Development Level

Tbio 46 | 11,445
Tchem 10 | 1,598
Tdark 6 | 6,588
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 2 | 220
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
impaired glucose tolerance 2 | 75
increased body length 2 | 32
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal heart position or ori... 1 | 1
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal spine curvature 1 | 9
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17
thrombocytosis 1 | 27

Disease

ovarian cancer 48 | 8,520
osteosarcoma 38 | 7,950
Carcinoma 37 | 11,493
glioblastoma 22 | 5,792
lung cancer 21 | 4,740
psoriasis 21 | 6,694
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
Cancer 18 | 2,499
Multiple myeloma 17 | 1,332
group 3 medulloblastoma 16 | 4,104
ependymoma 14 | 4,679
oligodendroglioma 13 | 2,850
subependymal giant cell astrocytoma 13 | 2,287
adult high grade glioma 12 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
tuberculosis 12 | 2,010
Astrocytoma, Pilocytic 11 | 3,081
Breast cancer 11 | 3,578
dermatomyositis 11 | 966
diabetes mellitus 10 | 1,728
non-small cell lung cancer 10 | 2,890
primitive neuroectodermal tumor 10 | 3,035
Pick disease 9 | 1,894
astrocytoma 9 | 1,146
group 4 medulloblastoma 9 | 1,855
interstitial cystitis 9 | 2,312
astrocytic glioma 8 | 2,597
invasive ductal carcinoma 8 | 2,951
juvenile dermatomyositis 8 | 1,187
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
Neurodegenerative disease 7 | 414
Waldenstrons macroglobulinemia 7 | 765
esophageal adenocarcinoma 7 | 737
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic cancer 7 | 2,398
spina bifida 7 | 1,074
Autosomal recessive predisposition 6 | 1,442
Kidney cancer 6 | 2,613
Rheumatoid arthritis 6 | 1,191
acute myeloid leukemia 6 | 783
adrenocortical carcinoma 6 | 1,428
lung carcinoma 6 | 2,843
pediatric high grade glioma 6 | 1,064
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Atopic dermatitis 5 | 952
Intellectual disability 5 | 1,016
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
Breast Neoplasms 4 | 445
Crohn's disease 4 | 321
Dull intelligence 4 | 645
Hyperreflexia 4 | 209
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
ductal carcinoma in situ 4 | 1,745
Carcinoma, Hepatocellular 3 | 228
Decreased tendon reflex 3 | 122
Dystonia 3 | 164
Dystonic disease 3 | 106
Endometriosis 3 | 540
Liver carcinoma 3 | 240
Mammary Neoplasms 3 | 425
Multiple Sclerosis 3 | 540
Nerve Degeneration 3 | 121
Progressive disorder 3 | 142
Short stature 3 | 531
Slow progression 3 | 89
Stomach Neoplasms 3 | 300
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
cutaneous lupus erythematosus 3 | 1,057
hereditary spastic paraplegia 3 | 318
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
primary Sjogren syndrome 3 | 735
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Colonic Neoplasms 2 | 142
Creatine phosphokinase serum increased 2 | 110
Dementia 2 | 175
Disease Progression 2 | 136
Elevated creatine kinase 2 | 110
Failure to gain weight 2 | 365
Huntington's disease 2 | 76
Inflammatory bowel disease 2 | 151
Leukemia 2 | 104
Pediatric failure to thrive 2 | 365
Physical aggression 2 | 76
Polycystic ovary syndrome 2 | 360
active Crohn's disease 2 | 922

Tissue

Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Cardiovascular System 64 | 15,192

Target Family

Non-IDG 41 | 12,091
Enzyme 18 | 4,145
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
GPCR 1 | 408
Kinase 1 | 634

GO Function

ubiquitin binding 65 | 65
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
FAS-associated factor 1 FAF1 Tbio Non-IDG -1.71858 56.5 209
UBX domain-containing protein 7 UBXN7 Tbio Non-IDG -1.23045 16.3 23
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.53597 32.3 117
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Tumor protein p53-inducible nuclear protein 2 TP53INP2 Tbio Non-IDG -1.65451 44.3 113
Ubiquitin carboxyl-terminal hydrolase 5 USP5 Tchem Enzyme -2.22247 166.1 227
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.88264 723.0 847
Ubiquitin carboxyl-terminal hydrolase isozyme L1 UCHL1 Tchem Enzyme -3.16318 1414.2 1378
Ubiquitin thioesterase OTUB2 OTUB2 Tbio Enzyme -1.01946 11.0 252