Development Level

Tbio 13 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased lactate dehydrogenas... 1 | 16

Disease

ovarian cancer 10 | 8,520
Carcinoma 7 | 11,493
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
osteosarcoma 5 | 7,950
Rheumatoid arthritis 4 | 1,191
medulloblastoma, large-cell 4 | 6,241
Alzheimer's disease 3 | 658
Kidney cancer 3 | 2,613
Pick disease 3 | 1,894
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
psoriasis 3 | 6,694
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Cancer 2 | 2,499
Dysgerminoma 2 | 11
Neurodegenerative disease 2 | 414
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010
Abnormality of metabolism/homeostasis 1 | 134
Adult onset 1 | 82
Alzheimer Disease 1 | 83
Arthritis, Juvenile 1 | 126
Ataxia, Appendicular 1 | 25
Ataxia, Truncal 1 | 21
Atrophy of cerebellum 1 | 103
Autistic Disorder 1 | 364
Bladder Neoplasm 1 | 112
Bradykinesia 1 | 34
Bronchioloalveolar Adenocarcinoma 1 | 14
Carcinoma, Renal Cell 1 | 124
Cerebellar degeneration 1 | 103
Colonic Neoplasms 1 | 142
Conventional (Clear Cell) Renal Cell Carcinoma 1 | 6
Dementia 1 | 175
Disease Progression 1 | 136
Dysarthria 1 | 192
Dystonia 1 | 164
Dystonic disease 1 | 106
Familial encephalopathy with neuroserpin inclusion bodies 1 | 10
Gait, Unsteady 1 | 29
Gaucher disease type 1 1 | 180
Giardiasis 1 | 9
Gliosis in the substantia nigra 1 | 3
Hyperreflexia 1 | 209
Infertility 1 | 188
Influenza 1 | 142
Infratentorial atrophy 1 | 103
Isolated cases 1 | 72
Klippel-Feil syndrome 1 | 15
Leprosy 1 | 73
Liver cancer 1 | 604
Lung Neoplasms 1 | 232
Malignant glioma 1 | 26
Manganese Poisoning 1 | 11
Multiple Sclerosis 1 | 540
Multiple system atrophy 1 | 29
Muscle Rigidity 1 | 49
Nerve Degeneration 1 | 121
Neuroblastoma 1 | 80
Ovarian Cysts 1 | 41
Ovarian Neoplasms 1 | 102
PARKINSON DISEASE, LATE-ONSET 1 | 20
Pain agnosia 1 | 104
Parkinson Disease 1 | 64
Parkinson's disease 1 | 392
Parkinsonian Disorders 1 | 56
Polycystic ovary syndrome 1 | 360
Postural instability 1 | 19
Progressive disorder 1 | 142
Renal Cell Carcinoma 1 | 214
Renal Cell Carcinoma, Nonpapillary 1 | 7
Spinocerebellar Ataxias 1 | 34
Toxic encephalopathy 1 | 141
Tremor 1 | 113
Type 1 diabetes mellitus 1 | 109
Urinary Bladder Neoplasms 1 | 114
Vitiligo 1 | 73
Waldenstrons macroglobulinemia 1 | 765
medulloblastoma 1 | 720
permanent atrial fibrillation 1 | 45
sarcoidosis 1 | 370
severe Alzheimer's disease 1 | 47
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 13 | 4,145

GO Function

ubiquitin protein ligase activ... 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase parkin PRKN Tbio Enzyme -2.99618 1004.1 533
E3 ubiquitin-protein ligase TRIM13 TRIM13 Tbio Enzyme -3.00079 962.9 185
E3 ubiquitin-protein ligase CHIP STUB1 Tbio Enzyme -2.96877 926.8 351
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 Tbio Enzyme -2.36966 244.7 387
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
E3 ubiquitin-protein ligase synoviolin SYVN1 Tbio Enzyme -1.52336 36.2 267
E3 ubiquitin-protein ligase RNF103 RNF103 Tbio Enzyme -1.95102 35.6 76
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166