Development Level

Tbio 229 | 11,445
Tchem 40 | 1,598
Tclin 16 | 613
Tdark 16 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 15 | 499
abnormal embryo size 10 | 220
decreased bone mineral content 9 | 151
abnormal behavior 8 | 298
abnormal bone structure 8 | 187
embryonic lethality prior to t... 8 | 278
embryonic lethality prior to o... 7 | 239
enlarged heart 7 | 210
increased total body fat amoun... 7 | 134
decreased bone mineral density 5 | 126
decreased leukocyte cell numbe... 5 | 73
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
hypoactivity 5 | 132
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
anophthalmia 4 | 33
decreased body length 4 | 101
decreased lean body mass 4 | 135
increased circulating HDL chol... 4 | 80
increased grip strength 4 | 41
increased mean corpuscular hem... 4 | 96
male infertility 4 | 123
short tibia 4 | 97
thrombocytopenia 4 | 56
abnormal coat- hair morphology 3 | 19
abnormal eye morphology 3 | 68
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased circulating alkaline... 3 | 46
decreased heart left ventricle... 3 | 28
decreased red blood cell distr... 3 | 41
edema 3 | 59
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased circulating serum al... 3 | 22
increased lean body mass 3 | 172
increased or absent threshold ... 3 | 101
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal digit morphology 2 | 10
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
abnormal vitreous body morphol... 2 | 10
cardiovascular system phenotyp... 2 | 36
decreased T cell number 2 | 15
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
female infertility 2 | 60
hyperactivity 2 | 148
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased mean platelet volume 2 | 45
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
limb grasping 2 | 41
prolonged QT interval 2 | 38
small adrenal glands 2 | 16
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
decreased IgG1 level 1 | 8
decreased circulating amylase ... 1 | 28
enlarged spleen 1 | 41
increased aggression 1 | 4
increased bone mineral density 1 | 72
iris synechia 1 | 3
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 200 | 11,493
ovarian cancer 186 | 8,520
osteosarcoma 163 | 7,950
medulloblastoma, large-cell 125 | 6,241
glioblastoma 120 | 5,792
psoriasis 118 | 6,694
lung cancer 115 | 4,740
atypical teratoid / rhabdoid tumor 110 | 5,112
Cancer 106 | 2,499
ependymoma 81 | 4,679
Breast cancer 73 | 3,578
adult high grade glioma 72 | 3,801
group 3 medulloblastoma 67 | 4,104
malignant mesothelioma 64 | 3,232
oligodendroglioma 64 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,291
primitive neuroectodermal tumor 57 | 3,035
subependymal giant cell astrocytoma 55 | 2,287
astrocytic glioma 54 | 2,597
Multiple myeloma 51 | 1,332
Astrocytoma, Pilocytic 49 | 3,081
non-small cell lung cancer 47 | 2,890
diabetes mellitus 46 | 1,728
Pick disease 45 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,989
pancreatic cancer 44 | 2,398
Schizophrenia 43 | 1,160
lung carcinoma 43 | 2,843
tuberculosis 43 | 2,010
Kidney cancer 42 | 2,613
lung adenocarcinoma 42 | 2,716
group 4 medulloblastoma 41 | 1,855
breast carcinoma 40 | 1,638
invasive ductal carcinoma 40 | 2,951
Autosomal recessive predisposition 38 | 1,442
Rheumatoid arthritis 38 | 1,191
astrocytoma 35 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,962
ductal carcinoma in situ 34 | 1,745
pituitary cancer 33 | 1,972
colon cancer 32 | 1,478
interstitial cystitis 31 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
adrenocortical carcinoma 29 | 1,428
ulcerative colitis 29 | 1,819
Parkinson's disease 28 | 392
acute quadriplegic myopathy 27 | 1,158
Breast Neoplasms 26 | 445
Waldenstrons macroglobulinemia 26 | 765
spina bifida 26 | 1,074
Mammary Neoplasms 25 | 425
Neurodegenerative disease 25 | 414
dermatomyositis 25 | 966
Prostatic Neoplasms 24 | 495
Intellectual disability 23 | 1,016
Bipolar Disorder 22 | 666
Depressive disorder 21 | 409
cutaneous lupus erythematosus 21 | 1,057
pediatric high grade glioma 21 | 1,064
hepatocellular carcinoma 20 | 547
Amyotrophic lateral sclerosis 19 | 451
Vascular disease 19 | 319
active Crohn's disease 19 | 922
cystic fibrosis 19 | 1,696
juvenile dermatomyositis 19 | 1,187
primary pancreatic ductal adenocarcinoma 19 | 1,109
Melanoma 18 | 711
Stomach Neoplasms 18 | 300
Autistic Disorder 17 | 364
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
acute myeloid leukemia 17 | 783
Alzheimer's disease 16 | 658
Atopic dermatitis 16 | 952
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Short stature 16 | 531
esophageal adenocarcinoma 16 | 737
Carcinoma, Hepatocellular 15 | 228
Colonic Neoplasms 15 | 142
Liver carcinoma 15 | 240
Lung Neoplasms 15 | 232
Muscle hypotonia 15 | 571
Epilepsy 14 | 792
Mental Depression 14 | 333
Seizures 14 | 596
primary Sjogren syndrome 14 | 735
Acquired scoliosis 13 | 281
Curvature of spine 13 | 282
Endometriosis 13 | 540
Hypertensive disease 13 | 292
Obesity 13 | 678
aldosterone-producing adenoma 13 | 665
gastric cancer 13 | 459
medulloblastoma 13 | 720
tuberculosis and treatment for 6 months 13 | 409

Tissue

Endocrine System 300 | 18,159
Female tissues 297 | 17,400
Digestive Tract 296 | 17,369
Male tissues 296 | 17,142
Skin and soft tissues 295 | 17,230
Urinary Tract 294 | 16,678
Blood and immune system 293 | 16,909
Nervous System 293 | 16,725
Cardiovascular System 292 | 15,192
Respiratory system 291 | 16,393
Liver and Pancreas 290 | 16,750

Target Family

Non-IDG 185 | 12,091
Enzyme 54 | 4,145
Kinase 23 | 634
Transcription Factor 21 | 1,400
GPCR 8 | 408
Epigenetic 5 | 242
Ion Channel 3 | 344
Transporter 2 | 473

GO Function

ubiquitin protein ligase bindi... 301 | 301
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Cullin-7 CUL7 Tbio Non-IDG -1.49747 38.0 139
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Ankyrin repeat and SOCS box protein 15 ASB15 Tdark Non-IDG -0.67669 6.19 6
CDK2-associated and cullin domain-containing protein 1 CACUL1 Tbio Non-IDG -0.58734 5.65 98
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.26984 173.7 468
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.46124 30.0 217