Development Level

Tbio 48 | 10,625
Tchem 11 | 1,890
Tdark 5 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal behavior 2 | 226
hyperactivity 2 | 108
increased body length 2 | 20
increased circulating alkaline... 2 | 119
increased monocyte cell number 2 | 27
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal hair texture 1 | 4
abnormal heart position or ori... 1 | 1
abnormal incisor morphology 1 | 3
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal spine curvature 1 | 7
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased effector memory CD4-... 1 | 6
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased heart weight 1 | 37
male infertility 1 | 62
shortened RR interval 1 | 19

Disease

ovarian cancer 51 | 8,484
osteosarcoma 39 | 7,933
glioblastoma 26 | 5,572
lung cancer 25 | 4,466
medulloblastoma, large-cell 25 | 6,234
psoriasis 24 | 6,685
atypical teratoid / rhabdoid tumor 17 | 4,369
Cancer 16 | 2,346
Multiple myeloma 14 | 1,327
non-small cell lung cancer 13 | 2,798
Pick disease 12 | 1,893
dermatomyositis 12 | 933
oligodendroglioma 12 | 2,849
subependymal giant cell astrocytoma 12 | 2,287
invasive ductal carcinoma 11 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
posterior fossa group A ependymoma 11 | 1,511
primitive neuroectodermal tumor 11 | 3,031
Breast cancer 10 | 3,094
diabetes mellitus 10 | 1,663
group 3 medulloblastoma 10 | 2,254
malignant mesothelioma 10 | 3,162
pilocytic astrocytoma 10 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
pediatric high grade glioma 9 | 2,712
tuberculosis 9 | 1,557
Waldenstrons macroglobulinemia 8 | 765
adult high grade glioma 8 | 2,148
astrocytic glioma 8 | 2,241
astrocytoma 8 | 1,493
lung adenocarcinoma 8 | 2,713
Atopic dermatitis 7 | 944
Rheumatoid Arthritis 7 | 1,160
adrenocortical carcinoma 7 | 1,427
cystic fibrosis 7 | 1,665
esophageal adenocarcinoma 7 | 737
group 4 medulloblastoma 7 | 1,875
interstitial cystitis 7 | 2,299
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
ulcerative colitis 7 | 2,087
acute myeloid leukemia 6 | 780
colon cancer 6 | 1,475
ependymoma 6 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
juvenile dermatomyositis 6 | 1,189
lung carcinoma 6 | 2,844
pituitary cancer 6 | 1,972
Carcinoma 5 | 2,147
Crohn's disease 5 | 304
Neurodegenerative disease 5 | 383
cutaneous lupus erythematosus 5 | 1,056
ductal carcinoma in situ 5 | 1,745
medulloblastoma 5 | 1,524
pancreatic cancer 5 | 2,300
Alzheimer's disease 4 | 644
Endometriosis 4 | 535
active Crohn's disease 4 | 918
breast carcinoma 4 | 1,614
Bipolar Disorder 3 | 266
Dementia 3 | 129
Down syndrome 3 | 548
IGA Glomerulonephritis 3 | 454
Liver carcinoma 3 | 217
Multiple Sclerosis 3 | 498
Myeloid Leukemia, Chronic 3 | 22
Myocardial Infarction 3 | 126
Parkinson's disease 3 | 364
Prostatic Neoplasms 3 | 471
Type 2 diabetes mellitus 3 | 189
atypical teratoid/rhabdoid tumor 3 | 1,095
chronic rhinosinusitis 3 | 512
gastric carcinoma 3 | 832
nasopharyngeal carcinoma 3 | 1,056
primary Sjogren syndrome 3 | 789
progressive supranuclear palsy 3 | 674
Acquired metabolic disease 2 | 267
Asthma 2 | 349
Autistic Disorder 2 | 320
Colonic Neoplasms 2 | 126
Disease Progression 2 | 125
Frontotemporal dementia 2 | 41
Inflammatory Bowel Diseases 2 | 87
Intellectual disability 2 | 573
Juvenile arthritis 2 | 124
Lymphoma, Follicular 2 | 20
Neoplasm Metastasis 2 | 138
Neuropathy 2 | 210
Obesity 2 | 616
Paget's disease of bone 2 | 28
Polycystic Ovary Syndrome 2 | 332
Stomach Neoplasms 2 | 282
Vascular disease 2 | 281
acute quadriplegic myopathy 2 | 1,157
aldosterone-producing adenoma 2 | 664
inflammatory breast cancer 2 | 404
non-small cell lung carcinoma 2 | 413
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 358

Tissue

Blood and immune system 66 | 17,995
Cardiovascular System 66 | 17,958
Digestive Tract 66 | 18,473
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Nervous System 66 | 18,561
Respiratory system 66 | 17,484
Skin and soft tissues 66 | 18,115
Urinary Tract 66 | 18,444

Target Family

Non-IDG 39 | 11,971
Enzyme 20 | 4,146
Transcription Factor 3 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242
GPCR 1 | 406

GO Function

ubiquitin binding 66 | 66
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Ubiquitin-associated protein 1 UBAP1 Tbio Non-IDG -2.19455 155.9 107
Period circadian protein homolog 2 PER2 Tchem Non-IDG -2.62596 424.2 213
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.81595 662.3 551
Rhomboid domain-containing protein 2 RHBDD2 Tbio Enzyme -0.62411 5.30 32
SprT-like domain-containing protein Spartan SPRTN Tbio Non-IDG -2.15267 150.6 58
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.46566 28.7 150
Cryptochrome-2 CRY2 Tbio Non-IDG -2.33124 215.9 131
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.03840 1043.2 1391