Development Level

Tclin 17 | 613
Tbio 3 | 11,445
Tchem 2 | 1,598

Collection

Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal pancreas morphology 1 | 13
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
preweaning lethality, complete... 1 | 979
small heart 1 | 10
small liver 1 | 8

Disease

Carcinoma 19 | 11,493
Epilepsy 15 | 792
Kidney cancer 13 | 2,613
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
lung carcinoma 11 | 2,843
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 11 | 7,950
Atrial Fibrillation 10 | 124
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 27
adult high grade glioma 10 | 3,801
psoriasis 10 | 6,694
Astrocytoma, Pilocytic 9 | 3,081
Anesthesia for cesarean section 8 | 8
Bipolar disorder in remission 8 | 19
Major Nerve Block for Surgery 8 | 8
Regional Anesthesia for Labor Pain 8 | 9
Regional Anesthesia for Postoperative Pain 8 | 9
Regional Anesthesia for Surgery 8 | 9
Simple partial seizure 8 | 26
Tonic-clonic seizure 8 | 11
lung cancer 8 | 4,740
Administration of Local Anesthetic Nerve Block 7 | 14
Administration of Regional Anesthesia 7 | 7
Breast cancer 7 | 3,578
Local Anesthesia for Ophthalmologic Procedure 7 | 7
Local anesthesia, by infiltration 7 | 14
Local anesthetic intrathecal block 7 | 7
Postherpetic neuralgia 7 | 11
Premature ejaculation 7 | 16
Prevention of Seizures following Cranial Trauma or Surgery 7 | 7
Seizures 7 | 596
Seizures in Neurosurgery 7 | 7
Status Epilepticus 7 | 98
malignant mesothelioma 7 | 3,232
oligodendroglioma 7 | 2,850
Administration of Corneal Anesthesia 6 | 6
Hemorrhoids 6 | 13
Infestation by Phthirus pubis 6 | 7
Infestation by Sarcoptes scabiei var hominis 6 | 7
Liver cancer 6 | 604
Local Anesthesia for Endotracheal Intubation 6 | 6
Local Anesthesia for Urethral Pain 6 | 6
Neuralgia 6 | 20
Paroxysmal atrial fibrillation 6 | 14
Pediculosis capitis 6 | 7
Pruritus ani 6 | 14
Regional Anesthesia for Ophthalmologic Surgery 6 | 6
Urethritis 6 | 10
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
ovarian cancer 6 | 8,520
primitive neuroectodermal tumor 6 | 3,035
Angina Pectoris 5 | 32
Autistic Disorder 5 | 364
Brugada Syndrome (disorder) 5 | 15
Brugada syndrome 5 | 29
Cerebellar Ataxia 5 | 304
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Parkinsonism 5 | 18
Skin cancer 5 | 469
Spasticity 5 | 26
Tremor 5 | 113
astrocytic glioma 5 | 2,597
Abnormal behavior 4 | 52
Electroencephalogram abnormal 4 | 101
Infantile onset 4 | 238
Malaria 4 | 160
Neuropathy 4 | 261
Variable expressivity 4 | 157
breast carcinoma 4 | 1,638
lung adenocarcinoma 4 | 2,716
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Endocrine System 22 | 18,159
Nervous System 20 | 16,725
Digestive Tract 19 | 17,369
Female tissues 19 | 17,400
Respiratory system 19 | 16,393
Blood and immune system 18 | 16,909
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Cardiovascular System 16 | 15,192

Target Family

Ion Channel 22 | 344

GO Function

voltage-gated sodium channel a... 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Sodium channel protein type 3 subunit alpha SCN3A Tclin Ion Channel -1.98160 87.0 76
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.46568 276.3 60
Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G Tclin Ion Channel -2.16668 140.8 217
Sodium channel subunit beta-4 SCN4B Tbio Ion Channel -1.42029 24.1 85
Sodium channel protein type 8 subunit alpha SCN8A Tclin Ion Channel -2.54867 340.7 156
Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H Tclin Ion Channel -2.10494 132.8 190