Development Level

Tbio 22 | 11,651
Tdark 10 | 6,593
Tclin 2 | 612

IMPC Phenotype

increased circulating calcium ... 2 | 34
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hair growth 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal stomach morphology 1 | 10
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
cystolithiasis 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
limb grasping 1 | 41
polycystic kidney 1 | 15
short tibia 1 | 97
thick skin 1 | 4

Disease

osteosarcoma 23 | 7,950
ovarian cancer 23 | 8,520
Carcinoma 20 | 11,493
medulloblastoma, large-cell 17 | 6,241
glioblastoma 12 | 5,792
psoriasis 12 | 6,694
atypical teratoid / rhabdoid tumor 11 | 5,112
lung cancer 10 | 4,740
adult high grade glioma 9 | 3,801
group 3 medulloblastoma 9 | 4,104
Astrocytoma, Pilocytic 8 | 3,081
Rheumatoid arthritis 8 | 1,191
ependymoma 8 | 4,679
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
primitive neuroectodermal tumor 8 | 3,035
Breast cancer 7 | 3,578
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pancreatic cancer 6 | 2,398
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Cancer 5 | 2,499
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung carcinoma 5 | 2,843
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
Gaucher disease type 1 3 | 180
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
Parkinson's disease 3 | 392
Schizophrenia 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
tuberculosis and treatment for 6 months 3 | 409
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Autistic Disorder 2 | 364
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Coronary artery disease 2 | 268
Dull intelligence 2 | 645
Epilepsy 2 | 792
Gait abnormality 2 | 135
Huntington's disease 2 | 76
Hypoglycemia 2 | 152
Kidney cancer 2 | 2,613
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Myopathy 2 | 185
Poor school performance 2 | 645
Telecanthus 2 | 62
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
atypical teratoid/rhabdoid tumor 2 | 357
chronic rhinosinusitis 2 | 512
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
primary Sjogren syndrome 2 | 735
progressive supranuclear palsy 2 | 676
sarcoidosis 2 | 370
spina bifida 2 | 1,074
Amenorrhea 1 | 58
Autosomal recessive non-syndromic intellectual disability 1 | 7
Central sleep apnea 1 | 11
Elevated gonadotropins 1 | 15
Epicanthus inversus 1 | 3
Gastrointestinal system disease 1 | 54
Gliosis in the substantia nigra 1 | 3
Hyperglycemia 1 | 137
Hypertrichosis 1 | 46
Hypertriglyceridemia 1 | 17
Keloid 1 | 37
Keratoconjunctivitis sicca 1 | 25
Laryngostenosis 1 | 10
Multiple system atrophy 1 | 29
Muscle Rigidity 1 | 49
Opitz-GBBB syndrome 1 | 18
Ovarian dysfunction 1 | 18
PARKINSON DISEASE, LATE-ONSET 1 | 20
Postural instability 1 | 19
Premature Menopause 1 | 31
Premature ovarian failure 1 | 65
Retinitis pigmentosa 58 1 | 13
Syncope 1 | 22
blepharophimosis, ptosis, and epicanthus inversus syndrome 1 | 8

Tissue

Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Skin and soft tissues 34 | 17,230
Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Liver and Pancreas 33 | 16,750
Respiratory system 33 | 16,393
Urinary Tract 33 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 11 | 12,091
Transcription Factor 2 | 1,400
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Function

ubiquitin conjugating enzyme b... 34 | 34
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
E3 ubiquitin-protein ligase RNF114 RNF114 Tbio Enzyme -1.03564 12.8 142
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
E3 ubiquitin-protein ligase SIAH2 SIAH2 Tbio Enzyme -1.80363 66.5 173
Tripartite motif-containing protein 72 TRIM72 Tbio Non-IDG -1.98480 94.6 146
E3 ubiquitin-protein ligase RNF19B RNF19B Tbio Enzyme -0.77784 6.71 95
Toll-interacting protein TOLLIP Tbio Non-IDG -1.87544 81.6 423
E3 ubiquitin-protein ligase RNF144A RNF144A Tbio Enzyme -0.73955 4.54 155
DCN1-like protein 4 DCUN1D4 Tdark Non-IDG 0.00000 80
Peroxisome proliferator-activated receptor alpha PPARA Tclin Nuclear Receptor -3.37176 2457.9 501