 1,271
colon cancer 91 | 1,475
Rheumatoid Arthritis 90 | 1,160
diabetes mellitus 90 | 1,663
acute quadriplegic myopathy 85 | 1,157
spina bifida 84 | 1,064
atypical teratoid/rhabdoid tumor 82 | 1,095
Multiple myeloma 79 | 1,327
dermatomyositis 74 | 933
active Crohn's disease 72 | 918
posterior fossa group B ependymoma 68 | 1,530
acute myeloid leukemia 64 | 780
cutaneous lupus erythematosus 64 | 1,056
gastric carcinoma 62 | 832
Atopic dermatitis 59 | 944
Intellectual disability 55 | 573
tuberculosis and treatment for 6 months 55 | 686
esophageal adenocarcinoma 52 | 737
primary Sjogren syndrome 52 | 789
nasopharyngeal carcinoma 51 | 1,056
non primary Sjogren syndrome sicca 49 | 840
Waldenstrons macroglobulinemia 48 | 765
progressive supranuclear palsy 48 | 674
Endometriosis 46 | 535
Amyotrophic Lateral Sclerosis 43 | 431
Mammary Neoplasms 43 | 410
Obesity 40 | 616
active ulcerative colitis 39 | 477
Alzheimer's disease 38 | 644
Down syndrome 37 | 548
hepatocellular carcinoma 37 | 532
aldosterone-producing adenoma 35 | 664
Schizophrenia 33 | 501
Prostatic Neoplasms 32 | 471
Neurodegenerative disease 31 | 383
inflammatory breast cancer 31 | 404
Acquired metabolic disease 29 | 267
chronic rhinosinusitis 29 | 512
pancreatic carcinoma 29 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 499
non-small cell lung carcinoma 28 | 413
Duchenne muscular dystrophy 27 | 602
Multiple Sclerosis 27 | 498
gastric cancer 27 | 430
glioblastoma multiforme 27 | 347
mucosa-associated lymphoid tissue lymphoma 27 | 480
facioscapulohumeral dystrophy 26 | 286
fibroadenoma 26 | 557
Stomach Neoplasms 25 | 282
Heart disease 24 | 279
interstitial lung disease 24 | 291
Bipolar Disorder 23 | 266
Melanoma 23 | 261
nephrosclerosis 23 | 329
urothelial carcinoma 23 | 318
head and neck cancer 22 | 270

Tissue

Nervous System 1,119 | 18,561
Female tissues 1,118 | 18,647
Endocrine System 1,113 | 18,512
Digestive Tract 1,112 | 18,473
Urinary Tract 1,112 | 18,444
Liver and Pancreas 1,106 | 18,136
Skin and soft tissues 1,103 | 18,115
Male tissues 1,102 | 17,969
Blood and immune system 1,101 | 17,995
Cardiovascular System 1,097 | 17,958
Respiratory system 1,080 | 17,484

Target Family

Non-IDG 444 | 11,971
Enzyme 437 | 4,146
Epigenetic 100 | 242
Transcription Factor 92 | 1,400
Nuclear Receptor 46 | 48
TF/Epigenetic 18 | 38
Kinase 9 | 634
Ion Channel 6 | 341
Transporter 3 | 473

GO Function

zinc ion binding 1,155 | 1,155
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Zinc finger CCHC domain-containing protein 16 ZCCHC16 Tdark Non-IDG -1.29964 20.8 7
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Zinc finger RNA-binding protein 2 ZFR2 Tdark Non-IDG -0.02511 0.87 5
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Cysteine-rich protein 2 CRIP2 Tbio Non-IDG -0.95386 10.4 115