Development Level

Tbio 28 | 11,651

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal pelvic girdle bone mo... 1 | 12
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hypoactivity 1 | 132
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
limb grasping 1 | 41
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small liver 1 | 8

Disease

ovarian cancer 22 | 8,520
osteosarcoma 12 | 7,950
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
psoriasis 11 | 6,694
adult high grade glioma 10 | 3,801
atypical teratoid / rhabdoid tumor 10 | 5,112
lung cancer 10 | 4,740
medulloblastoma, large-cell 10 | 6,241
Breast cancer 9 | 3,578
Multiple myeloma 9 | 1,332
group 3 medulloblastoma 9 | 4,104
astrocytic glioma 8 | 2,597
Carcinoma 6 | 11,493
Pick disease 6 | 1,894
acute quadriplegic myopathy 6 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
oligodendroglioma 6 | 2,850
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Cancer 4 | 2,499
Intellectual disability 4 | 1,016
Rheumatoid arthritis 4 | 1,191
esophageal adenocarcinoma 4 | 737
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
juvenile dermatomyositis 4 | 1,187
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
spina bifida 4 | 1,074
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive limb-girdle muscular dystrophy type 2H 3 | 7
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
lung adenocarcinoma 3 | 2,716
non primary Sjogren syndrome sicca 3 | 891
tuberculosis and treatment for 6 months 3 | 409
Almond-shaped eyes 2 | 23
Amyotrophic lateral sclerosis 2 | 451
Atopic dermatitis 2 | 952
Celiac disease 2 | 116
Down syndrome 2 | 499
Dull intelligence 2 | 645
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Familial encephalopathy with neuroserpin inclusion bodies 2 | 10
Kidney cancer 2 | 2,613
Liddle syndrome 2 | 14
Low intelligence 2 | 645
Male infertility 2 | 206
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Parkinson's disease 2 | 392
Poor school performance 2 | 645
Retinitis pigmentosa 42 2 | 9
X- linked recessive 2 | 110
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Adenoma, Liver Cell 1 | 8
Angelman syndrome 1 | 34
Ankylosing spondylitis 1 | 140
Arsenic Poisoning 1 | 62
Big calvaria 1 | 147
Breast Neoplasms 1 | 445
Cataract 7 1 | 32
Decreased platelet count 1 | 111
Dermatologic disorders 1 | 93
Dry skin 1 | 75
Dystrophia unguium 1 | 53
Enophthalmos 1 | 75
Fanconi anemia 1 | 56
Hirsutism 1 | 47
Hypoplastic feet 1 | 66
Hypotrophic malar bone 1 | 129
Kidney Neoplasms 1 | 37
Leukopenia 1 | 72
Low posterior hairline 1 | 52
Malar flattening 1 | 129
Mammary Neoplasms 1 | 425
Nail dysplasia 1 | 52
Neuronal ceroid lipofuscinosis 2 1 | 17
Skin Diseases 1 | 71
Sunken eyes 1 | 63
Synophrys 1 | 40
Syringomyelia 1 | 15
Thrombocytopenia 1 | 197
Tremor 1 | 113
Weight Gain 1 | 100
X-linked cerebral adrenoleukodystrophy 1 | 116
Xerosis 1 | 75
limb girdle muscular dystrophy 2B 1 | 40
sarcoidosis 1 | 370
triple-A syndrome 1 | 17

Tissue

Blood and immune system 28 | 16,909
Cardiovascular System 28 | 15,192
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Non-IDG 27 | 12,091
Kinase 1 | 634

GO Function

ubiquitin conjugating enzyme a... 28 | 28
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08773 125.8 222
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56328 38.9 167
Ubiquitin-conjugating enzyme E2 D3 UBE2D3 Tbio Non-IDG -1.33082 20.0 161
Ubiquitin-conjugating enzyme E2 N UBE2N Tbio Non-IDG -2.08846 107.8 268
Ubiquitin-conjugating enzyme E2 J1 UBE2J1 Tbio Non-IDG -1.12023 12.8 250
Ubiquitin-conjugating enzyme E2 D4 UBE2D4 Tbio Non-IDG -0.10266 1.25 129
Ubiquitin-conjugating enzyme E2 D2 UBE2D2 Tbio Non-IDG -2.09146 111.3 239
Ubiquitin-conjugating enzyme E2 D1 UBE2D1 Tbio Non-IDG -2.67434 446.5 194
Ubiquitin-conjugating enzyme E2 E3 UBE2E3 Tbio Non-IDG -1.19548 14.0 431
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.20770 12.4 78