Development Level

Tbio 200 | 10,625
Tdark 39 | 7,003
Tchem 14 | 1,890

IMPC Term

abnormal behavior 13 | 226
preweaning lethality, incomple... 12 | 260
decreased lean body mass 11 | 195
preweaning lethality, complete... 11 | 633
decreased bone mineral content 10 | 157
decreased grip strength 8 | 123
increased or absent threshold ... 8 | 128
abnormal bone structure 6 | 131
decreased bone mineral density 6 | 126
decreased heart weight 6 | 44
hypoactivity 5 | 89
abnormal embryo size 4 | 112
abnormal retina morphology 4 | 100
decreased body length 4 | 108
decreased body weight 4 | 174
decreased prepulse inhibition 4 | 52
embryonic lethality prior to t... 4 | 187
hyperactivity 4 | 108
male infertility 4 | 62
abnormal sleep behavior 3 | 63
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating fructosa... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased startle reflex 3 | 48
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
increased NK cell number 3 | 19
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased mean corpuscular vol... 3 | 91
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal retinal blood vessel ... 2 | 18
abnormal spleen morphology 2 | 36
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased CD4-positive, CD25-p... 2 | 24
decreased CD8-positive, alpha-... 2 | 26
decreased Ly6C-positive NK T c... 2 | 2
decreased NK T cell number 2 | 28
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating total pr... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased heart rate 2 | 10
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
enlarged heart 2 | 111
female infertility 2 | 34
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating triglyce... 2 | 24
increased effector memory CD8-... 2 | 14
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased monocyte cell number 2 | 27
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
narrow eye opening 2 | 15
prenatal lethality prior to he... 2 | 64
small liver 2 | 8
straub tail 2 | 26
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15
abnormal defecation 1 | 1
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular hem... 1 | 34
increased circulating creatini... 1 | 29
increased effector memory CD4-... 1 | 15
increased mean platelet volume 1 | 19
increased rib number 1 | 41
persistence of hyaloid vascula... 1 | 22
small thymus 1 | 11
thin ventricular wall 1 | 5

Disease

ovarian cancer 173 | 8,484
osteosarcoma 137 | 7,933
medulloblastoma, large-cell 110 | 6,234
glioblastoma 101 | 5,572
psoriasis 92 | 6,685
atypical teratoid / rhabdoid tumor 78 | 4,369
lung cancer 62 | 4,466
primitive neuroectodermal tumor 51 | 3,031
malignant mesothelioma 50 | 3,162
Breast cancer 49 | 3,094
subependymal giant cell astrocytoma 48 | 2,287
adult high grade glioma 45 | 2,148
pilocytic astrocytoma 45 | 3,086
astrocytic glioma 44 | 2,241
oligodendroglioma 44 | 2,849
Carcinoma 43 | 2,147
Cancer 42 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
Pick disease 39 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
ependymoma 37 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
group 4 medulloblastoma 36 | 1,875
Multiple myeloma 35 | 1,327
pediatric high grade glioma 35 | 2,712
group 3 medulloblastoma 34 | 2,254
lung adenocarcinoma 32 | 2,713
non-small cell lung cancer 32 | 2,798
spina bifida 32 | 1,064
juvenile dermatomyositis 30 | 1,189
invasive ductal carcinoma 28 | 2,950
lung carcinoma 28 | 2,844
Rheumatoid Arthritis 27 | 1,160
medulloblastoma 27 | 1,524
pancreatic cancer 26 | 2,300
ulcerative colitis 26 | 2,087
acute quadriplegic myopathy 24 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
tuberculosis and treatment for 6 months 24 | 686
pituitary cancer 22 | 1,972
sonic hedgehog group medulloblastoma 22 | 1,482
cystic fibrosis 21 | 1,665
dermatomyositis 21 | 933
adrenocortical carcinoma 20 | 1,427
astrocytoma 20 | 1,493
tuberculosis 20 | 1,557
posterior fossa group A ependymoma 19 | 1,511
interstitial cystitis 18 | 2,299
acute myeloid leukemia 16 | 780
atypical teratoid/rhabdoid tumor 16 | 1,095
breast carcinoma 16 | 1,614
esophageal adenocarcinoma 15 | 737
hepatocellular carcinoma 14 | 532
posterior fossa group B ependymoma 14 | 1,530
primary pancreatic ductal adenocarcinoma 14 | 1,271
Multiple Sclerosis 13 | 498
active Crohn's disease 13 | 918
cutaneous lupus erythematosus 13 | 1,056
diabetes mellitus 13 | 1,663
ductal carcinoma in situ 13 | 1,745
Amyotrophic Lateral Sclerosis 12 | 431
Atopic dermatitis 12 | 944
Intellectual disability 12 | 573
colon cancer 12 | 1,475
primary Sjogren syndrome 12 | 789
progressive supranuclear palsy 12 | 674
Parkinson's disease 11 | 364
non primary Sjogren syndrome sicca 11 | 840
gastric carcinoma 10 | 832
Alzheimer's disease 9 | 644
Mammary Neoplasms 9 | 410
Waldenstrons macroglobulinemia 9 | 765
Autistic Disorder 8 | 320
Neurodegenerative disease 8 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
hereditary spastic paraplegia 8 | 313
nasopharyngeal carcinoma 8 | 1,056
Endometriosis 7 | 535
Gaucher disease type 1 7 | 171
IGA Glomerulonephritis 7 | 454
gastric cancer 7 | 430
glioblastoma multiforme 7 | 347
pancreatic carcinoma 7 | 567
Duchenne muscular dystrophy 6 | 602
aldosterone-producing adenoma 6 | 664
sarcoidosis 6 | 358
Angelman syndrome 5 | 38
Down syndrome 5 | 548
Kidney disease 5 | 396
Liddle syndrome 5 | 14
Muscular atrophy 5 | 67
Renal Cell Carcinoma 5 | 199
Stomach Neoplasms 5 | 282
chronic rhinosinusitis 5 | 512
ovarian neoplasm 5 | 97
Chronic obstructive pulmonary disease 4 | 146
Male infertility 4 | 170
Prostatic Neoplasms 4 | 471
mucosa-associated lymphoid tissue lymphoma 4 | 480
non-small cell lung carcinoma 4 | 413

Tissue

Blood and immune system 251 | 17,995
Female tissues 251 | 18,647
Liver and Pancreas 251 | 18,136
Nervous System 251 | 18,561
Male tissues 250 | 17,969
Urinary Tract 250 | 18,444
Cardiovascular System 249 | 17,958
Digestive Tract 249 | 18,473
Endocrine System 249 | 18,512
Skin and soft tissues 249 | 18,115
Respiratory system 246 | 17,484

Target Family

Enzyme 128 | 4,146
Non-IDG 114 | 11,971
Epigenetic 9 | 242
Transcription Factor 2 | 1,400

GO Function

ubiquitin-protein transferase ... 253 | 253
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Protein ZNF738 ZNF738 Tdark Non-IDG 0.00000 2
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121