Development Level

Tbio 210 | 11,651
Tdark 40 | 6,593
Tchem 10 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 19 | 499
abnormal behavior 14 | 298
preweaning lethality, complete... 14 | 979
decreased bone mineral content 10 | 151
abnormal bone structure 7 | 187
decreased body length 7 | 101
decreased bone mineral density 7 | 126
male infertility 7 | 123
decreased startle reflex 6 | 75
embryonic lethality prior to t... 6 | 278
female infertility 6 | 60
increased or absent threshold ... 6 | 101
abnormal embryo size 5 | 220
decreased lean body mass 5 | 135
decreased prepulse inhibition 5 | 82
enlarged heart 5 | 210
hypoactivity 5 | 132
abnormal heart morphology 4 | 162
decreased body weight 4 | 161
decreased circulating alkaline... 4 | 46
decreased circulating glucose ... 4 | 126
decreased circulating total pr... 4 | 49
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
decreased vertical activity 4 | 208
hyperactivity 4 | 148
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
increased total body fat amoun... 4 | 134
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
anophthalmia 3 | 33
decreased blood urea nitrogen ... 3 | 51
decreased circulating fructosa... 3 | 30
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased neutrophil cell numb... 3 | 42
decreased red blood cell distr... 3 | 41
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
increased body length 3 | 32
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased heart weight 3 | 62
increased mean corpuscular hem... 3 | 96
increased red blood cell distr... 3 | 34
abnormal behavioral response t... 2 | 66
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal skin morphology 2 | 50
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
corneal opacity 2 | 32
decreased basophil cell number 2 | 16
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased heart left ventricle... 2 | 28
decreased heart rate 2 | 18
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased total retina thickne... 2 | 17
dilated heart left ventricle 2 | 11
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart left ventricle... 2 | 4
increased heart rate 2 | 23
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
limb grasping 2 | 41
long tibia 2 | 25
narrow eye opening 2 | 12
small liver 2 | 8
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
decreased circulating amylase ... 1 | 28
increased eosinophil cell numb... 1 | 11
iris synechia 1 | 3
tremors 1 | 39

Disease

Carcinoma 178 | 11,493
ovarian cancer 167 | 8,520
osteosarcoma 135 | 7,950
medulloblastoma, large-cell 109 | 6,241
glioblastoma 105 | 5,792
psoriasis 94 | 6,694
atypical teratoid / rhabdoid tumor 85 | 5,112
adult high grade glioma 67 | 3,801
ependymoma 67 | 4,679
lung cancer 67 | 4,740
group 3 medulloblastoma 64 | 4,104
Breast cancer 57 | 3,578
malignant mesothelioma 51 | 3,232
primitive neuroectodermal tumor 49 | 3,035
astrocytic glioma 48 | 2,597
Cancer 46 | 2,499
Astrocytoma, Pilocytic 44 | 3,081
subependymal giant cell astrocytoma 44 | 2,287
Kidney cancer 43 | 2,613
oligodendroglioma 42 | 2,850
Pick disease 39 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
Multiple myeloma 36 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
non-small cell lung cancer 34 | 2,890
tuberculosis 33 | 2,010
group 4 medulloblastoma 31 | 1,855
lung adenocarcinoma 31 | 2,716
spina bifida 30 | 1,074
invasive ductal carcinoma 29 | 2,951
juvenile dermatomyositis 29 | 1,187
pancreatic cancer 28 | 2,398
lung carcinoma 26 | 2,843
acute quadriplegic myopathy 25 | 1,158
Rheumatoid arthritis 24 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
ulcerative colitis 22 | 1,819
pituitary cancer 21 | 1,972
adrenocortical carcinoma 20 | 1,428
breast carcinoma 20 | 1,638
dermatomyositis 20 | 966
cystic fibrosis 18 | 1,696
interstitial cystitis 17 | 2,312
Autosomal recessive predisposition 16 | 1,442
Intellectual disability 16 | 1,016
acute myeloid leukemia 16 | 783
medulloblastoma 16 | 720
Amyotrophic lateral sclerosis 14 | 451
astrocytoma 14 | 1,146
cutaneous lupus erythematosus 14 | 1,057
diabetes mellitus 14 | 1,728
progressive supranuclear palsy 14 | 676
tuberculosis and treatment for 6 months 14 | 409
Parkinson's disease 13 | 392
active Crohn's disease 13 | 922
esophageal adenocarcinoma 13 | 737
hepatocellular carcinoma 13 | 547
Atopic dermatitis 12 | 952
Dull intelligence 12 | 645
Liver cancer 12 | 604
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Multiple Sclerosis 12 | 540
Poor school performance 12 | 645
colon cancer 12 | 1,478
ductal carcinoma in situ 12 | 1,745
non primary Sjogren syndrome sicca 12 | 891
pediatric high grade glioma 12 | 1,064
primary pancreatic ductal adenocarcinoma 12 | 1,109
gastric carcinoma 11 | 807
primary Sjogren syndrome 11 | 735
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
Waldenstrons macroglobulinemia 10 | 765
Alzheimer's disease 9 | 658
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
nasopharyngeal carcinoma 9 | 1,058
Autistic Disorder 8 | 364
Schizophrenia 8 | 1,160
Short stature 8 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
gastric cancer 8 | 459
hereditary spastic paraplegia 8 | 318
sonic hedgehog group medulloblastoma 8 | 467
Anemia 7 | 365
Endometriosis 7 | 540
Gaucher disease type 1 7 | 180
Muscle hypotonia 7 | 571
Neurodegenerative disease 7 | 414
aldosterone-producing adenoma 7 | 665
atypical teratoid/rhabdoid tumor 7 | 357
pancreatic carcinoma 7 | 562
posterior fossa group A ependymoma 7 | 468
Duchenne muscular dystrophy 6 | 601
Nystagmus 6 | 317
Obesity 6 | 678

Tissue

Endocrine System 258 | 18,159
Female tissues 255 | 17,400
Nervous System 255 | 16,725
Digestive Tract 254 | 17,369
Male tissues 254 | 17,142
Skin and soft tissues 254 | 17,230
Respiratory system 252 | 16,393
Urinary Tract 252 | 16,678
Blood and immune system 251 | 16,909
Liver and Pancreas 251 | 16,750
Cardiovascular System 247 | 15,192

Target Family

Non-IDG 131 | 12,091
Enzyme 118 | 4,145
Epigenetic 9 | 242
Transcription Factor 2 | 1,400

GO Function

ubiquitin-protein transferase ... 260 | 260
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Protein zyg-11 homolog B ZYG11B Tdark Non-IDG -0.49136 2.50 52
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
Ankyrin repeat and SOCS box protein 10 ASB10 Tbio Non-IDG -0.85286 7.76 117
E3 ubiquitin-protein ligase DZIP3 DZIP3 Tbio Enzyme -0.24304 1.68 116
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.05580 115.6 135
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.99438 10.2 174