Development Level

Tchem 19 | 1,890
Tbio 10 | 10,625
Tclin 9 | 602
Tdark 2 | 7,003

Collection

Eligible Ion Channel Proteins 17 | 117

IMPC Term

abnormal behavior 3 | 226
decreased fasted circulating g... 2 | 49
increased circulating chloride... 2 | 43
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal pancreas morphology 1 | 6
abnormal placenta vasculature 1 | 2
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
cyanosis 1 | 6
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased rib number 1 | 59
decreased startle reflex 1 | 48
edema 1 | 11
enlarged heart 1 | 111
hemorrhage 1 | 12
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating sodium l... 1 | 71
increased or absent threshold ... 1 | 128
male infertility 1 | 62
prenatal lethality 1 | 16
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
respiratory system phenotype 1 | 2
small heart 1 | 8
small liver 1 | 8
straub tail 1 | 26

Disease

medulloblastoma, large-cell 23 | 6,234
glioblastoma 22 | 5,572
atypical teratoid / rhabdoid tumor 19 | 4,369
osteosarcoma 18 | 7,933
ovarian cancer 17 | 8,484
pilocytic astrocytoma 16 | 3,086
Carcinoma 15 | 2,147
primitive neuroectodermal tumor 15 | 3,031
psoriasis 13 | 6,685
adult high grade glioma 12 | 2,148
oligodendroglioma 12 | 2,849
pediatric high grade glioma 12 | 2,712
lung carcinoma 9 | 2,844
Pick disease 8 | 1,893
ependymoma 8 | 2,514
medulloblastoma 8 | 1,524
posterior fossa group A ependymoma 8 | 1,511
astrocytoma 7 | 1,493
lung cancer 7 | 4,466
Bipolar Disorder 6 | 266
Epilepsy 6 | 346
astrocytic glioma 6 | 2,241
group 3 medulloblastoma 6 | 2,254
subependymal giant cell astrocytoma 6 | 2,287
Breast cancer 5 | 3,094
Malignant hyperthermia 5 | 25
Schizophrenia 5 | 501
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
invasive ductal carcinoma 5 | 2,950
lung adenocarcinoma 5 | 2,713
Amenorrhea Secondary to Ovarian Dysfunction 4 | 8
Angina pectoris 4 | 21
Aorta Dextratransposition with Intact Ventricular Septum 4 | 6
Atrophic vaginitis 4 | 14
Autistic Disorder 4 | 320
Cervical ripening procedure 4 | 9
Coarctation of aorta 4 | 6
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus 4 | 6
Congenital atresia of the pulmonary valve 4 | 6
Congenital atresia of tricuspid valve 4 | 6
Contraception 4 | 15
Corpus Luteum Insufficiency Syndrome 4 | 8
Dysfunctional uterine bleeding 4 | 9
Ebstein's anomaly of tricuspid valve 4 | 6
Endometrial Hyperplasia Prevention 4 | 9
Endometrial carcinoma 4 | 18
Endometriosis 4 | 535
Hydatidiform mole, benign 4 | 9
Hypertensive disorder 4 | 58
Impotence 4 | 45
Incomplete miscarriage 4 | 10
Induction of labor 4 | 10
Infertility Secondary to Progesterone Deficiency 4 | 8
Intellectual disability 4 | 573
Menopausal flushing 4 | 17
Postmenopausal osteoporosis 4 | 19
Pregnancy with abortive outcome 4 | 12
Prevention of Premature Labor 4 | 9
Prinzmetal angina 4 | 6
Pulmonary artery stenosis 4 | 6
Secondary malignant neoplasm of kidney 4 | 9
Secondary physiologic amenorrhea 4 | 9
Tetralogy of Fallot 4 | 35
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
malignant mesothelioma 4 | 3,162
non-small cell lung cancer 4 | 2,798
pituitary cancer 4 | 1,972
posterior fossa group B ependymoma 4 | 1,530
Ataxia 3 | 15
Atrial Fibrillation 3 | 110
Brugada Syndrome (disorder) 3 | 15
Brugada syndrome 3 | 26
Cancer 3 | 2,346
Cerebellar Ataxia 3 | 72
Cerebrovascular accident 3 | 44
Chronic Pain with Opioid Tolerance 3 | 6
Chronic pain 3 | 9
Hypertensive disease 3 | 193
Idiopathic generalized epilepsy 3 | 15
Obesity 3 | 616
Severe pain 3 | 12
Short QT syndrome 3 | 12
Subarachnoid intracranial hemorrhage 3 | 3
Timothy syndrome 3 | 12
Type 2 diabetes mellitus 3 | 189
atypical teratoid/rhabdoid tumor 3 | 1,095
group 4 medulloblastoma 3 | 1,875
primary pancreatic ductal adenocarcinoma 3 | 1,271
Alzheimer's disease 2 | 644
Hyperalgesia 2 | 71
Infertility 2 | 163
Major Depressive Disorder 2 | 106
Male infertility 2 | 170
Myopathy 2 | 128
acute quadriplegic myopathy 2 | 1,157
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
nasopharyngeal carcinoma 2 | 1,056
tuberculosis 2 | 1,557

Tissue

Digestive Tract 40 | 18,473
Endocrine System 40 | 18,512
Female tissues 40 | 18,647
Liver and Pancreas 40 | 18,136
Nervous System 40 | 18,561
Urinary Tract 40 | 18,444
Cardiovascular System 39 | 17,958
Skin and soft tissues 39 | 18,115
Blood and immune system 38 | 17,995
Male tissues 38 | 17,969
Respiratory system 37 | 17,484

Target Family

Ion Channel 34 | 341
Non-IDG 4 | 11,971
GPCR 2 | 406

GO Function

voltage-gated calcium channel ... 40 | 40
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Calcium homeostasis modulator protein 1 CALHM1 Tbio Ion Channel -1.62156 47.0 81
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tchem Ion Channel -0.48027 2.02 53
Mu-type opioid receptor OPRM1 Tclin GPCR -3.20440 1609.2 372
Two pore calcium channel protein 2 TPCN2 Tbio Ion Channel -1.55257 40.7 61
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tchem Ion Channel -1.43080 25.0 426
Cation channel sperm-associated protein 1 CATSPER1 Tchem Ion Channel -1.10671 13.0 87
Two pore calcium channel protein 1 TPCN1 Tbio Ion Channel -1.77753 59.3 38
Cation channel sperm-associated protein 3 CATSPER3 Tchem Ion Channel -1.04186 12.0 29