Development Level

Tbio 14 | 11,445
Tchem 9 | 1,598
Tclin 9 | 613
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 12 | 99

IMPC Phenotype

abnormal behavior 3 | 298
increased circulating triglyce... 3 | 42
decreased fasted circulating g... 2 | 65
impaired glucose tolerance 2 | 75
preweaning lethality, complete... 2 | 979
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cyanosis 1 | 7
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
hemorrhage 1 | 23
hyperactivity 1 | 148
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small heart 1 | 10
small liver 1 | 8
syndactyly 1 | 23

Disease

Carcinoma 32 | 11,493
medulloblastoma, large-cell 20 | 6,241
glioblastoma 19 | 5,792
adult high grade glioma 18 | 3,801
atypical teratoid / rhabdoid tumor 18 | 5,112
osteosarcoma 17 | 7,950
ovarian cancer 16 | 8,520
Astrocytoma, Pilocytic 14 | 3,081
Kidney cancer 14 | 2,613
ependymoma 14 | 4,679
group 3 medulloblastoma 13 | 4,104
primitive neuroectodermal tumor 13 | 3,035
psoriasis 12 | 6,694
Schizophrenia 10 | 1,160
oligodendroglioma 10 | 2,850
Bipolar Disorder 9 | 666
Breast cancer 9 | 3,578
lung carcinoma 8 | 2,843
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
lung cancer 6 | 4,740
subependymal giant cell astrocytoma 6 | 2,287
Endometrial cancer 5 | 311
Epilepsy 5 | 792
Liver cancer 5 | 604
Malignant hyperthermia 5 | 26
Melanoma 5 | 711
Skin cancer 5 | 469
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
Angina Pectoris 4 | 32
Hypertensive disorder 4 | 56
Intellectual disability 4 | 1,016
Prinzmetal angina 4 | 6
Type 2 diabetes mellitus 4 | 272
astrocytoma 4 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Atrial Fibrillation 3 | 124
Brugada Syndrome (disorder) 3 | 15
Brugada syndrome 3 | 29
Cancer 3 | 2,499
Cerebrovascular accident 3 | 63
Fever 3 | 138
Hypertension 3 | 396
Hypertensive disease 3 | 292
Psychotic Disorders 3 | 151
Respiratory Insufficiency 3 | 132
Subarachnoid intracranial hemorrhage 3 | 3
Timothy syndrome 3 | 11
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pediatric high grade glioma 3 | 1,064
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
Amenorrhea Secondary to Ovarian Dysfunction 2 | 8
Ataxia 2 | 15
Atrophic vaginitis 2 | 14
Autistic Disorder 2 | 364
Cardiovascular system disease 2 | 246
Cardioversion of Atrial Fibrillation 2 | 9
Constipation 2 | 181
Contraception 2 | 15
Corpus Luteum Insufficiency Syndrome 2 | 8
Depressive disorder 2 | 409
Dysfunctional uterine bleeding 2 | 9
Dystonia 2 | 164
Endometrial Hyperplasia Prevention 2 | 9
Endometrial carcinoma 2 | 15
Endometriosis 2 | 540
Hyperalgesia 2 | 83
Infertility Secondary to Progesterone Deficiency 2 | 8
Large intestine cancer 2 | 126
Major Depressive Disorder 2 | 301
Menopausal flushing 2 | 17
Mental Depression 2 | 333
Mood Disorders 2 | 184
Movement Disorders 2 | 55
Myopathy 2 | 185
Neuralgia 2 | 20
Neuropathy 2 | 261
Night Blindness 2 | 101
Night blindness, congenital stationary 2 | 16
Nonsyndromic deafness 2 | 142
Pain agnosia 2 | 104
Postherpetic neuralgia 2 | 11
Postmenopausal osteoporosis 2 | 19
Prevention of Premature Labor 2 | 9
Progressive disorder 2 | 142
Rhabdomyolysis 2 | 15
Secondary malignant neoplasm of kidney 2 | 9
Secondary physiologic amenorrhea 2 | 32
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058

Tissue

Endocrine System 36 | 18,159
Nervous System 35 | 16,725
Digestive Tract 33 | 17,369
Female tissues 31 | 17,400
Blood and immune system 30 | 16,909
Male tissues 30 | 17,142
Skin and soft tissues 30 | 17,230
Urinary Tract 28 | 16,678
Liver and Pancreas 27 | 16,750
Respiratory system 26 | 16,393
Cardiovascular System 19 | 15,192

Target Family

Ion Channel 31 | 344
Non-IDG 4 | 12,091
GPCR 1 | 408

GO Function

voltage-gated calcium channel ... 36 | 36
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tbio Ion Channel -1.46356 25.4 471
Two pore calcium channel protein 1 TPCN1 Tchem Ion Channel -1.90829 66.7 41
Interleukin-1 receptor accessory protein-like 1 IL1RAPL1 Tbio Non-IDG -1.81770 63.9 132
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.24422 170.7 75
Calcium homeostasis modulator protein 1 CALHM1 Tbio Ion Channel -1.71853 53.7 94
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tdark Ion Channel -0.50762 2.36 68
Voltage-dependent calcium channel gamma-6 subunit CACNG6 Tdark Ion Channel 0.30 0.88 101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A Tchem Ion Channel -3.06226 1140.1 64
Voltage-dependent calcium channel subunit alpha-2/delta-4 CACNA2D4 Tbio Ion Channel -1.62494 44.1 133