Development Level

Tbio 2 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal testis morphology 1 | 43
decreased eosinophil cell numb... 1 | 24
edema 1 | 59
enlarged lymph nodes 1 | 37
preweaning lethality, complete... 1 | 979

Disease

Aortic Valve Insufficiency 4 | 40
Cancer 4 | 2,499
Cleft Palate 4 | 271
Coronary artery disease 4 | 268
Hypertensive disease 4 | 292
Abnormality of the iris 3 | 14
Acquired flat foot 3 | 72
Acquired scoliosis 3 | 281
Aortic aneurysm, familial thoracic 3 3 | 13
Arachnodactyly 3 | 49
Ascending aortic dissection 3 | 13
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Byzanthine arch palate 3 | 194
Carcinoma 3 | 11,493
Cardiomegaly 3 | 116
Chest Pain 3 | 38
Curvature of spine 3 | 282
Cutis marmorata 3 | 32
Cystic medial necrosis of aorta 3 | 13
Descending aortic dissection 3 | 13
Dyspnea on exertion 3 | 24
Dyspnea, Paroxysmal 3 | 13
Exophthalmos 3 | 112
Familial thoracic aortic aneurysm and aortic dissection 3 | 13
Flatfoot 3 | 73
Hernia, Inguinal 3 | 89
Impaired left ventricular function 3 | 16
Increase in blood pressure 3 | 119
Left-Sided Heart Failure 3 | 16
Liver Cirrhosis, Experimental 3 | 769
Loeys-Dietz Aortic Aneurysm Syndrome 3 | 13
Loeys-Dietz syndrome 3 | 23
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Retrognathia 3 | 54
Tall stature 3 | 34
cystic fibrosis 3 | 1,696
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
Aortic Aneurysm, Thoracic 2 | 8
Aortic aneurysm 2 | 38
Arterial tortuosity 2 | 5
Blue sclera 2 | 32
Cleft uvula 2 | 27
Congenital abnormality of respiratory system 2 | 3
Connective tissue disease 2 | 62
Craniofacial Abnormalities 2 | 151
Craniosynostosis 2 | 74
Dental caries 2 | 164
Depressive disorder 2 | 409
Diabetic Nephropathies 2 | 37
Diabetic Nephropathy 2 | 34
Dissection of aorta 2 | 9
Exotropia 2 | 35
Eye Abnormalities 2 | 35
Loeys-Dietz syndrome 4 2 | 4
Lung Neoplasms 2 | 232
Malabsorption 2 | 82
Neoplasm Metastasis 2 | 168
Orbital separation excessive 2 | 244
Prostatic Neoplasms 2 | 495
Pulmonary Fibrosis 2 | 106
Respiratory System Abnormalities 2 | 3
Schizophrenia 2 | 1,160
Squamous cell carcinoma 2 | 129
Sternal anomalies 2 | 19
Thoracic aortic aneurysm 2 | 15
Ureteral obstruction 2 | 33
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 4,104
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
pancreatic cancer 2 | 2,398
Berylliosis 1 | 28
Biliary cirrhosis 1 | 45
Brain Neoplasms 1 | 33
Cardiomyopathy, right ventricular 1 | 7
Cholangitis 1 | 32
Congenital musculoskeletal anomalies 1 | 5
Congenital pectus carinatum 1 | 52
Decreased muscle mass 1 | 28
Diabetic Neuropathies 1 | 14
Diaphragmatic Hernia 1 | 40
Hepatitis, Chronic 1 | 23
Hernia, Diaphragmatic 1 | 40
Hyperostosis 1 | 18
Musculoskeletal Abnormalities 1 | 6
Oral Submucous Fibrosis 1 | 20
Pancreatic Insufficiency 1 | 13
Peyronie's disease 1 | 9
Radial aplasia/hypoplasia 1 | 29

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Non-IDG 3 | 12,091
Kinase 1 | 634

GO Function

type III transforming growth f... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Transforming growth factor beta-2 TGFB2 Tbio Non-IDG -3.14427 1378.3 384
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548