Development Level

Tbio 7 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
tremors 1 | 39

Disease

Carcinoma 6 | 11,493
ovarian cancer 5 | 8,520
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
atypical teratoid / rhabdoid tumor 3 | 5,112
Kidney cancer 2 | 2,613
Multiple myeloma 2 | 1,332
Pick disease 2 | 1,894
astrocytic glioma 2 | 2,597
glioblastoma 2 | 5,792
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
spina bifida 2 | 1,074
tuberculosis and treatment for 6 months 2 | 409
AUTOIMMUNE DISEASE, MULTISYSTEM, WITH FACIAL DYSMORPHISM 1 | 1
Aortic Valve Insufficiency 1 | 40
Astrocytoma, Pilocytic 1 | 3,081
Autoimmune disease, syndromic multisystem 1 | 1
Cancer 1 | 2,499
Carcinoma, Renal Cell 1 | 124
Central sleep apnea 1 | 11
Common variable immunodeficiency 1 | 101
Conventional (Clear Cell) Renal Cell Carcinoma 1 | 6
Crohn Disease 1 | 45
Crohn's disease 1 | 321
Dysgerminoma 1 | 11
Glaucoma 1 | 239
Granulomatous amebic encephalitis 1 | 8
Hereditary Clear Cell Renal Cell Carcinoma 1 | 3
Inflammatory Bowel Disease 10 1 | 1
Inflammatory Bowel Diseases 1 | 35
Inflammatory bowel disease 1 | 151
Inflammatory bowel disease 5 1 | 14
Isolated cases 1 | 72
Myopia 1 | 176
Obstructive sleep apnea 1 | 26
Ocular hypertension 1 | 42
Optic nerve disease 1 | 10
Prostate cancer 1 | 175
Renal Cell Carcinoma 1 | 214
Renal Cell Carcinoma, Nonpapillary 1 | 7
Scotoma 1 | 22
Suppression amblyopia 1 | 8
acute quadriplegic myopathy 1 | 1,158
adult high grade glioma 1 | 3,801
aldosterone-producing adenoma 1 | 665
ependymoma 1 | 4,679
esophageal adenocarcinoma 1 | 737
gastric cancer 1 | 459
hepatocellular carcinoma 1 | 547
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
juvenile dermatomyositis 1 | 1,187
medulloblastoma 1 | 720
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
primitive neuroectodermal tumor 1 | 3,035
sarcoidosis 1 | 370
subependymal giant cell astrocytoma 1 | 2,287
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 4 | 4,145
Non-IDG 3 | 12,091

GO Function

ubiquitin-like protein transfe... 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Autophagy-related protein 16-1 ATG16L1 Tbio Non-IDG -2.26343 183.4 600
Ubiquitin-like-conjugating enzyme ATG3 ATG3 Tbio Non-IDG -1.93886 74.6 466
E3 ubiquitin-protein ligase Itchy homolog ITCH Tbio Enzyme -2.06799 109.7 232
E3 ubiquitin-protein ligase RNF14 RNF14 Tbio Enzyme -1.12199 12.5 194
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
Ubiquitin-like protein 4A UBL4A Tbio Non-IDG -2.81374 660.2 112
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81