Development Level

Tbio 14 | 11,445
Tclin 1 | 613

IMPC Phenotype

abnormal embryo size 2 | 220
abnormal placenta size 2 | 20
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
pale yolk sac 2 | 25
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
increased monocyte cell number 1 | 63
pale liver 1 | 6
pallor 1 | 34
preweaning lethality, complete... 1 | 979
prolonged PR interval 1 | 15
small superior vagus ganglion 1 | 74

Disease

Carcinoma 12 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
group 3 medulloblastoma 6 | 4,104
psoriasis 6 | 6,694
Endometriosis 5 | 540
astrocytoma 5 | 1,146
medulloblastoma, large-cell 5 | 6,241
Kidney cancer 4 | 2,613
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
pituitary cancer 3 | 1,972
Cognitive delay 2 | 608
Endometrial cancer 2 | 311
Epidermodysplasia verruciformis 2 | 21
Epilepsy 2 | 792
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Liver cancer 2 | 604
Mental and motor retardation 2 | 608
Prostatic Neoplasms 2 | 495
Seizures 2 | 596
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
Anteriorly placed anus 1 | 7
Asymmetry of the posterior cranium 1 | 20
Birthmark 1 | 35
Breast fibroadenoma 1 | 8
Bulimia nervosa 1 | 14
Cafe-au-Lait Spots 1 | 37
Cellulitis 1 | 20
Choanal Atresia 1 | 42
Claw hand 1 | 26
Clonus 1 | 18
Connective tissue cancer 1 | 10
Convex nasal bridge 1 | 57
Cornelia de Lange syndrome 1 | 21
DOID:9917 1 | 31
Deep philtrum 1 | 21
Depressed philtrum 1 | 21
Ectopic Tissue 1 | 14
Flattening of cranial vault 1 | 20
Flattening of head 1 | 20
Full lower lip 1 | 64
Generalized hypotonia 1 | 37
High pitched voice 1 | 23
Hypernasal voice 1 | 39
Hypoplasia of scrotum 1 | 24
Joint laxity 1 | 54
Kaposi's sarcoma 1 | 22
Leiomyoma 1 | 32
Leiomyosarcoma 1 | 24
Low frustration tolerance 1 | 2
Marfanoid body habitus 1 | 11
Narrow face 1 | 54
Narrow nose 1 | 20
Narrow palate 1 | 20
Nasal voice 1 | 39
Nonorganic psychosis 1 | 84
Obsessive compulsive behavior 1 | 25
Open mouth 1 | 45
Opitz-GBBB syndrome 1 | 18
Pinched bridge of nose 1 | 14
Pinched nasal bridge 1 | 14
Plagiocephaly 1 | 20
Plagiocephaly, Nonsynostotic 1 | 20
Postnatal microcephaly 1 | 24
Primary hypomagnesemia 1 | 7
Progressive microcephaly 1 | 32
Prominent lower lip 1 | 64
Prominent nasal bridge 1 | 57
Rhomboid shaped head 1 | 20
Single transverse palmar crease 1 | 29
Skin tag 1 | 14
Sternal anomalies 1 | 19
Stricture of anus 1 | 13
Thin face 1 | 54
Thyroid Neoplasm 1 | 37
Thyroid Neoplasms 1 | 34
Underweight 1 | 17
Uterine fibroid 1 | 28
Vestibular nystagmus 1 | 6
Weight less than 3rd percentile 1 | 17
Wrinkled face 1 | 2
Xeroderma pigmentosum group G 1 | 16

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 5 | 12,091
Nuclear Receptor 1 | 48

GO Function

vitamin D receptor binding 15 | 15
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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