Development Level

Tbio 132 | 10,625
Tdark 31 | 7,003
Tchem 10 | 1,890

IMPC Term

decreased lean body mass 8 | 195
preweaning lethality, incomple... 8 | 260
abnormal behavior 7 | 226
preweaning lethality, complete... 7 | 633
decreased bone mineral content 6 | 157
short tibia 5 | 82
abnormal bone structure 4 | 131
decreased bone mineral density 4 | 126
hyperactivity 4 | 108
increased fasted circulating g... 4 | 68
abnormal retina morphology 3 | 100
decreased body length 3 | 108
decreased grip strength 3 | 123
decreased heart weight 3 | 44
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
male infertility 3 | 62
abnormal coping response 2 | 12
abnormal embryo size 2 | 112
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased leukocyte cell numbe... 2 | 54
decreased rib number 2 | 59
decreased threshold for audito... 2 | 32
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
increased circulating calcium ... 2 | 32
increased heart weight 2 | 37
limb grasping 2 | 35
narrow eye opening 2 | 15
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal eye morphology 1 | 38
abnormal eyelid morphology 1 | 6
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal retinal blood vessel ... 1 | 18
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased circulating calcium ... 1 | 33
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased heart rate 1 | 10
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
hydrops fetalis 1 | 22
increased B cell number 1 | 23
increased NK cell number 1 | 19
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prolonged RR interval 1 | 2
shortened ST segment 1 | 9
straub tail 1 | 26
thrombocytopenia 1 | 46
tremors 1 | 34
trunk curl 1 | 15

Disease

ovarian cancer 107 | 8,484
osteosarcoma 88 | 7,933
medulloblastoma, large-cell 65 | 6,234
psoriasis 56 | 6,685
glioblastoma 53 | 5,572
atypical teratoid / rhabdoid tumor 44 | 4,369
lung cancer 42 | 4,466
primitive neuroectodermal tumor 33 | 3,031
Breast cancer 31 | 3,094
Cancer 30 | 2,346
adult high grade glioma 29 | 2,148
oligodendroglioma 29 | 2,849
astrocytic glioma 26 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
group 3 medulloblastoma 25 | 2,254
Carcinoma 24 | 2,147
ependymoma 24 | 2,514
group 4 medulloblastoma 24 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
malignant mesothelioma 24 | 3,162
Multiple myeloma 23 | 1,327
Pick disease 23 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
juvenile dermatomyositis 21 | 1,189
medulloblastoma 20 | 1,524
pancreatic cancer 20 | 2,300
pilocytic astrocytoma 20 | 3,086
subependymal giant cell astrocytoma 20 | 2,287
non-small cell lung cancer 18 | 2,798
acute quadriplegic myopathy 16 | 1,157
invasive ductal carcinoma 16 | 2,950
lung adenocarcinoma 16 | 2,713
pediatric high grade glioma 16 | 2,712
spina bifida 16 | 1,064
tuberculosis and treatment for 6 months 15 | 686
Rheumatoid Arthritis 13 | 1,160
lung carcinoma 13 | 2,844
ulcerative colitis 13 | 2,087
acute myeloid leukemia 12 | 780
breast carcinoma 12 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
adrenocortical carcinoma 11 | 1,427
astrocytoma 11 | 1,493
primary pancreatic ductal adenocarcinoma 11 | 1,271
sonic hedgehog group medulloblastoma 11 | 1,482
Intellectual disability 10 | 573
interstitial cystitis 10 | 2,299
pituitary cancer 10 | 1,972
tuberculosis 10 | 1,557
esophageal adenocarcinoma 9 | 737
posterior fossa group B ependymoma 9 | 1,530
dermatomyositis 8 | 933
ductal carcinoma in situ 8 | 1,745
hepatocellular carcinoma 8 | 532
primary Sjogren syndrome 8 | 789
Endometriosis 7 | 535
atypical teratoid/rhabdoid tumor 7 | 1,095
diabetes mellitus 7 | 1,663
non primary Sjogren syndrome sicca 7 | 840
active Crohn's disease 6 | 918
colon cancer 6 | 1,475
cystic fibrosis 6 | 1,665
posterior fossa group A ependymoma 6 | 1,511
Alzheimer's disease 5 | 644
Amyotrophic Lateral Sclerosis 5 | 431
Atopic dermatitis 5 | 944
Autistic Disorder 5 | 320
IGA Glomerulonephritis 5 | 454
Mammary Neoplasms 5 | 410
Parkinson's disease 5 | 364
aldosterone-producing adenoma 5 | 664
gastric cancer 5 | 430
hereditary spastic paraplegia 5 | 313
progressive supranuclear palsy 5 | 674
Anemia 4 | 252
Male infertility 4 | 170
Neurodegenerative disease 4 | 383
Waldenstrons macroglobulinemia 4 | 765
cutaneous lupus erythematosus 4 | 1,056
gastric carcinoma 4 | 832
glioblastoma multiforme 4 | 347
nasopharyngeal carcinoma 4 | 1,056
Esophageal Neoplasms 3 | 67
Familial encephalopathy with neuroserpin inclusion bodies 3 | 8
Fanconi Anemia 3 | 19
Fanconi's anemia 3 | 50
Liddle syndrome 3 | 14
Liver carcinoma 3 | 217
Malignant neoplasm of breast 3 | 63
Prostate cancer 3 | 172
Prostatic Neoplasms 3 | 471
Stevens-Johnson syndrome 3 | 78
Stomach Neoplasms 3 | 282
Von Hippel-Lindau disease 3 | 11
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
ovarian neoplasm 3 | 97
pancreatic carcinoma 3 | 567
sarcoidosis 3 | 358
tuberculosis and treatment for 3 months 3 | 327
mucosa-associated lymphoid tissue lymphoma 2 | 480

Tissue

Blood and immune system 172 | 17,995
Female tissues 172 | 18,647
Nervous System 172 | 18,561
Cardiovascular System 171 | 17,958
Digestive Tract 171 | 18,473
Endocrine System 171 | 18,512
Liver and Pancreas 171 | 18,136
Urinary Tract 171 | 18,444
Male tissues 170 | 17,969
Skin and soft tissues 169 | 18,115
Respiratory system 168 | 17,484

Target Family

Enzyme 109 | 4,146
Non-IDG 59 | 11,971
Epigenetic 4 | 242
Transcription Factor 1 | 1,400

GO Function

ubiquitin protein ligase activ... 173 | 173
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.21919 171.7 87
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
E3 ubiquitin-protein ligase TRIM71 TRIM71 Tbio Enzyme -1.30174 21.0 114
E3 ubiquitin-protein ligase ZNRF2 ZNRF2 Tdark Enzyme -0.18966 2.48 75
E3 ubiquitin-protein ligase Praja-1 PJA1 Tbio Enzyme -0.82785 7.04 108