Development Level

Tbio 7 | 10,625

IMPC Term

abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
preweaning lethality, complete... 1 | 633
tremors 1 | 34

Disease

ovarian cancer 5 | 8,484
osteosarcoma 4 | 7,933
psoriasis 4 | 6,685
atypical teratoid / rhabdoid tumor 3 | 4,369
Multiple myeloma 2 | 1,327
Pick disease 2 | 1,893
astrocytic glioma 2 | 2,241
glioblastoma 2 | 5,572
malignant mesothelioma 2 | 3,162
medulloblastoma, large-cell 2 | 6,234
spina bifida 2 | 1,064
tuberculosis and treatment for 6 months 2 | 686
AUTOIMMUNE DISEASE, MULTISYSTEM, WITH FACIAL DYSMORPHISM 1 | 1
Anterior ischemic optic neuropathy 1 | 7
Aortic valve insufficiency 1 | 22
Carcinoma 1 | 2,147
Central sleep apnea 1 | 12
Conventional (Clear Cell) Renal Cell Carcinoma 1 | 7
Crohn Disease 1 | 97
Crohn's disease 1 | 304
Dysgerminoma 1 | 4
Glaucoma 1 | 134
IGA Glomerulonephritis 1 | 454
Inflammatory Bowel Disease 10 1 | 1
Inflammatory Bowel Diseases 1 | 87
Inflammatory bowel disease 1 | 142
Kidney cancer 1 | 118
Obstructive sleep apnea 1 | 28
Optic neuritis 1 | 9
Paraplegia 1 | 71
Prostate cancer 1 | 172
Refractive error 1 | 43
Renal Cell Carcinoma 1 | 199
Suppression amblyopia 1 | 6
acute quadriplegic myopathy 1 | 1,157
adult high grade glioma 1 | 2,148
aldosterone-producing adenoma 1 | 664
ependymoma 1 | 2,514
esophageal adenocarcinoma 1 | 737
gastric cancer 1 | 430
hepatocellular carcinoma 1 | 532
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
juvenile dermatomyositis 1 | 1,189
medulloblastoma 1 | 1,524
non-small cell lung cancer 1 | 2,798
oligodendroglioma 1 | 2,849
pilocytic astrocytoma 1 | 3,086
primitive neuroectodermal tumor 1 | 3,031
sarcoidosis 1 | 358
subependymal giant cell astrocytoma 1 | 2,287
ulcerative colitis 1 | 2,087

Tissue

Blood and immune system 7 | 17,995
Cardiovascular System 7 | 17,958
Digestive Tract 7 | 18,473
Endocrine System 7 | 18,512
Female tissues 7 | 18,647
Liver and Pancreas 7 | 18,136
Male tissues 7 | 17,969
Nervous System 7 | 18,561
Respiratory system 7 | 17,484
Skin and soft tissues 7 | 18,115
Urinary Tract 7 | 18,444

Target Family

Enzyme 4 | 4,146
Non-IDG 3 | 11,971

GO Function

ubiquitin-like protein transfe... 7 | 7
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.14661 162.6 72
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.08176 14.9 125
Autophagy-related protein 16-1 ATG16L1 Tbio Non-IDG -2.18554 165.8 549
Ubiquitin-like protein 4A UBL4A Tbio Non-IDG -2.79094 645.1 93
E3 ubiquitin-protein ligase Itchy homolog ITCH Tbio Enzyme -2.00526 97.0 206
E3 ubiquitin-protein ligase RNF14 RNF14 Tbio Enzyme -1.12163 12.5 176
Ubiquitin-like-conjugating enzyme ATG3 ATG3 Tbio Non-IDG -1.83095 63.0 401